Protein Alignment Klp68D and Kif13b

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001398965.1
• Gene: Kif13b / 305967
• RGDID: 1303307
• Length: 1843
• Species: Rattus norvegicus
• Alignment Length: 771
• Identity: 249/771 - (32%)
• Similarity: 379/771 - (49%)
• Gaps: 162/771 - (21%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGN------KEQRKVFTYDAAY---DA 75
            |:|.||.|||:.||....:..||:|..|:.::   |.::.|      :.|.|:|.||..:   |.
  Rat     6 VKVAVRVRPMNRREIDLHTKCVVDVEANKVIL---NPINTNLSKGDARGQPKIFAYDHCFWSMDE 67

  Fly    76 SATQTTLYHEVVFP-----LVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQ 135
            |..:.....:.||.     ::.:..:|:|.|||||||||:||::||   .|..:..|:|||....
  Rat    68 SVREKYAGQDDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTM---MGTADQPGLIPRLCSG 129

  Fly   136 IWLHINRTENFQ--FLVDVSYLEIYMEELRDLLKPNSKH--LEVRERG-SGVYVPNLHAINCKSV 195
            ::....:.||.:  |.|:|||:|||.|::||||.|....  |:|||.. .|.||..|..:...|.
  Rat   130 LFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSY 194

  Fly   196 EDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKI--EMCDTETNTI--KVGKLNLIDLAGSER 256
            :|:..:|..|||:|||..|||||.||||||:|.|.:  .:.|.::.|.  |||||:|:|||||||
  Rat   195 KDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSER 259

  Fly   257 QSKTGASAERLKEASKINLALSSLGNVISALAE------SSPHVPYRDSKLTRLLQDSLGGNSKT 315
            .:||||:.:||||.|.||.:|::||.||||||:      .:..||||||.||.||:|||||||||
  Rat   260 ATKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGNSKT 324

  Fly   316 IMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLI------- 373
            .|:|.:.|:..||:|||:|||||.|||.|.|..:.||||....:::.:||:|:|:..:
  Rat   325 AMVATVSPAADNYDETLSTLRYADRAKHIINHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMK 389

  Fly   374 GPQQQQR---SEK---QVTAKKQRVKKPKKETVTKE-------MSDSLQVSTIEQPVEDD----- 420
            .|:.:.|   |||   ::|...:. |..|.|.:.:|       :..|||.|.|:  |.||
  Rat   390 SPELKDRLEESEKLIQEMTVTWEE-KLRKTEEIAQERQKQLESLGISLQTSGIK--VGDDKCFLV 451

  Fly   421 ---SDPE---------------GAESESDKE----------------NEAEVAKSNEELERERVE 451
               :||.               |:.:..|.:                .|.:|..:.::..|..|.
  Rat   452 NLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHGIIDIMPEGQVMLTPQKNTRTFVN 516

  Fly   452 NSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQ-----QQLELQEET 511
            .|.:::.:....|..:..|.|   .:....:..:||..| .|.::||..::     :||:...::
  Rat   517 GSSVSSPIQLHHGDRILWGNN---HFFRLNLPKKKKKAE-REDEEREASLKNDSSSEQLDADGDS 577

  Fly   512 TLEI-RERNVSLE---QEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKEL 572
            :.|: .|.|.:.|   .||.:      |.......:|..|:..:..|.::.|          ..|
  Rat   578 SSEVSSEINFNFEYAQMEVTM------KALGSNDPMQSILSSLEQQHEEEKR----------SAL 626

  Fly   573 KRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTS 637
            :||.|:.::    |::|   .:.:...|::..:           |..:.|...| |..||.|..:
  Rat   627 ERQRLMYEH----ELEQ---LRRRLSPERQNCR-----------GVDRLSFHSP-SAQQRLRQWA 672

  Fly   638 EYALQEAKSNSPSSLRFKSENIVNYEL----------EMPCRTTQEYR-TPKVSAS 682
            |    |.::...:||....|.||...|          |:..||  ||: |.::.||
  Rat   673 E----EREATLNNSLMRLREQIVKANLLVREASYIAEELDKRT--EYKVTLQIPAS 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	162/359 (45%)
		Smc	<431..>580	CDD:440809	32/173 (18%)
Kif13b	NP_001398965.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	162/359 (45%)
		Kinesin_assoc	357..469	CDD:465047	28/114 (25%)
		FHA_KIF13B	447..545	CDD:438782	12/100 (12%)
		COG4913	<614..>760	CDD:443941	32/144 (22%)
		KIF1B	756..802	CDD:463574
		C2-C2_1	<888..>952	CDD:463310
		bMERB_dom	<1073..1143	CDD:463467
		DUF3694	<1214..1277	CDD:463599
		PHA03247	<1377..1715	CDD:223021
		CAP_GLY	1720..1783	CDD:460154