Protein Alignment Klp68D and Kif18a

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001421255.1
• Gene: Kif18a / 362186
• RGDID: 1561740
• Length: 886
• Species: Rattus norvegicus
• Alignment Length: 864
• Identity: 237/864 - (27%)
• Similarity: 382/864 - (44%)
• Gaps: 185/864 - (21%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVV-------------ELQNVVDGNKEQRK--VFTY 69
            ::||||.||.:.:|::.:..:||:|.....:|             :.....|..|.|.|  .|.:
  Rat    12 MKVVVRVRPENTKEKAVQFHKVVHVVDKHILVFDPKQEEISFFHRKKTTNFDITKRQNKDLKFVF 76

  Fly    70 DAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFE 134
            ||.:|.::||..::.....|::.|.|.|:|..:||||.||:|||.||.|            .|.|
  Rat    77 DAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLG------------STAE 129

  Fly   135 QIWLHINRTENFQFLVD----------VSYLEIYMEELRDLLKPNSKHLEVRERG-SGVYVPNLH 188
            ...:::...:.|:.:.:          |||||:|.|::|||| .||..|.|||.. .||.|..|.
  Rat   130 PGVMYLTMLDLFKCMDEVKDEKECSTAVSYLEVYNEQIRDLL-TNSGPLAVREDAQKGVVVQGLT 193

  Fly   189 AINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETN---TIKVGKLNLID 250
            ....||.|::::::..||||||...|:||..||||||:|.|.:...|...:   .:.:.|::|||
  Rat   194 LHQPKSSEEILQLLDNGNKNRTQHPTDMNAASSRSHAVFQIYLRQQDKTASINQNVHIAKMSLID 258

  Fly   251 LAGSERQSKTGASAERLKEASKINLALSSLGNVISALAES---SPHVPYRDSKLTRLLQDSLGGN 312
            ||||||.|.:|....|..|.:.||.:|.:|||||:|||::   :.|:|||:|||||||:||||||
  Rat   259 LAGSERASISGTKGTRFVEGTNINKSLLALGNVINALADTKRRNQHIPYRNSKLTRLLKDSLGGN 323

  Fly   313 SKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQ 377
            .:|||||.:.||:..|::|..||:||:|||.|::..:|      :.:......|.:..::...|
  Rat   324 CQTIMIAAVSPSSLFYDDTYNTLKYANRAKDIKSSQLK------SNVVNLSSHISQYVKICNMQ- 381

  Fly   378 QQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSN 442
                :.::...|:::|..:.:....:.:|..::  :...|||                .|:.:..
  Rat   382 ----KAEILMLKEKLKAYEGQKALTDRNDCAKL--VHSNVED----------------KEIERFQ 424

  Fly   443 EEL-----ERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIEL---EKKLVEIAERKKREI 499
            |.|     .||.:....|..::...|.:|    |:.......:|||:   |.||.:...|:...:
  Rat   425 EILNCLFQNREGMRQEYLKVEMLLKENEL----KSSYHQQCHKQIEMMCSEDKLEKATCRRDHRL 485

  Fly   500 EIQQQ----LELQEETTLEIRERNVSLEQEVELKKRKLSK-----------CYAKYLALQQELND 549
            |..:.    ||.::|..|:..:.|.:....||.:.|.|.:           .:..:|.||.:...
  Rat   486 EKLKSNRCVLEKKKEEMLKQFDENTNWLHRVESEMRLLGQNGDIPEGLNKDLHCHHLHLQNKDLK 550

  Fly   550 CKSDHNQDLRELEMAQ--------NELVKELKRQLLII-----------DNFVPIE-VKQRLYTQ 594
            .:..|...|..|:..|        |.|:..|::|...:           .:|..|| :.:|....
  Rat   551 TQMGHMMTLAALQEQQHGQTEAVLNALLPVLRKQYWRLKETGLSNAAFDSDFKDIEHLVERKKVV 615

  Fly   595 AKYDEEQEEWK------------------------FSSMSLP-----TPPGGDGKFSSKRPVSHP 630
            |..|:..|...                        .||||.|     ||.    :.:.::.:..|
  Rat   616 AWADQTAEHSNQSDVPGTSLLMTFPQLGPIQSIPCCSSMSDPSILKITPQ----RRTKRKLIPSP 676

  Fly   631 QRRRPTSEYALQEAKSNSPSSLRFKSE-NIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTG 694
            .:.:.|.:.||.|....:.|   |..| ..:.|..|...||.|:...|...||..:.      .|
  Rat   677 LKVKHTQKSALSERTQLNDS---FSKELQPIVYTPEDSRRTVQDLSPPLARASSHSA------NG 732

  Fly   695 GDDIDIVDSHTNSLRS--RLEN-IINANANGGAGPGAGVAVGSSIPNVRNIKSS--RGLPSAASN 754
            .:|        |||::  |.|: :.......|....:.:..|     ::::|::  ..|||:.|.
  Rat   733 MND--------NSLKALCRTESPLSRTECKEGLYSTSAICDG-----IKSLKNNLPEPLPSSKST 784

  Fly   755 LDSNRRPPTGRLPAKKPAS 773
            |   .|..:...|.|...|
  Rat   785 L---HRVESSSFPTKDSRS 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	142/362 (39%)
		Smc	<431..>580	CDD:440809	37/190 (19%)
Kif18a	NP_001421255.1	KISc_KIP3_like	11..355	CDD:276821	141/355 (40%)