Protein Alignment Klp68D and cos

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_477092.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Alignment Length: 755
• Identity: 166/755 - (21%)
• Similarity: 300/755 - (39%)
• Gaps: 195/755 - (25%)

  Fly    72 AYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEG-VRG---NDELMGIIPRT 132
            |..:|::|..:||:.||||::..||||:..:..|||.|.||::|:.| |:.   .|...|::...
  Fly   141 ALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLC 205

  Fly   133 FEQIWLHINRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGVYVPNLHAINCKSVED 197
            ...|:.||:......:.::|.::||...::.|||            |.|    |:|   |.:|:.
  Fly   206 VRDIFSHISLHPERTYAINVGFVEICGGDVCDLL------------GMG----NIH---CTNVDA 251

  Fly   198 MIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTI---KVGKLNLIDLAGSERQSK 259
            :...:|||...|         .|..:|.:|.:.:|........:   ::...:..||.|:||...
  Fly   252 VFHWLQVGLSAR---------QSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFSDLCGTERCGD 307

  Fly   260 TGASAERLKEASKINLALSSLGNVISALAES------SPHVPYRDSKLTRLLQDSLGGNSKTIMI 318
            .       .....::..|..|..|||.|.:.      :.::||..:.||.||:||.||.::|::|
  Fly   308 Q-------PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVI 365

  Fly   319 ANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQD-AKLKEYQEEIERLKRLIGPQQQ---- 378
            ..:.|...:..|||..|::|.:.:.::|..|.|....| ..:.:..|.:.......||..|
  Fly   366 LCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPVPESNSSAGPLSQAGPG 430

  Fly   379 ---------QRSEKQVT-----------------AKKQRVKK---PKKE-----TVTKEMSDSLQ 409
                     .:..|.||                 .:|:::::   .|:|     :.|:.|....|
  Fly   431 DNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLSSTEAMRQQKQ 495

  Fly   410 VSTI---EQPVEDDSDPEGAESE---SDKENEAEVAKSNEELERERVENSKLAAKLAELEGQLVR 468
            :..|   |:|  :|.:.|.|.||   ||.||:.:......:|: :::|:  |..:..:....|:
  Fly   496 LVPILEAEEP--EDVNSEAANSESPNSDNENDTDNESHRPDLD-DKIES--LMEEFRDKTDALI- 554

  Fly   469 GGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKL 533
                 |:.::|   .|.|....:.:.:.||||.|...|..::..:.|..|..|::....|...:|
  Fly   555 -----LEKHAE---YLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAEL 611

  Fly   534 SKCYAKYLALQQE---------LNDCKSDHNQDLRELEMAQ-------NELVKELKRQLLIIDNF 582
            :  ....:|.||.         ::..:|...:.:|:..:|.       .:|.|:|::  |:.:
  Fly   612 A--MLNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKKLRK--LVAE-- 670

  Fly   583 VPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQEAKSN 647
              ||.|||   |.:..||..:.|                  :..::...:...|..:|.|
  Fly   671 --IEGKQR---QLREIEETIQVK------------------QNIIAELVKNSDTRSHAKQ----- 707

  Fly   648 SPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDI-----VDSHTNS 707
                 ||..:..   :||..|...::.            |.:|:..|.|..:|     :..|
  Fly   708 -----RFHKKRA---KLEAECDKAKKQ------------LGKALVQGRDQSEIERWTTIIGH--- 749

  Fly   708 LRSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRG 747
            |..|||::.:...          ..|.|...|:.::.|.|
  Fly   750 LERRLEDLSSMKH----------IAGESGQKVKKLQQSVG 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	78/291 (27%)
		Smc	<431..>580	CDD:440809	32/164 (20%)
cos	NP_477092.1	Kinesin	140..389	CDD:459720	76/282 (27%)
		SMC_N	660..>999	CDD:481474	36/185 (19%)