Protein Alignment Klp68D and Kif19A

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Alignment Length: 822
• Identity: 236/822 - (28%)
• Similarity: 355/822 - (43%)
• Gaps: 186/822 - (22%)

  Fly     9 GTGSSQ---------TPNECVQVVVRCRPMSNRERSERSPEVVN----VYPNRGVVELQNVVDGN 60
            |:.|||         ...|.:.|.||.||  :.|.:||..||::    :|.           ||.
  Fly    16 GSNSSQGRSIATAQPAQEERLVVAVRVRP--SMEATERCIEVISGGSLLYD-----------DGG 67

  Fly    61 KEQRKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEG------- 118
            |.:.:.::||..:..:.:|..:|.....|||..||.|.|..:||||.||:|||.||.|
  Fly    68 KSRPRQYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKP 132

  Fly   119 ----------------VRGNDELMGIIPRTFEQIWLHINRTENFQFLVDVSYLEIYMEELRDLLK 167
                            |...|  :|::.|..|.|:.||...|.:...|.:||||||.|.:||||.
  Fly   133 QTSDRAPPTASCDSTDVSSQD--IGLMVRAIEDIFSHIESAEAYSCRVSISYLEIYNELIRDLLN 195

  Fly   168 PNSKHLEVRE--RGSGVYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIK 230
            |... ||:||  ||..:.|..|..|...|.::::.::..|||.||:..|..|:.||||||:..|.
  Fly   196 PGGP-LELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIM 259

  Fly   231 IEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESSPHVP 295
            :: ..|...| |.|:|.|.|||||||..||....:||:|.:.||.:|.:|||||:.|:..:.:|.
  Fly   260 VQ-ARTPLGT-KQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGGARYVN 322

  Fly   296 YRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSI----QNQPIKNEDPQD 356
            ||||||||||:::|.|..||:|||::.|.:.:.:||..||.||.||.||    ||. :..::.:|
  Fly   323 YRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNS-VYIDEFKD 386

  Fly   357 AKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDS 421
            ...|.||..:..|          |.|......|...::|:........:.:...|.       .:
  Fly   387 FPTKHYQSLVSEL----------RDEVSRLRTKMLTERPRSGAAAAAAAAAASGSA-------GT 434

  Fly   422 DPEGAESES----DKENEAEVAKSNEELERERVENSKLAAKLAELEGQLV--------------- 467
            ...||.||:    |::.:.|:....|::.....:..||..||.|.|..|:
  Fly   435 AGSGAGSEAVQEQDEQRKTELRYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDAERQHMIISH 499

  Fly   468 ---RGGKNLLDTYSERQIELEKKLV------EIAERKKREIEIQQQLELQEETTLEI---RERNV 520
               |.|| |.|...:..||.|..:.      |:|..:|   |.::..|::|.|..|:   |::.|
  Fly   500 WQGRIGK-LYDAMGDDDIESEGSVALKNAWGELAAIEK---ETRRYKEIRERTEHELEQCRQKGV 560

  Fly   521 SLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPI 585
            .||.  ||.:|..|....:.|||...:::.::| ...|:...:|:...::....|||
  Fly   561 KLED--ELPERISSDEERELLALLCRVHELEAD-KVSLQAERLARQAELRRRDLQLL-------- 614

  Fly   586 EVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQEAKSNSPS 650
                |...|.:..|:                          :...|||      .::|...:.|.
  Fly   615 ----RAERQRRLCED--------------------------IISSQRR------LIEEGNVDLPD 643

  Fly   651 SLR-----FKSE--------NIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIVD 702
            .||     ::.|        :..|||.::|...|....:|..|:|.:...|..:....:.:|.||
  Fly   644 ELRELYGLYQQEIHAGVVTPSTSNYERKLPPIYTAGSDSPGSSSSSEWSPASPLPQIDNQMDPVD 708

  Fly   703 ----SHTNSLRSRLENIINANANGGAGPGAGVAVGSSIPNVR 740
                ...|....||....:||...|         ||..|::|
  Fly   709 RVMGPPVNPRLPRLSAATSANVPAG---------GSRRPSLR 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	141/363 (39%)
		Smc	<431..>580	CDD:440809	43/175 (25%)
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	137/353 (39%)
		SMC_prok_B	<393..672	CDD:274008	68/346 (20%)