DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Khc

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	790	Identity:	250/790 - (31%)
Similarity:	369/790 - (46%)	Gaps:	141/790 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKSRRPGTGSSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQR- 64
            |||:...|...|       ::||.|.||:::.|....|..||. :||            |.|:.
  Fly     1 MSAEREIPAEDS-------IKVVCRFRPLNDSEEKAGSKFVVK-FPN------------NVEENC 45

  Fly    65 -----KVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDE 124
                 ||:.:|..:..:|:|..:|:|....:|:.||.|:||.|||||||.:|||.|||||.|:..
  Fly    46 ISIAGKVYLFDKVFKPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSV 110

  Fly   125 LMGIIPRTFEQIWLHINRTE-NFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGV-YVPNL 187
            ..|||||....|:.||...| |.:|.:.|||.||||:::||||..:..:|.|.|..:.| ||...
  Fly   111 KQGIIPRIVNDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGA 175

  Fly   188 HAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLA 252
            ......|.||:.:|::.|..||.:..|||||||||||::|:|.::..:.|......|||.|:|||
  Fly   176 TERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLA 240

  Fly   253 GSERQSKTGASAERLKEASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTI 316
            |||:.|||||....|.||..||.:||:|||||||||: :..|:|||||||||:||:|||||::|.
  Fly   241 GSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTT 305

  Fly   317 MIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLK-EYQEEIERLKRLIGPQQQQR 380
            ::....|:::|.:||.:||.:..|||:::|....||:....:.| .|::|.|:..||.|     :
  Fly   306 IVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKG-----K 365

  Fly   381 SEK-QVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEE 444
            .|| ::...:.|..:..|......|.|.::.||....||                .|:.|.:...
  Fly   366 VEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLEVE----------------AAQTAAAEAA 414

  Fly   445 LERERV------------ENSKLAAKLAELEGQLVRGGK--NLLDTYSERQIELEKKLVEIAERK 495
            |..:|.            |.::||.:...|..||....:  |....|:|:..|...:..|:....
  Fly   415 LAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANA 479

  Fly   496 KREIE--------IQQQLELQEETTLEIRERNVSLE----------QEVELKKRKLSKCYAKYLA 542
            :||.|        |||:.|..:|   |::|...:||          ||::.|.:.:.       |
  Fly   480 RREYETLQSEMARIQQENESAKE---EVKEVLQALEELAVNYDQKSQEIDNKNKDID-------A 534

  Fly   543 LQQELNDCKSDHN------QDLRELEMAQNELVKELKRQLL-----IIDNFVPIE--VKQRLYTQ 594
            |.:||...:|..|      |.|:::...|.:.:.|:...||     :.....|.|  :..::...
  Fly   535 LNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSAL 599

  Fly   595 AKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQEAKSN------------ 647
            |..|..:.|..|:...|         |.||.........:..|....|:|.||
  Fly   600 AGTDASKVEEDFTMARL---------FISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGE 655

  Fly   648 -----SPSSLRFKSENIVNYELEMPCRTTQEY------RTPKVSAS--LQAVLAQAMQTGGDDID 699
                 |....|.||......|.|...||.:|.      ...|:.|:  :.||.|:..|...:...
  Fly   656 YRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRS 720

  Fly   700 IVDSHTNSLR 709
            :.||..:.||
  Fly   721 MFDSQMDELR 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	149/334 (45%)
		KISc	20..351	CDD:214526	150/339 (44%)
		GBP_C	<479..576	CDD:303769	28/120 (23%)
		coiled coil	547..558	CDD:293879	4/16 (25%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	150/342 (44%)
		KISc	12..340	CDD:214526	151/347 (44%)
		Apolipoprotein	595..744	CDD:279749	32/145 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24620at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950