Protein Alignment Klp68D and kif4

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_957117.1
• Gene: kif4 / 393796
• ZFINID: ZDB-GENE-040426-1545
• Length: 1248
• Species: Danio rerio
• Alignment Length: 737
• Identity: 225/737 - (30%)
• Similarity: 361/737 - (48%)
• Gaps: 138/737 - (18%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLYH 84
            |:|.:||||:..:|.:|.....:|..|:.     ..|:.||.   |.||:|..:|.:..|..:::
Zfish    11 VRVALRCRPLVPKEINEGCQCCLNFVPSE-----PQVIVGND---KAFTFDYVFDPTTEQEEVFN 67

  Fly    85 EVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGV----RGNDELMGIIPRTFEQIWLHINRTEN 145
            ..|.||:|.:.:|::..:.||||||:||||:|.|.    :.|:..:|:|||...:|:....:..:
Zfish    68 TAVSPLLSGLFKGYHATVLAYGQTGSGKTFSMGGTYTSEQENEPTVGVIPRVIRRIFQEKAKRTD 132

  Fly   146 FQFLVDVSYLEIYMEELRDLL-----KPNSKHLEVRE-RGSGVYVPNLHAINCKSVEDMIKVMQV 204
            .:|::.|||||||.||:.|||     ||   .:.:|| ...|:.:..|...:..:..:|:..:::
Zfish   133 CEFVLAVSYLEIYNEEILDLLCTSKDKP---VISIREDPKDGIKIVGLTERDVLNAHEMVCCLEM 194

  Fly   205 GNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNT-IKVGKLNLIDLAGSERQSKTGASAERLK 268
            ||..||||.|.||..||||||||.|.:|.......| :.|.||:|:||||||||.||.|..:|||
Zfish   195 GNSARTVGSTAMNAASSRSHAIFTISLEQRRNGDKTDVMVSKLHLVDLAGSERQKKTKAEGDRLK 259

  Fly   269 EASKINLALSSLGNVISALAESS---PHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNE 330
            |...||..|.|||||||||.:.|   ..||||||||||||||||||||.|:|||.:.|::.|..|
Zfish   260 EGISINRGLLSLGNVISALGDESKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNIEE 324

  Fly   331 TLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKP 395
            |:.|||||.||:.|:|:|:.|.||:.|::|..:::::.|:.::
Zfish   325 TINTLRYADRARKIKNKPVLNVDPRAAEMKRLKQQVQELQVML---------------------- 367

  Fly   396 KKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERERVENSKLAAKLA 460
                        |.......||...|:|        .||.::|.:.|..|:.   :||||:.:|:
Zfish   368 ------------LHARGGVAPVLSGSEP--------AENVSKVLEQNRSLQD---QNSKLSRELS 409

  Fly   461 ELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQE 525
            |..||.....:.:| ...:...:|:.||.|:.:....::::|:.:|..|:.  |:|| ||.:.|.
Zfish   410 ESVGQTAAMFERML-MMEQTNEKLQSKLDELRQHAACKVDLQRLVETLEDQ--ELRE-NVEVIQN 470

  Fly   526 -----VELKKRK--------------------LSKCYAKYLALQQEL---NDCKSDHNQDLRELE 562
                 :||::..                    .:.|.......|.|:   .|......:|..|..
Zfish   471 LQQIILELQRESAGIAATIDAITSGNASSLEAAAHCSPSTAGAQAEICPGQDGAVPEAKDSPEAY 535

  Fly   563 MAQNELVK-ELKRQLLIIDNFVPIE---VKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGK--- 620
            .||:.|.: ::.::|:.::..:.::   ||:.....:..:..|.:::.|..||....|...|
Zfish   536 TAQHALRQAQMSKELIELNKVLALKEAFVKKMCQNDSHLEPMQTQYQESIQSLQAAVGSLQKEKE 600

  Fly   621 ------FSSKRPVSH----PQRRRPTSEY-----ALQEAKSNSPSSLRFKSENIVNYELEMPCRT 670
                  .|:|:..:.    .|||:...|.     .|::...:....|:.|..::.|
Zfish   601 DLVQTLQSAKKDTNQAKLSEQRRKRLQELEGQMTELKKKLQDQSKLLKLKESSVRN--------- 656

  Fly   671 TQEYRTPKVSASLQAVLAQAMQ 692
                 ..|::..:||:.:|.:|
Zfish   657 -----VAKLNQEIQAMKSQRVQ 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	152/344 (44%)
		Smc	<431..>580	CDD:440809	39/177 (22%)
kif4	NP_957117.1	KISc_KIF4	9..339	CDD:276823	149/338 (44%)
		SMC_prok_B	<420..794	CDD:274008	49/272 (18%)
		SMC_prok_B	<621..998	CDD:274008	13/67 (19%)
		DUF3435	<938..1082	CDD:371796