DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp68D and Kif28

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001357826.1	Gene:	Kif28 / 383592	MGIID:	2686151	Length:	1033	Species:	Mus musculus

Alignment Length:	461	Identity:	159/461 - (34%)
Similarity:	251/461 - (54%)	Gaps:	76/461 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAY-------- 73
            ::.|:|.||.||.|.||::..|..|::::  .|.:.:::  ..|:|:.|.||:|..|
Mouse    14 SDSVRVAVRVRPFSQREKNSGSQCVISMH--SGNISIRD--PKNEERVKTFTFDLTYWSHDGFQK 74

  Fly    74 ----------DAS--ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELM 126
                      .||  |.|:.::|::...::.|...|:|..:.||||||:||:::|.|...|   .
Mouse    75 DEDGVLIPSDPASKFAGQSDVFHDIGRGILDSAWRGYNATLLAYGQTGSGKSYSMIGFGTN---K 136

  Fly   127 GIIPRTFEQIWLHINR-TENFQFLVDVSYLEIYMEELRDLLK----PNSKHLEVRE-RGSGVYVP 185
            |:|||..|:::..|.: .||.:..|..|.||||.|::||||.    |..  |.||| :..|.:|.
Mouse   137 GLIPRVCEELFQAIEKQKENLEPQVMFSMLEIYNEQIRDLLSRTKAPGG--LRVREDQQLGFFVE 199

  Fly   186 NLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLID 250
            .|..:.|::...:.|:::.|:|.|....||||..|||||.:..|:.:....:|...|...:|::|
Mouse   200 GLKWVPCENYAQIEKLVEQGSKIRMTASTNMNASSSRSHMLIAIQFKQVFLDTALTKRSSINMVD 264

  Fly   251 LAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESSP-----HVPYRDSKLTRLLQDSLG 310
            |||||||..:|:..:||:|.|::||:|:||||||||||:.:.     |:|||||.||:|||.:||
Mouse   265 LAGSERQRSSGSEGDRLREGSRVNLSLTSLGNVISALADLAMGKKVLHIPYRDSVLTKLLQSALG 329

  Fly   311 GNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKR---- 371
            |||:|.:||.:.|::..|.|||:|||||.|||.::|:.:.|..|           :.|..|
Mouse   330 GNSRTTLIAALSPADICYEETLSTLRYAERAKKVRNRAVINTCP-----------LARASRAENA 383

  Fly   372 -LIG--------------PQQQ---QRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVE 418
             |:|              .:||   |.:..|:..:.:|..:.:.|.:|:|..   .|..:...:.
Mouse   384 LLLGFRGAGAAEHPACFWAEQQLGNQGTWAQLLEQARREWEEQYEALTQEQK---MVRILPHLLN 445

  Fly   419 DDSDPE 424
            .:.||:
Mouse   446 VNEDPQ 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	141/356 (40%)
		KISc	20..351	CDD:214526	142/361 (39%)
		GBP_C	<479..576	CDD:303769
		coiled coil	547..558	CDD:293879
Kif28	NP_001357826.1	Motor_domain	15..370	CDD:354959	142/363 (39%)
		FHA	440..537	CDD:238017	2/12 (17%)
		KIF1B	655..693	CDD:372100
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	2	1.960