DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif26b

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_038946745.1	Gene:	Kif26b / 305012	RGDID:	1560022	Length:	2138	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	189/800 - (23%)
Similarity:	299/800 - (37%)	Gaps:	210/800 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PGTGSSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVEL--------QNVVDGNKEQ- 63
            ||.|.       |:|::|....|.|:.|| |...:.|.|.:..:.|        .|.......|
  Rat   466 PGMGK-------VKVMLRICSASARDTSE-SSSFLKVDPRKKQITLYDPLTCGGHNAFQKRSSQV 522

  Fly    64 -RKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMG 127
             .|:|.:||.:...|:|..:....|..::.||:.|.:||:|.:|....||::||.|...:.:.:|
  Rat   523 PPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGRDDSMQNLG 587

  Fly   128 IIPRTFEQIWLHINRTE---NFQFLVDVSYLEIY--MEELRDLLKPNSKHLEVRERGSGVY---- 183
            |||.....::..||..:   ..:|.|.:|.:|::  .|.|||||...:.......:..|||
  Rat   588 IIPCAISWLFKLINERKEKTGARFSVRISAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCED 652

  Fly   184 ------VPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSR-SHAIFMIKIEMCDTETNTI 241
                  :.|...:...:.|.....:.....:|.....:.:|...| ||.:|.:.|.....|
  Rat   653 PICGTQLQNQSELRAPTAEKAAFFLDAAIASRRSNQQDCDEDDHRNSHMLFTLHIYQYRME---- 713

  Fly   242 KVGK---------LNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESSPHVPYR 297
            |.||         |:||||.     |...|.::..:..|.:.|:||:|||||.||...|.|:||:
  Rat   714 KSGKGGMSGGRSRLHLIDLG-----SCVKALSKNREGGSGLCLSLSALGNVILALVNGSKHIPYK 773

  Fly   298 DSKLTRLLQDSLGG-NSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKE 361
            :||||.||::|||. |.:|.|||:|..:..:|.|||:|::.|||
  Rat   774 ESKLTMLLRESLGNVNCRTTMIAHISAAAGSYAETLSTIQIASR--------------------- 817

  Fly   362 YQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDD------ 420
                :.|:|:.........|..:.:.::.|:::|.:          |:......||:.:
  Rat   818 ----VLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQ----------LRPFHARAPVDPEFPLAPL 868

  Fly   421 -SDPE-GAESESDKENEAEVAKSNEEL-ERERVENSKLAAKLAELEG-----------QLVRGGK 471
             |||: .:.||...:....:..:...| ::|..:|          ||           |..||
  Rat   869 SSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDN----------EGPPDFVPIVPALQKTRG-- 921

  Fly   472 NLLDTYSERQIELEKKLVEIAERK----KREIEIQQQLEL----QEETTLEIRERNVSLEQEVEL 528
                  ..|..|..:.....:||.    ....|:|::|:.    :|.......|..|....|...
  Rat   922 ------DSRPGEAAESAASKSERDCLKCNTFAELQERLDCIDGSEEPNRFPFEELPVQFGPEQAG 980

  Fly   529 KKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYT 593
            :...||:........:.:..|..||:.| |.|.|.::           |......||.......|
  Rat   981 RCTSLSQAAGPDTLSESDKEDNGSDNGQ-LTEREGSE-----------LPTSKVQPIRSPGPTVT 1033

  Fly   594 QAKYDEEQEEWKFSSMSLPTP---PGGDGKFSSKRPVSHPQ----------------RRRP---- 635
            .:           ||.|..:|   ||...:.|:.:....|.                :.||
  Rat  1034 GS-----------SSPSPASPRSIPGSSSQHSTSQLTQSPSLQSSRESLDSCGFVEGKPRPMGSP 1087

  Fly   636 ---------TSEY-----ALQEAK----------SNSPSSLRFKSENIVNYELEMPCRTTQEYRT 676
                     ||||     ..|..|          |..|.||...|..:.:..|..|     :.||
  Rat  1088 RLGIASLSKTSEYKPPSSPSQRCKVYTQKGVLPSSAPPPSLSKDSGMVSSESLLQP-----DVRT 1147

  Fly   677 PKVSASLQAVLAQAMQTGGD 696
            |.|..|.| |:.::|..|.:
  Rat  1148 PPVGMSPQ-VVKKSMSAGSE 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	109/361 (30%)
		KISc	20..351	CDD:214526	109/366 (30%)
		GBP_C	<479..576	CDD:303769	20/104 (19%)
		coiled coil	547..558	CDD:293879	4/10 (40%)
Kif26b	XP_038946745.1	KISc	470..818	CDD:276812	109/389 (28%)
Kif26b	XP_038946745.1	PHA03307	1721..>2012	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900