Protein Alignment Klp68D and Kif14

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_006529793.2
• Gene: Kif14 / 381293
• MGIID: 1098226
• Length: 1717
• Species: Mus musculus
• Alignment Length: 941
• Identity: 258/941 - (27%)
• Similarity: 408/941 - (43%)
• Gaps: 254/941 - (26%)

  Fly    12 SSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDAS 76
            |.:..|..|.|.||.||.|.||::|::.:||........||       :.:.::|:::  .||.|
Mouse   386 SLKVENSQVTVAVRVRPFSKREKTEKASQVVFTNGEEITVE-------HPDMKQVYSF--IYDVS 441

  Fly    77 -----------ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIP 130
                       |:|||:|..:..||:....||:|.|:|||||||:||::||.|:  |:| .||||
Mouse   442 FWSFDECHPGYASQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMGL--NEE-PGIIP 503

  Fly   131 RTFEQIWLHI--NRTENFQFLVDVSYLEIYMEELRDLLKPNSKH------LEVRERG-SGVYVPN 186
            |..|.::..|  .:|....:.:::|:.|:|.|::.|||....::      |..||.. ||.||..
Mouse   504 RFCEDLFAQIAKKQTSEVSYHLEMSFFEVYNEKIHDLLVCKGENGQRKQPLRAREHPVSGPYVEG 568

  Fly   187 LHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIK--------V 243
            |......|..|:...:::|||.|....|.||:.|||||::|  .:.|..|:|..::        .
Mouse   569 LSMNVVSSYSDIQSWLELGNKQRATAATGMNDKSSRSHSVF--TLVMTQTKTEVVEGEEHDHRIT 631

  Fly   244 GKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESS----PHVPYRDSKLTRL 304
            .::||:|||||||.|...:|.:||||...||.:|.:||.|||||:|.:    ..:|||:|.||.|
Mouse   632 SRINLVDLAGSERCSTAHSSGQRLKEGVSINKSLLTLGKVISALSEQANGKRVFIPYRESTLTWL 696

  Fly   305 LQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERL 369
            |::||||||||.|||.:.|:..|..|||:|||||::|:.|.|....|||.....::|.:.|||:|
Mouse   697 LKESLGGNSKTAMIATVSPAASNIEETLSTLRYATQARLIVNIAKVNEDMNAKLIRELKAEIEKL 761

  Fly   370 K------RLIGPQQQQRSEKQVTA-----------------------------KKQRVKKPKKET 399
            |      |.|.|::.:...:::|:                             |.|..|:.:|..
Mouse   762 KAAQRSNRNIDPERYRLCRQEITSLRMKLHQQERDMAEIQRVWKEKFEQAEKRKLQETKELQKAG 826

  Fly   400 VTKEMSDSLQ--VSTIEQP----------------------------------VEDD-------- 420
            ||.:|.:.|.  |:..|.|                                  :.||
Mouse   827 VTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEGVTTVGKHTPSSSHDIQLSGVLIADDHCTIRNFG 891

  Fly   421 --------------------SDP--------------------------EGAE-------SESDK 432
                                |:|                          :|.:       :.|:.
Mouse   892 GTVSIVPAGEAKTYVNGTHISEPTVLHHGDRVVLGGDHYFRFNHPVEVQKGKKLSSRNNLTTSEG 956

  Fly   433 ENEAEVAKSNEELERER------VENSKLAAKLAELEG-----QLVRGGKNLLDTYSERQIE-LE 485
            ..:.|.|| ||.|..:|      :::::|.||...::|     ::.:...:......||:|: ||
Mouse   957 PKDFEFAK-NELLTAQRSRLEAEIKDAQLKAKEEMMQGIQIAKEMAQQELSSQKAVYERKIQALE 1020

  Fly   486 KKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDC 550
            .:|.|.::||:.| |:..|....:...||..:::  |||||.:.||:|.   .:.||.:|.|.|.
Mouse  1021 AELREESQRKRLE-ELNNQKASHKIEELERAKQH--LEQEVYVNKRRLE---METLATKQALEDH 1079

  Fly   551 KSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPP 615
            :..|.:.|..||:.:.::.:|:  |:|          ::....:.|....|..|  :||.|.|..
Mouse  1080 RIRHARILEALEIEKQKIAEEV--QML----------QENRGNRDKTFTIQPNW--NSMKLSTMI 1130

  Fly   616 GGDGKFSSKRPVSHPQRRRPTSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVS 680
            ......|.|....:...|...|:      |..|.:|:|.::       |::...|.  :...|..
Mouse  1131 QEANAISDKFKKCYIFGRHDASD------KGRSDTSVRVRN-------LQLGISTF--WSLEKFE 1180

  Fly   681 ASLQAVLAQAMQTGGD---DI----------DIVDSHTNSLRSRLENIINANANGGAGPGAGVAV 732
            :.|.|:.......|||   |:          ||..:..:||..|....:..|..          |
Mouse  1181 SKLAAMKELYESNGGDRDEDVFCDPADEWEPDITSTPVSSLSRRRSRSLMKNRR----------V 1235

  Fly   733 GSSIPNVRNIKS-----SRGLPSAASNLDSN 758
            ...:.::..|:|     |.||....|.:.||
Mouse  1236 SGCLHDIHPIQSMQSSHSSGLMEKPSTIYSN 1266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	142/362 (39%)
		Smc	<431..>580	CDD:440809	45/160 (28%)
Kif14	XP_006529793.2	KISc_KIF1A_KIF1B	392..743	CDD:276816	142/364 (39%)
		Kinesin_assoc	740..859	CDD:465047	24/118 (20%)
		FHA_KIF14	829..936	CDD:438759	9/106 (8%)
		SMC_prok_B	<937..>1109	CDD:274008	47/190 (25%)