DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp68D and Khc-73

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster

Alignment Length:	970	Identity:	256/970 - (26%)
Similarity:	395/970 - (40%)	Gaps:	333/970 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVE----LQNVVDGNKEQRKVFTYDAAY------- 73
            ::|.||.||.:.||....:..:|.:...:.:::    |:.:   .::|.|.|.:|..:
  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKI---ERKQPKTFAFDHCFYSLNPED 67

  Fly    74 DASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWL 138
            :..|:|.|::..|...::.:..:|:|.|||||||||:||::||   .|..|..|||||..:|::.
  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTM---MGTQESKGIIPRLCDQLFS 129

  Fly   139 HI--NRTENFQFLVDVSYLEIYMEELRDLL--KPNSKHLEVRERG-SGVYVPNLHAINCKSVEDM 198
            .|  ..|....:.|:|||:|||.|::.|||  |||.:.|:|||.. .|.||..|..:...|.:|:
  Fly   130 AIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDI 194

  Fly   199 IKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNT----IKVGKLNLIDLAGSERQSK 259
            ..:|..|||:|||..||||..||||||:|.:.:....|:..|    .||.:::|:|||||||..|
  Fly   195 DNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVK 259

  Fly   260 TGASAERLKEASKINLALSSLGNVISALAESS--------PHVPYRDSKLTRLLQDSLGGNSKTI 316
            |||..:||||.|.||.:|::||.|||.||:.|        ..||||||.||.||:|:|||||:|:
  Fly   260 TGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTV 324

  Fly   317 MIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRL--------I 373
            |:|.|.||..||.|||:|||||.|||.|.|..:.||||....::|.:.|:|.|:.:        :
  Fly   325 MVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPV 389

  Fly   374 GPQQQQRSE-----KQVT-------AKKQRVKKPKKETVTKEMSDSLQVSTI------------- 413
            |..|.:.:|     ||::       .|.:|::..:::.:.| |..|:|.|.|
  Fly   390 GDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEK-MGISVQASGIKVEKNKYYLVNLN 453

  Fly   414 --------------------------EQP-----------------VEDDS---DP-EGAES--- 428
                                      :||                 :||..   :| :||..
  Fly   454 ADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVN 518

  Fly   429 --------------------------ESDKENEAEVAKS--------------NEELERERVENS 453
                                      .|.|.|...:..|              .:|:.:..:.|.
  Fly   519 GSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSND 583

  Fly   454 KLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTL----- 513
            .:...:|.||.|          ...::|:.|||      :|::.|.:.||...:...:|.
  Fly   584 PIQTAIARLERQ----------HEEDKQVALEK------QRQEYERQFQQLRNILSPSTPYAPYA 632

  Fly   514 --------EIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVK 570
                    :|.....:.:..||...::..:.:      ::.|...|:|        .|..|.||:
  Fly   633 PYDPLRMGKITPNTPTSQMRVEKWAQERDEMF------RRSLGQLKTD--------IMRANSLVQ 683

  Fly   571 ELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRP 635
            |.        ||:.             :|.:::.|| |::|..||..          ..|.|||.
  Fly   684 EA--------NFLA-------------EEMEKKTKF-SVTLQIPPAN----------LSPNRRRG 716

  Fly   636 --TSEYALQEAKSNSPSSLRFKSENIVNYELEM------------------------PCRTTQE- 673
              .||.|:...::||.|.: :..|.:.|..::|                        |...:||
  Fly   717 AFVSEPAILVKRTNSGSQI-WTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQEN 780

  Fly   674 ---------------------YRTPKVS----------ASLQAVLAQAMQ---------TGGDD- 697
                                 |.||.:|          ..::.:..|..|         :.||.
  Fly   781 HNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSR 845

  Fly   698 ---IDIVDSHTNSLRSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRGLPSAASN 754
               .|.||..:|.:..|:                            .||.:.|||.:.||
  Fly   846 DEYDDPVDPTSNQITCRV----------------------------TIKCASGLPLSLSN 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	151/351 (43%)
		KISc	20..351	CDD:214526	153/358 (43%)
		GBP_C	<479..576	CDD:303769	20/109 (18%)
		coiled coil	547..558	CDD:293879	3/10 (30%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	153/358 (43%)
		KISc	6..359	CDD:214526	153/358 (43%)
		Kinesin_assoc	356..468	CDD:292801	21/112 (19%)
		FHA	446..546	CDD:238017	7/99 (7%)
		KIF1B	741..786	CDD:289208	5/44 (11%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940