DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp68D and Kif12

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_006238315.1	Gene:	Kif12 / 313254	RGDID:	1308487	Length:	648	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	167/514 - (32%)
Similarity:	245/514 - (47%)	Gaps:	104/514 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKSRRPGTGSSQTPNECVQVVVRCRPMSNRE--RSERS------PEVVNVYPNRGVVELQNVVDG 59
            |::...|...|:||   :|||:|.||||..|  |.|:|      ...:.|.|..|..::
  Rat    12 ARNLEQGPEGSETP---IQVVLRVRPMSTVELRRGEQSALHCSGTRTLQVSPPGGGPDV------ 67

  Fly    60 NKEQRKVFTYDAAYDASATQTTLYHEV-VFPLVSSVLEGFNGCIFAYGQTGTGKTFTM------- 116
                  .|.:.|..|.:.||..::... |..|....|.||:..:|.:||||:|||:|:
  Rat    68 ------AFRFGAVLDGARTQEDVFRACGVKRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQA 126

  Fly   117 EGVRGNDELMGIIPRTFEQIWLHINRTENFQFLVDV--SYLEIYMEELRDLLKPNS-KHLEVR-E 177
            |||.....|.||:.|||  .|| ::|.::....|.:  ||||||.|:::|||...| :.|.|| .
  Rat   127 EGVPVPPSLAGIMQRTF--TWL-LDRMQHLDSPVTLRASYLEIYNEQVQDLLSQGSPRPLPVRWS 188

  Fly   178 RGSGVYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIK 242
            :..|.||..|..:.|.|:|.:::::|:|...|......:|:.||||||:..:.|.. .|......
  Rat   189 KARGFYVEQLRLVECGSLEALMELLQMGLSRRRSSSHTLNQASSRSHALLTLHISR-PTSQQVPP 252

  Fly   243 V--------GKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAE---SSPHVPY 296
            |        |||..:||||||:.:.||:..:.:.||:.||.:|.:||:.||.|.:   ...|:|:
  Rat   253 VDLGEPPVGGKLCFVDLAGSEKVAATGSRGQLMLEANSINRSLLALGHCISLLLDPQRKQSHIPF 317

  Fly   297 RDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQP-------IKNEDP 354
            ||||||:||.|||||...|:|:|.:.||.....|||:||||||||:.|..:|       :|....
  Rat   318 RDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRITTRPQGPKSPAVKPPQQ 382

  Fly   355 QDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVED 419
            .:|:|.:.||| .|..||        ...|:..|..||...:.....:.:...||...:|
  Rat   383 VEAELLQLQEE-NRCLRL--------QLDQMYTKAPRVHGARVAWAQRNLYGMLQEFMLE----- 433

  Fly   420 DSDPEGAESESDKENEAEVAKSNEELERE-----------RVENSKLAAKLAELEGQLV 467
                                  ||:|.:|           :.|...||.::.|||.:|:
  Rat   434 ----------------------NEKLRKEMRQLRSSRDLAQAEQHVLAQQIHELERRLL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	133/356 (37%)
		KISc	20..351	CDD:214526	135/368 (37%)
		GBP_C	<479..576	CDD:303769
		coiled coil	547..558	CDD:293879
Kif12	XP_006238315.1	KISc	25..363	CDD:276812	133/356 (37%)
		Kinesin	31..365	CDD:278646	130/349 (37%)
		Kinesin-relat_1	<384..469	CDD:289481	25/120 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810