Protein Alignment Klp68D and Klp3A

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Alignment Length: 829
• Identity: 227/829 - (27%)
• Similarity: 392/829 - (47%)
• Gaps: 164/829 - (19%)

  Fly    12 SSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGV-VELQNVVDGNKE----QRKVFTYDA 71
            ||:.|: ||.|.:|.||:...|.            :||. :.::...||..:    :.:.:||:.
  Fly     2 SSEDPS-CVAVALRVRPLVQSEL------------DRGCRIAVERSADGAPQVTVNRNESYTYNY 53

  Fly    72 AYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGN---DELMGIIPRTF 133
            .:|...:|..|:...|...|..:|.|:|..|.||||||:|||:|| |...|   |:.:|:|||..
  Fly    54 VFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVLDDHVGVIPRAV 117

  Fly   134 EQIWLHINRTEN-FQFLVDVSYLEIYMEELRDLLKPNSKH---LEVRERGSGVYVPNLHAINCKS 194
            ..|:..|...:: |:|.|..|::|:|.|:..||....::.   :::||..:.:.:|.|..:...|
  Fly   118 HDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTS 182

  Fly   195 VEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTE-TNTIKVGKLNLIDLAGSERQS 258
            .:.:...:..|:..|.|..|.|||.||||||||.:.:.....: ..::...:.||:|||||||.|
  Fly   183 AQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCS 247

  Fly   259 KTGASAERLKEASKINLALSSLGNVISAL--AESSPHVPYRDSKLTRLLQDSLGGNSKTIMIANI 321
            ||.||.:|.||...||..|.:|||||:||  .:::.::|||.|||||||||||||||.|:|||.:
  Fly   248 KTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACV 312

  Fly   322 GPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLK---------------- 370
            .|::||..|||:|||||.||..|:|:|:.|.||..|::...::.|::|:
  Fly   313 SPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISA 377

  Fly   371 -----------------RLIGPQQQQRSEKQVTAKKQRVKKPKKET---------------VTKE 403
                             .:....:.||.::||...:.|.:|.::|.               :.::
  Fly   378 VGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQ 442

  Fly   404 MSDSLQ--VSTIEQPVEDDSDPEGAESESDKENE------------AEVAKSNEELERERVENSK 454
            ..|.|:  ||.::..::.....:.....::.:||            .|:.::.||||.:..|:.:
  Fly   443 AHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQ 507

  Fly   455 LAAKLAELEGQLVRGGK--NLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRE 517
            ..:..:..||....|.:  .:|.::||   |...|.:..|...:   .|.:||:|::|....|.
  Fly   508 RLSSRSHTEGGESGGDEVHEMLHSHSE---EYTNKQMNFAGELR---NINRQLDLKQELHERIM- 565

  Fly   518 RNVSL----EQEVELK--KRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQL 576
            ||.|.    :::|:|:  .:|:....|:...|..:|.:.||   :|:      ..:|.:|.:::|
  Fly   566 RNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKS---KDI------SAKLAEERRKRL 621

  Fly   577 LIIDNFVPIEVKQRLYTQAKY----DEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTS 637
            .:::..:. :::::|.|||..    |:|:|  |..::|                         |.
  Fly   622 QLLEQEIS-DLRRKLITQANLLKIRDKERE--KIQNLS-------------------------TE 658

  Fly   638 EYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQ-EYRTPKVSASL---QAVLAQAMQTGGDDI 698
            ...::|:|.....::|.:||....:::......|| :.:..|:.:.:   |.:.::..|......
  Fly   659 IRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKC 723

  Fly   699 DIVDSHTNSLRSRLENIINANA-------NGGAGPGAGVAVGSSIPNVR 740
            :...:....|:..||...:|.|       |||:      |.|||..|.:
  Fly   724 EEALAANKRLKDALERQASAQAQRHKYKDNGGS------AAGSSNANAK 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	135/345 (39%)
		Smc	<431..>580	CDD:440809	38/168 (23%)
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	133/342 (39%)
		Smc	<453..>985	CDD:440809	71/364 (20%)
		Metallothio	<1071..1115	CDD:395080