DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp68D and KIF3C

DIOPT Version :9

Sequence 1:NP_001261726.1 Gene:Klp68D / 39332 FlyBaseID:FBgn0004381 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_002245.4 Gene:KIF3C / 3797 HGNCID:6321 Length:793 Species:Homo sapiens


Alignment Length:722 Identity:313/722 - (43%)
Similarity:450/722 - (62%) Gaps:75/722 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 SSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDAS 76
            |....:|.::||.||||:|.:|.:....:::.:....|.|.|:|......|..|.||:||.||||
Human     3 SKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDAS 67

  Fly    77 ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHIN 141
            :.|..||.|.|.||:.|||:||||.:|||||||||||:||:|.....||.|:||..||.|:.||:
Human    68 SKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHIS 132

  Fly   142 RTENFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRER-GSGVYVPNLHAINCKSVEDMIKVMQV 204
            |::|.|:||..||||||.||:|||| |...|.||::|. .:|||:.:|.:...|:|:::..||.:
Human   133 RSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNL 197

  Fly   205 GNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTET---NTIKVGKLNLIDLAGSERQSKT------ 260
            ||:.|.||.|:|||.||||||||:|.:|..:..:   :.|:||||||:||||||||:|.      
Human   198 GNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAG 262

  Fly   261 ------------------GASAERLKEASKINLALSSLGNVISALA-ESSPHVPYRDSKLTRLLQ 306
                              ||..||.||||||||:||:|||||:||| ..|.|:||||||||||||
Human   263 GAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQ 327

  Fly   307 DSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKR 371
            ||||||:||||:|.:||::::|:|:|:|||:|:|||:|:|:|..||||:|..|:|:||||.|||.
Human   328 DSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKA 392

  Fly   372 ------LIGPQQQQRS---EKQVTA----------------------KKQRVKKPKKET-VTKEM 404
                  ::|.:.:::|   :|.|:|                      ...|..:|..|: :.|.|
Human   393 QLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESALEKNM 457

  Fly   405 SDSLQVSTIEQPVEDD----SDPEGAESESDKENEAEVAKSNEELERERVENSKLAAKLAELEGQ 465
            .:.||..  ::.:|::    .|.....||..::...|..|..|:|.||:.....||||...:|.:
Human   458 ENYLQEQ--KERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESK 520

  Fly   466 LVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKK 530
            |:.||:|::|..:|:|..||.|..||||:|:||.|:||::.|::|.|:|:|....||:||||:|.
Human   521 LLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKT 585

  Fly   531 RKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQA 595
            :||.|.|||..|::.|:.|...::.:..::||.||||..:|||.:.|||:||:|.|.|.::..:.
Human   586 KKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRL 650

  Fly   596 KYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYA-LQEAKSNSPSSLRFKSENI 659
            ..|.|:|:|||..:   .|.|.......|||.|....:||.|:|| :..|..:.|   |:::|||
Human   651 FLDCEEEQWKFQPL---VPAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHP---RYRAENI 709

  Fly   660 VNYELEM 666
            :..||::
Human   710 MFLELDV 716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp68DNP_001261726.1 Motor_domain 18..344 CDD:277568 185/355 (52%)
KISc 20..351 CDD:214526 187/360 (52%)
GBP_C <479..576 CDD:303769 45/96 (47%)
coiled coil 547..558 CDD:293879 1/10 (10%)
KIF3CNP_002245.4 KISc_KIF3 9..365 CDD:276822 185/355 (52%)
Kinesin 16..365 CDD:278646 182/348 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 251..288 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 395..424 5/28 (18%)
GBP_C <461..569 CDD:303769 40/109 (37%)
coiled coil 538..549 CDD:293879 6/10 (60%)
coiled coil 558..569 CDD:293879 4/10 (40%)
Globular. /evidence=ECO:0000255 630..793 33/93 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 750..793
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146962
Domainoid 1 1.000 229 1.000 Domainoid score I2476
eggNOG 1 0.900 - - E2759_KOG4280
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 613 1.000 Inparanoid score I915
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D145782at33208
OrthoFinder 1 1.000 - - FOG0002745
OrthoInspector 1 1.000 - - otm41123
orthoMCL 1 0.900 - - OOG6_101005
Panther 1 1.100 - - O PTHR24115
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2170
SonicParanoid 1 1.000 - - X1829
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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