DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Klp68D and Kif5a

DIOPT Version :10

Sequence 1:NP_524029.2 Gene:Klp68D / 39332 FlyBaseID:FBgn0004381 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_997688.1 Gene:Kif5a / 314906 RGDID:1303035 Length:1027 Species:Rattus norvegicus


Alignment Length:621 Identity:216/621 - (34%)
Similarity:330/621 - (53%) Gaps:73/621 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 SQTPNEC-VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDAS 76
            ::|.||| ::|:.|.||: |:....|..:.:.::.....|    ::.|     |.:.:|..:..:
  Rat     2 AETNNECSIKVLCRFRPL-NQAEILRGDKFIPIFQGDDSV----IIGG-----KPYVFDRVFPPN 56

  Fly    77 ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI- 140
            .||..:||.....:|..||.|:||.|||||||.:|||.||||...:.:|||||||....|:.|| 
  Rat    57 TTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIY 121

  Fly   141 NRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGV-YVPNLHAINCKSVEDMIKVMQV 204
            :..||.:|.:.|||.|||::::||||.....:|.|.|..:.| :|.........|.|:::.|:..
  Rat   122 SMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVRGCTERFVSSPEEILDVIDE 186

  Fly   205 GNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKE 269
            |..||.|..|||||||||||:||:|.|:..:.||.....|||.|.||||||:.|||||....|.|
  Rat   187 GKSNRHVAVTNMNEHSSRSHSIFLINIKQENIETEQKLSGKLYLADLAGSEKVSKTGAEGAVLDE 251

  Fly   270 ASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLT 333
            |..||.:||:|||||||||| :..:|||||||:||:||||||||.:|.|.....||:||..||.:
  Rat   252 AKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKS 316

  Fly   334 TLRYASRAKSIQNQPIKN-EDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAK--------K 389
            ||.:..|||:|:|....| |...:...|:|::|.|:.|          ::|:..||        :
  Rat   317 TLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTK----------AQKETIAKLEAELSRWR 371

  Fly   390 QRVKKPKKETVTKEMSDSLQVSTI--EQPVEDDSD------PEGAESESDKENEAEVAKSNEELE 446
            .....|:.|.:..|  ||...:.|  |.||.|:|.      ||  |.:..:|....:.|..::.:
  Rat   372 NGENVPETERLAGE--DSALAAEICEETPVNDNSSIVVRIAPE--ERQKYEEEIRRLYKQLDDKD 432

  Fly   447 RERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEI-AERKKREIEIQQQLELQEE 510
            .|..:.|:|..||.:   |::...:.|:.|..:.: :::::|..: :|....:.|:::.|:..||
  Rat   433 DEINQQSQLIEKLKQ---QMLDQEELLVSTRGDNE-KVQRELSHLQSENDAAKEEVKEVLQALEE 493

  Fly   511 TTLEIRERNVSLEQEVELKKR-------KLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNEL 568
            ..:...:::    ||||.|.:       :||:..|..|:|:.|....:.......:.:....|.|
  Rat   494 LAVNYDQKS----QEVEEKSQQNQLLVDELSQKVATMLSLESEPQRLQEVSGHQRKRIAEVLNGL 554

  Fly   569 VKELKRQLLIIDN---FVPIEVK---------QRLY 592
            :|:|....:|:.|   .:|:|:.         .|||
  Rat   555 MKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLY 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp68DNP_524029.2 KISc 20..351 CDD:214526 150/333 (45%)
Smc <431..>580 CDD:440809 32/156 (21%)
Kif5aNP_997688.1 KISc_KHC_KIF5 7..327 CDD:276820 150/329 (46%)
Microtubule-binding. /evidence=ECO:0000255 174..315 80/140 (57%)
Necessary for interaction with ZFYVE27. /evidence=ECO:0000250|UniProtKB:P33175 271..361 41/99 (41%)
Interaction with BICD2. /evidence=ECO:0000250|UniProtKB:Q12840 353..1027 56/260 (22%)
PRK03918 <409..920 CDD:235175 41/192 (21%)
Khc_CBD_cc 832..901 CDD:467880
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 906..936
Globular. /evidence=ECO:0000255 907..1027
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.