DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Klp98A

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	990	Identity:	274/990 - (27%)
Similarity:	422/990 - (42%)	Gaps:	290/990 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGV----VELQNVVDGNKEQRKVFTYDAAY---DAS- 76
            ::|.||.||.::|| .:...:::....|:..    ..||::.|..::....||:|.:|   ||.
  Fly     4 LKVAVRVRPFNSRE-IDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67

  Fly    77 ---ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIW- 137
               |||..:|.::...:|....||:|.|:|||||||:||||||.|...|.   |:|||..|:::
  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNP---GLIPRICEELFA 129

  Fly   138 -LHINRTENFQFLVDVSYLEIYMEELRDLLKPNSK-H-LEVRE-RGSGVYVPNL--HAINCKSVE 196
             :.:.:.....:....||||||.|.::|||...|. | |.||| |..|.||.||  ||::  ..:
  Fly   130 RMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVS--DFD 192

  Fly   197 DMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMI----KIEMCDTETNTIKVGKLNLIDLAGSERQ 257
            ::.:.:..||..||...||||:.||||||||.|    .:.|.|..:.|  |.|::|:|||||||.
  Fly   193 EIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSET--VSKIHLVDLAGSERA 255

  Fly   258 SKTGASAERLKEASKINLALSSLGNVISALAE--------------SSP--------HVPYRDSK 300
            :.|||:.:||||.:.||.:|.:||:|||||||              ::|        ::|||||.
  Fly   256 NATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSI 320

  Fly   301 LTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEE 365
            ||.||:|||||||||||||.:.|::.||:|||:|||||:|||:|.|:|..|||.....::|.:||
  Fly   321 LTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREE 385

  Fly   366 IERLKRLI-GPQQQQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQV--STIEQP----------- 416
            |.:||.:: |.....:...:|.|..|: |:.:::.:|:|.::..:|  |.:::.
  Fly   386 INKLKSMLAGDIHSLQPSLKVLADLQK-KEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVG 449

  Fly   417 -VEDDSDP---------------------------EGAESESDKE-------------------- 433
             |.|...|                           |.|:...|.|
  Fly   450 VVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVV 514

  Fly   434 ----------------------------------------NEAEVAKSNEELERERVENSKLAAK 458
                                                    |.||.||..::|.|.:::.|:|:
  Fly   515 TLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLS-- 577

  Fly   459 LAELEGQLVRGGK-NLL--DTYS-----------ERQI-----------ELE---KKLVEIAERK 495
                   |:...| |||  ..||           |||.           ||:   :|:::..|..
  Fly   578 -------LITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENA 635

  Fly   496 KREIEIQQ-QLELQEETTL-EIRERNVSLEQE--------------------------------- 525
            .:::.::: |:..|.:|.: ::.|..:.||||
  Fly   636 LKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQI 700

  Fly   526 -------------VELKKRKLSKCYAKYLALQQELNDC-KSDH-NQDLRELEMAQNELVKELKRQ 575
                         ::.|||..|:..||.|   |||.|| |.|. ...:.|.....:||:.::...
  Fly   701 DIVCRQISAFQTQLDSKKRDFSEYVAKEL---QELQDCGKLDEMGMKIEEGTPLNDELLLQVSDS 762

  Fly   576 L-LIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEY 639
            | |....|:...|::......|.||:..| |...::..|..  ..|..........|..|...|.
  Fly   763 LDLFAAQFIKDTVRRNNEEIRKLDEQIAE-KERILNASTTK--IAKVDETMLEIQAQLERLRLER 824

  Fly   640 ALQEAKSNSPSSLRFKSEN----IVNYELEMPCRTTQ--------EYRT---------------- 676
            |..||:|   .::|.|.:|    :.|..:.....|.:        .|.|
  Fly   825 AESEAES---QAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLVSS 886

  Fly   677 PKVSASLQAVLA--------QAMQTGGDDIDIVDSHTNSLRSRLENIINANANGGAGPGAGVAVG 733
            |.::...|:.|:        :|..|..||:.  .|...:.|:......:.:.:|..|.|...:..
  Fly   887 PTITEGQQSPLSNCSCDAEDEAEDTRKDDLS--GSSEETSRTCTAGPSSGSGSGSVGIGGSGSAP 949

  Fly   734 SSIPNVRNIKSSRGL 748
            |..|:.:.|.|..|:
  Fly   950 SCTPSSQAIMSDSGV 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	156/367 (43%)
		KISc	20..351	CDD:214526	159/374 (43%)
		GBP_C	<479..576	CDD:303769	32/160 (20%)
		coiled coil	547..558	CDD:293879	5/12 (42%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	159/374 (43%)
		KISc	3..371	CDD:214526	159/374 (43%)
		Kinesin_assoc	370..478	CDD:292801	21/108 (19%)
		FHA	456..555	CDD:238017	5/98 (5%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24620at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950