DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and cos

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	166/755 - (21%)
Similarity:	300/755 - (39%)	Gaps:	195/755 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 AYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEG-VRG---NDELMGIIPRT 132
            |..:|::|..:||:.||||::..||||:..:..|||.|.||::|:.| |:.   .|...|::...
  Fly   141 ALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLC 205

  Fly   133 FEQIWLHINRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGVYVPNLHAINCKSVED 197
            ...|:.||:......:.::|.::||...::.|||            |.|    |:|   |.:|:.
  Fly   206 VRDIFSHISLHPERTYAINVGFVEICGGDVCDLL------------GMG----NIH---CTNVDA 251

  Fly   198 MIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTI---KVGKLNLIDLAGSERQSK 259
            :...:|||...|         .|..:|.:|.:.:|........:   ::...:..||.|:||...
  Fly   252 VFHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFSDLCGTERCGD 307

  Fly   260 TGASAERLKEASKINLALSSLGNVISALAES------SPHVPYRDSKLTRLLQDSLGGNSKTIMI 318
            .       .....::..|..|..|||.|.:.      :.::||..:.||.||:||.||.::|::|
  Fly   308 Q-------PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVI 365

  Fly   319 ANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQD-AKLKEYQEEIERLKRLIGPQQQ---- 378
            ..:.|...:..|||..|::|.:.:.::|..|.|....| ..:.:..|.:.......||..|
  Fly   366 LCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPVPESNSSAGPLSQAGPG 430

  Fly   379 ---------QRSEKQVT-----------------AKKQRVKK---PKKE-----TVTKEMSDSLQ 409
                     .:..|.||                 .:|:::::   .|:|     :.|:.|....|
  Fly   431 DNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLSSTEAMRQQKQ 495

  Fly   410 VSTI---EQPVEDDSDPEGAESE---SDKENEAEVAKSNEELERERVENSKLAAKLAELEGQLVR 468
            :..|   |:|  :|.:.|.|.||   ||.||:.:......:|: :::|:  |..:..:....|:
  Fly   496 LVPILEAEEP--EDVNSEAANSESPNSDNENDTDNESHRPDLD-DKIES--LMEEFRDKTDALI- 554

  Fly   469 GGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKL 533
                 |:.::|   .|.|....:.:.:.||||.|...|..::..:.|..|..|::....|...:|
  Fly   555 -----LEKHAE---YLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAEL 611

  Fly   534 SKCYAKYLALQQE---------LNDCKSDHNQDLRELEMAQ-------NELVKELKRQLLIIDNF 582
            :  ....:|.||.         ::..:|...:.:|:..:|.       .:|.|:|::  |:.:
  Fly   612 A--MLNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKKLRK--LVAE-- 670

  Fly   583 VPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQEAKSN 647
              ||.|||   |.:..||..:.|                  :..::...:...|..:|.|
  Fly   671 --IEGKQR---QLREIEETIQVK------------------QNIIAELVKNSDTRSHAKQ----- 707

  Fly   648 SPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDI-----VDSHTNS 707
                 ||..:..   :||..|...::.            |.:|:..|.|..:|     :..|
  Fly   708 -----RFHKKRA---KLEAECDKAKKQ------------LGKALVQGRDQSEIERWTTIIGH--- 749

  Fly   708 LRSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRG 747
            |..|||::.:...          ..|.|...|:.::.|.|
  Fly   750 LERRLEDLSSMKH----------IAGESGQKVKKLQQSVG 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	76/284 (27%)
		KISc	20..351	CDD:214526	78/291 (27%)
		GBP_C	<479..576	CDD:303769	23/112 (21%)
		coiled coil	547..558	CDD:293879	1/10 (10%)
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	76/282 (27%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	36/188 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437876
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030