DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif6

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_796026.2	Gene:	Kif6 / 319991	MGIID:	1098238	Length:	802	Species:	Mus musculus

Alignment Length:	861	Identity:	219/861 - (25%)
Similarity:	369/861 - (42%)	Gaps:	194/861 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ECVQVVVRCRP-----------MSNRERSERSPEVVNVYPNRGVVELQNVVDG---NKEQRKVFT 68
            :.:|:..|.:|           :...|:...|.|:  |.|       :::.||   ||.:...|.
Mouse     4 QTIQIFARVKPTVRKQQQGIYSIDEDEKLTHSLEI--VLP-------RDLADGFVNNKRESYKFK 59

  Fly    69 YDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTF 133
            :...:|..|.|..::..:..|:..|.|.|:||.||||||||:|||||:.|........||||||.
Mouse    60 FQRIFDQEAKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTL 124

  Fly   134 EQIWLHINRTENFQFLVDVSYLEIYMEELRDLLKP--NSKHLE-------VRERGSGVYVPNLHA 189
            ..|:..:.:..:..:...:||||||.|...|||.|  .:..||       :.:....:::.||..
Mouse   125 SYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLKNLSL 189

  Fly   190 INCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGS 254
            ....:.|:.:.::.:|:.||.:..|.||:.|:|||.||.:.:...:..:.|::..||:|:|||||
Mouse   190 HQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSATVRHAKLHLVDLAGS 254

  Fly   255 ERQSKTGASAERLKEASKINLALSSLGNVISALAES-SPHVPYRDSKLTRLLQDSLGGNSKTIMI 318
            ||.||||.....|.||..|||:|..|..||.||:|. ..|:|||:|.:|.:|:||||||..|.||
Mouse   255 ERVSKTGVGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIPYRNSMMTSVLRDSLGGNCMTTMI 319

  Fly   319 ANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNE--DPQDAKLKEYQEEIERLK-RLIGPQQQQR 380
            |.:.....|.:|:::|.|:|.|...|:|:.|.||  ||: ..:...|:|||.|| .|.....:||
Mouse   320 ATLSLEKRNIDESISTCRFAQRVALIKNEAILNEEIDPR-LMIVRLQKEIEDLKAELAMATGEQR 383

  Fly   381 SEKQVTAKKQRVKK----------PK-------------------------KETVTKEMSDSLQV 410
            :|....|:..:::|          |:                         |:|:...:|.....
Mouse   384 TEALTEAELLQLEKLIASYLEDQDPESRLEVGADMRKIHHCFHHFKKLLNDKKTLENTVSSESTR 448

  Fly   411 STIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERERVENSKLAAKLAELEGQLVRGGKNL-- 473
            ...::|:.|:...:.......::||..:..:..:.|:::.::   |.:.:.||....|..:|.
Mouse   449 QACQEPLRDEEYTKLLGLLKQRDNEINILVNMLKKEKKKTQD---ALQNSSLEKSDTRPPQNSPF 510

  Fly   474 ---------------------LDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRE 517
                                 |.....|...|.||           ..:::::.|..:...||.:
Mouse   511 IAGSPAVPRTPFSSAPSHTQDLSICRHRSSLLHKK-----------TGMREEMSLGRQEAFEIFK 564

  Fly   518 RNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLL-IIDN 581
            |:.:....:|..|:.|.:.:::..||.:.:|:.:|    .:.:|:.|.|:  :.|::..| |.:|
Mouse   565 RDHADSVTIEDNKQVLKQRFSEAKALGESINEARS----KIGQLKDAINQ--RHLQQVALGISEN 623

  Fly   582 FVPIEV--KQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQ-- 642
            .||...  .|....:|:.:||:..:|.:.|.|.         :.|..:.|.|.....::..||
Mouse   624 TVPASTPDPQEEKLRAQLEEEKGRYKTAFMHLK---------ALKVEIEHLQLLMDKAKVKLQKE 679

  Fly   643 -------EAKS---NSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDD 697
                   ||.|   |||::      |:.:.....|.:...:..:.|.|..|:      ::.|...
Mouse   680 FEAWWAEEATSLQVNSPAT------NLQDAVKPFPQQDQAQLLSKKSSRDLE------VENGAGR 732

  Fly   698 IDIVDSHTNSLRSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRGLPSAASNLDSNRRPP 762
            :::.|.                                  |.|.|     |||...|..|  :.|
Mouse   733 LEVCDR----------------------------------NARRI-----LPSPCPNQQS--QEP 756

  Fly   763 TGR--LPAKKPASAYP 776
            :|.  |...:|.|:.|
Mouse   757 SGSRVLVQDRPLSSIP 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	122/349 (35%)
		KISc	20..351	CDD:214526	125/354 (35%)
		GBP_C	<479..576	CDD:303769	19/96 (20%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
Kif6	NP_796026.2	KISc_KIF9_like	5..343	CDD:276826	122/346 (35%)
		Kinesin	11..345	CDD:278646	121/342 (35%)
		Cob_adeno_trans	<350..>408	CDD:294596	17/58 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810