Protein Alignment Klp68D and KIF5A

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_004975.2
• Gene: KIF5A / 3798
• HGNCID: 6323
• Length: 1032
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 216/620 - (34%)
• Similarity: 332/620 - (53%)
• Gaps: 71/620 - (11%)

  Fly    13 SQTPNEC-VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDAS 76
            ::|.||| ::|:.|.||: |:....|..:.:.::.....|    |:.|     |.:.:|..:..:
Human     2 AETNNECSIKVLCRFRPL-NQAEILRGDKFIPIFQGDDSV----VIGG-----KPYVFDRVFPPN 56

  Fly    77 ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI- 140
            .||..:||.....:|..||.|:||.|||||||.:|||.||||...:.:|||||||....|:.||
Human    57 TTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIY 121

  Fly   141 NRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGV-YVPNLHAINCKSVEDMIKVMQV 204
            :..||.:|.:.|||.|||::::||||.....:|.|.|..:.| :|.........|.|:::.|:..
Human   122 SMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDE 186

  Fly   205 GNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKE 269
            |..||.|..|||||||||||:||:|.|:..:.||.....|||.|:||||||:.|||||....|.|
Human   187 GKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDE 251

  Fly   270 ASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLT 333
            |..||.:||:|||||||||| :..:|||||||:||:||||||||.:|.|.....||:||..||.:
Human   252 AKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKS 316

  Fly   334 TLRYASRAKSIQNQPIKN-EDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAK--------K 389
            ||.:..|||:|:|....| |...:...|:|::|.|:.|          ::|:..||        :
Human   317 TLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTK----------AQKETIAKLEAELSRWR 371

  Fly   390 QRVKKPKKETVTKEMSDSLQVSTIEQ-PVEDDSD------PEGAESESDKENEAEVAKSNEELER 447
            .....|:.|.:..|.: :|.....|: ||.|:|.      ||  |.:..:|....:.|..::.:.
Human   372 NGENVPETERLAGEEA-ALGAELCEETPVNDNSSIVVRIAPE--ERQKYEEEIRRLYKQLDDKDD 433

  Fly   448 ERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEI-AERKKREIEIQQQLELQEET 511
            |..:.|:|..||.:   |::...:.|:.|..:.: :::::|..: :|....:.|:::.|:..||.
Human   434 EINQQSQLIEKLKQ---QMLDQEELLVSTRGDNE-KVQRELSHLQSENDAAKDEVKEVLQALEEL 494

  Fly   512 TLEIRERNVSLEQEVELKKR-------KLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELV 569
            .:...:::    ||||.|.:       :||:..|..|:|:.||...:.......:.:....|.|:
Human   495 AVNYDQKS----QEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLM 555

  Fly   570 KELKRQLLIIDN---FVPIEVK---------QRLY 592
            |:|....:|:.|   .:|:|:.         .|||
Human   556 KDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLY 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	151/333 (45%)
		Smc	<431..>580	CDD:440809	33/156 (21%)
KIF5A	NP_004975.2	KISc_KHC_KIF5	7..327	CDD:276820	151/329 (46%)
		Microtubule-binding	174..315		80/140 (57%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250|UniProtKB:P33175	271..361		41/99 (41%)
		Interaction with BICD2. /evidence=ECO:0000269|PubMed:20386726	353..1032		55/259 (21%)
		PRK03918	<409..920	CDD:235175	42/192 (22%)
		Khc_CBD_cc	832..901	CDD:467880
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	906..939
		Globular	907..1032
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	978..1010