DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp68D and Klp59C

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	143/460 - (31%)
Similarity:	214/460 - (46%)	Gaps:	65/460 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKSRRPGTGSSQTPNECVQVVVRCRPMSNRERSERSPEVVN--------VYPNRGVVELQNVV 57
            |.::..|.||.:.:.....:.|.||.||:..:|.::|..:||:        |:..|..|.|...:
  Fly   169 MESQRVRSGTTNERINCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFL 233

  Fly    58 DGNKEQRKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGV--- 119
            :.:.     |.:|..:|...:..|:|.....||:..:.:|.....|||||||:|||:||.|.
  Fly   234 ENHS-----FRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPG 293

  Fly   120 RGNDELMGIIPRTFEQIWLHINRT--ENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRE-RGSG 181
            |....:.||.....:.::..:...  ......|..|:.|||...:.|||.|....|.|.| |...
  Fly   294 RHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQ 358

  Fly   182 VYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKV-GK 245
            |.|..|.....::..:::.::::||..||.|.|:.|..||||||:|.|.:.....|    |: ||
  Fly   359 VQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGE----KLHGK 419

  Fly   246 LNLIDLAGSERQSKTGASAERLK--EASKINLALSSLGNVISALAESSPHVPYRDSKLTRLLQDS 308
            .:||||||:|| ....:||:|..  |.|:||.:|..|...|.||...|.|:|:|.||||::|:||
  Fly   420 FSLIDLAGNER-GADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDS 483

  Fly   309 -LGGNS-KTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKE-------YQE 364
             :||.. ||.|||.|.|..::...||.|||||.|.|.:..:.|.::...||.|..       .|.
  Fly   484 FIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKELSVESIPSKRMPDANLGSTSMSDIVCQS 548

  Fly   365 EIERLKRLI--------GPQQQQ---------RSEK------------QVTAKKQRVKKPKKETV 400
            ..:||....        |.|.||         ||:|            |:..:|...::.....:
  Fly   549 STQRLFPCASSTSMPGGGNQAQQHTNTANDLNRSQKPTSKPTYPTSGQQLVQRKGSSQREASMML 613

  Fly   401 TKEMS 405
            ||.::
  Fly   614 TKSLA 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	121/344 (35%)
		KISc	20..351	CDD:214526	122/349 (35%)
		GBP_C	<479..576	CDD:303769
		coiled coil	547..558	CDD:293879
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	120/341 (35%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	118/336 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437840
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940