DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Klp64D

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster

Alignment Length:	693	Identity:	266/693 - (38%)
Similarity:	395/693 - (56%)	Gaps:	76/693 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKSRRPGTGSSQTPNEC--VQVVVRCRPMSNRERSERSPEVVNVYP-NRGVVELQNVVDGNKE 62
            |..:....|| ::|..:|.  |:||||.|||...|.|..:...::|.. ||.:..::.....| |
  Fly     1 MPQEEANAGT-TAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATAN-E 63

  Fly    63 QRKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMG 127
            ..|.:.:|..:|..:.|..||.:...|:|..||||:||.|.||||||||||:||.|...:.:..|
  Fly    64 PPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKG 128

  Fly   128 IIPRTFEQIWLHINRT-ENFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRERGS-GVYVPNLHA 189
            |||..|..|:.||.:. ||.:|||.|||:|||.||:|||| |...|.|||:||.. ||:|.:|..
  Fly   129 IIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSG 193

  Fly   190 INCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKI---EMCDTETNTIKVGKLNLIDL 251
            ....:.:|:..:|::|||||.||.|.||:.||||||||.|.:   |:.:.:...:::|||.|:||
  Fly   194 YVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDL 258

  Fly   252 AGSERQSKTGASAERLKEASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKT 315
            |||||||||.||.:|||||:||||:||.||||||||.: .|.|:|||:|||||||||||||||||
  Fly   259 AGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKT 323

  Fly   316 IMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQR 380
            :|.|.|.|::.||.||::|||||||||:|||:...||:|:||.|:.:||||.||::       |.
  Fly   324 VMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRK-------QL 381

  Fly   381 SEKQVTAKKQRVKKPKKETVTKEMSDSLQV----STIEQPVEDDSDPEGAESESDKENEAEVAKS 441
            .|.....::....:.:::|...|:...|::    ||| |.||  ..|:....::|.|.|....:.
  Fly   382 EEGDSLEEEPPSSEEEEDTADDELEAPLEIELESSTI-QAVE--KKPKKKREKTDAEKEELAKRK 443

  Fly   442 NE---ELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQ 503
            ||   |:|..:.|...|..||..|||:::.||:|||:....:::.||:.:.|:.:.:|.|..::|
  Fly   444 NEHQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQ 508

  Fly   504 QLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNEL 568
            .|:.:....::|.||..:|:.......:|:.:.....:.::.||.|.:.:|.::...:    .|.
  Fly   509 TLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGI----YEN 569

  Fly   569 VKELKRQL----LIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDG--------KF 621
            ::.|.|:|    |:::::||.|.:..:.....::|:..||:...::..    |:.        |.
  Fly   570 IRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYT----GNNMRKHISAHKT 630

  Fly   622 SSKRP----------------VSHPQRR-----------RPTS 637
            |.|.|                ||:|.|.           |||:
  Fly   631 SGKEPDFLDLSHVYLSYNTDGVSNPMRSKSARPRTSGVPRPTT 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	177/335 (53%)
		KISc	20..351	CDD:214526	179/338 (53%)
		GBP_C	<479..576	CDD:303769	19/96 (20%)
		coiled coil	547..558	CDD:293879	3/10 (30%)
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	176/333 (53%)
		Kinesin	26..352	CDD:278646	172/326 (53%)
		RILP-like	<437..556	CDD:304877	32/118 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437784
Domainoid	1	1.000	253	1.000	Domainoid score	I504
eggNOG	1	0.900	-	-		E2759_KOG4280
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I786
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13740at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800