Protein Alignment Klp68D and unc-104

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 924
• Identity: 258/924 - (27%)
• Similarity: 407/924 - (44%)
• Gaps: 230/924 - (24%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAY------DAS-A 77
            |:|.||.||.::||.:..|..::.:......:....|.....:..|.|.:|.:|      ||. :
  Fly     4 VKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDADFS 68

  Fly    78 TQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINR 142
            ||:.:|.::...::....:|:|.|||||||||.||::||.| |..::..||||...:.::..|..
  Fly    69 TQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMG-RQEEQQEGIIPMICKDLFTRIQD 132

  Fly   143 TE--NFQFLVDVSYLEIYMEELRDLLKPNSK-HLEVRERG-SGVYVPNLHAINCKSVEDMIKVMQ 203
            ||  :.::.|:|||:|||.|.:||||.|.:| :|.|||.. .|.||.:|..:.....:|:..::.
  Fly   133 TETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDLID 197

  Fly   204 VGNKNRTVGFTNMNEHSSRSHAIFMIKI--EMCDTETN--TIKVGKLNLIDLAGSERQSKTGASA 264
            .|||.|||..|||||.||||||:|.|..  ...|..||  |.||.|::|:|||||||...|||..
  Fly   198 EGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGAKG 262

  Fly   265 ERLKEASKINLALSSLGNVISALAE---------SSPHVPYRDSKLTRLLQDSLGGNSKTIMIAN 320
            .||||.:.||.:|::||.|||||||         .:..:|||||.||.||:::|||||||.|||.
  Fly   263 TRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTAMIAA 327

  Fly   321 IGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQV 385
            |.|::.||:|||:|||||.|||.|..:.:.|||.....::|.:|||::|:.|:..:..:..|:..
  Fly   328 ISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEEDE 392

  Fly   386 TAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNE-ELERER 449
            ..|...:|.|.|       |.:...||.|..|:.....|...:|.::..|.::.::.| .::||.
  Fly   393 LTKSTVIKSPTK-------SRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREA 450

  Fly   450 V-ENSKLAAK-------------------------LAELEGQLVRGGKNLLDTYS---ERQIELE 485
            | ....:|.|                         |:|.....::.|...|.|:.   .:.|:|.
  Fly   451 VFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLS 515

  Fly   486 --------------------------------KKLV--EIAERKKREI----------------E 500
                                            :|||  |:.:...|.|                |
  Fly   516 GSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARE 580

  Fly   501 IQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQ 565
            ::.::|.:.|...|:.:.:.   |:|:..       :|:...|:::..|.|::..:.|..||
  Fly   581 LRDKIETENEAENEVEKTDT---QQVDWN-------FAQCELLEKQGIDLKAEMKKRLDNLE--- 632

  Fly   566 NELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHP 630
                ::.||:.|..|.  ..|.:::.| :|:.|..|::.:..||::       ..:||..|....
  Fly   633 ----EQYKREKLQADQ--QFEEQRKTY-EARIDALQKQVEEQSMTM-------SMYSSYSPEDFH 683

  Fly   631 Q----------------RRRPTSEYALQEAKSNSPSSLR---------FKSENIVNYELE----- 665
            |                |....:.:|.::.:.:..:|||         .|..|.::.||:
  Fly   684 QEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQF 748

  Fly   666 ---------------------MPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIVDSH---TN 706
                                 .|.....|:..|.||.:|.||.....:.|.       :|   ..
  Fly   749 QFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGA-------THHWSLE 806

  Fly   707 SLRSRLE---NIINANANGGAGPGAGVAVGSS----------------------IPNVRNIKSSR 746
            .||.|||   .|.|..:     |.:.:...:|                      :|....::|.|
  Fly   807 KLRYRLELMRQIYNVES-----PPSSMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESER 866

  Fly   747 GLPSAASNLDSNRR 760
            |..:.|:.:.|.:|
  Fly   867 GRLTLANLIPSRQR 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	154/354 (44%)
		Smc	<431..>580	CDD:440809	36/228 (16%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	154/354 (44%)
		Kinesin_assoc	355..498	CDD:465047	30/149 (20%)
		FHA_KIF1	474..574	CDD:438757	13/99 (13%)
		YhaN	<575..>666	CDD:443752	22/110 (20%)
		KIF1B	878..924	CDD:463574	1/3 (33%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939