Protein Alignment Klp68D and KIFC1

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_054187052.1
• Gene: KIFC1 / 3833
• HGNCID: 6389
• Length: 674
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 120/301 - (39%)
• Similarity: 172/301 - (57%)
• Gaps: 30/301 - (9%)

  Fly    64 RKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGND-ELMG 127
            |..|::|..:...:.|..::.|:.. ||.|.|:|:..|||||||||:||||||||..|.| :|.|
Human   369 RHDFSFDRVFPPGSGQDEVFEEIAM-LVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEG 432

  Fly   128 IIPRTFEQIWLHINRT--ENFQFLVDVSYLEIYMEELRDLL-----KPNSKHLEVRERGSGV--- 182
            :|||....::......  :.:.:....||:|||.|.:||||     |......|:|..|.|.
Human   433 LIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEEL 497

  Fly   183 ------YVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTI 241
                  |||    ::|:...|.:  :.:..:||.|..|..||.|||||::|.::|. .:..:..:
Human   498 TVTNARYVP----VSCEKEVDAL--LHLARQNRAVARTAQNERSSRSHSVFQLQIS-GEHSSRGL 555

  Fly   242 KVG-KLNLIDLAGSERQSKTGA----SAERLKEASKINLALSSLGNVISALAESSPHVPYRDSKL 301
            :.| .|:|:|||||||.....|    ..|||:|...||.:||:||.||.||:....|||||:|||
Human   556 QCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKL 620

  Fly   302 TRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAK 342
            |.|||:||||::|.:|..||.|...|.:|:|.:||:||:.:
Human   621 TYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVR 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	120/301 (40%)
		Smc	<431..>580	CDD:440809
KIFC1	XP_054187052.1	SMC_prok_B	<138..>312	CDD:274008
		KISc_C_terminal	308..661	CDD:276817	120/299 (40%)