DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and CG5004

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster

Alignment Length:	749	Identity:	144/749 - (19%)
Similarity:	259/749 - (34%)	Gaps:	269/749 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IYMEE--------LRDLL-KPNSKHLEVRERGSGVYVPNLHAINCKSVEDMIKVMQVGNKNRTVG 212
            ||.|:        .:||| |.|:...:...:..|:.:.:::.:|    .|:......||.:.|.|
  Fly   238 IYKEQHQQQHQQAPQDLLTKVNNDRYDRYPKAGGLQIYSMNGVN----SDINNGPATGNNSGTGG 298

  Fly   213 FTNMNEHSSRSHAIFMIKI--EMCDTET---NTIKVGKLNLIDLAG-SERQSKTGASAERLKEAS 271
            ...:.:         |:||  |..|...   :|..|...:.|..:. .:.:.||..|..|.|..|
  Fly   299 GAELED---------MLKICTEYADRNNSMPSTHNVSSTSSITSSPIVQNRIKTNGSLPRDKNKS 354

  Fly   272 KI--NLALSSLGNVISALAESSP------------------HVPYRDSKLTRLLQDSLGGNSKTI 316
            ..  ...::|..| ||.|:.||.                  |||.....         ||:|..:
  Fly   355 PFPQQAGVASSAN-ISLLSSSSGYENVRLLGPNRVEINGQIHVPASAGD---------GGSSSGV 409

  Fly   317 MIANIGPS--------NYNYNETLTT----LRYASRAK--------------------------- 342
            ....:.|:        |.|.|.:.||    :..:.|.|
  Fly   410 SSNALAPTAAVRASHENLNQNHSATTGGKYVPQSPRTKIRTNCMSPKKDVSFGNAFALAISPPPL 474

  Fly   343 ---------------SIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRV 392
                           |:...|:..:.|...:.::|::..:..:|     :||:.::.|.||:.
  Fly   475 ASSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDYEQLFKSFER-----KQQQLDRMVPAKRS-- 532

  Fly   393 KKPKKETVTKEMSD-SLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERERVENSKLA 456
                    .|.::: :|.:.::|...:... |....:.:.:....|..:..|.::|.:    :|.
  Fly   533 --------NKNINNLTLNLQSVESQTQSPK-PSRKPAPAPRSIHLEQRQRRELIQRRK----QLK 584

  Fly   457 AKLAEL------EG-QLVRGGKNLLDTYSER-----------QIELEKKLVEIAERKKREIEIQQ 503
            .:||||      || :|..|.:.|..:.|.|           ::|.::....:.| :.::.:::|
  Fly   585 RELAELPPSAGIEGLELKLGEQPLAPSASPRLQLQALQNRVCRLEAQRNATRVME-ENQQAKLKQ 648

  Fly   504 QLELQEETTLEIR------ERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELE 562
            .:|::::...::|      ..|..|::|::|....|......:..|:.:..:.:|:|:
  Fly   649 SIEIKQDQLKKLRAMLKQKPNNACLKEELQLVCESLESDRKTFEDLEFQYFEEESEHH------- 706

  Fly   563 MAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKY---------DEEQEEWKFSSMSLPTPPGGD 618
             |.:|   |.|||            :|||..:|:.         |||:.       ..||.||..
  Fly   707 -ASHE---EFKRQ------------EQRLMLEAELAALRIQIGPDEEEP-------GSPTSPGST 748

  Fly   619 GK-----------FSSKRPVSHPQRRRPTSEYALQEAKSNSPSSLRFKSEN---IVNYELEMPCR 669
            |.           |.|...:. |:||.       ||       .|..||.|   ..|:::|  ..
  Fly   749 GSNLVNGVMSQSLFGSAELLC-PKRRN-------QE-------DLMSKSVNENMFYNHKIE--AN 796

  Fly   670 TTQEYRTP---------------KVSASLQAVLAQAMQTGGDDIDIVDSHTNSLRSRLEN----- 714
            |:...|.|               ..:.|||          ||..::     |.|..|:.:
  Fly   797 TSTPKRLPLQLFEDLAGGSCEQISFNLSLQ----------GDRFEV-----NPLERRVPSQDDID 846

  Fly   715 ----IINANANGGAGPGAGVAVGSSIPNV-RNIK 743
                :.| :|...|..||...:..||..: ||.|
  Fly   847 RSCKVAN-DAPISASQGASTKIFDSIMEIERNRK 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	50/275 (18%)
		KISc	20..351	CDD:214526	52/282 (18%)
		GBP_C	<479..576	CDD:303769	19/113 (17%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
CG5004	NP_573195.1	FHA	41..104	CDD:278899
		PH-like	1142..1242	CDD:302622
		PH	1143..1237	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930