DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif3b

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001099999.1	Gene:	Kif3b / 296284	RGDID:	1306815	Length:	747	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	360/791 - (45%)
Similarity:	506/791 - (63%)	Gaps:	73/791 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTT 81
            :|.|:||||||||:.:|::....:||:|....|.|.::|....:.|..|.||:||.||.:|.|..
  Rat     7 SESVRVVVRCRPMNGKEKAAAYDKVVDVDVKLGQVSVKNPKGTSHEMPKTFTFDAVYDWNAKQFE 71

  Fly    82 LYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTENF 146
            ||.|...|||.|||:||||.||||||||||||:|||||||:.|..|:||.:|:.|:.||:|::|.
  Rat    72 LYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPEKRGVIPNSFDHIFTHISRSQNQ 136

  Fly   147 QFLVDVSYLEIYMEELRDLL-KPNSKHLEVRER-GSGVYVPNLHAINCKSVEDMIKVMQVGNKNR 209
            |:||..||||||.||:|||| |..:|.||::|| .:||||.:|.:...|||:::..||.|||:||
  Rat   137 QYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNR 201

  Fly   210 TVGFTNMNEHSSRSHAIFMIKIEMCDT---ETNTIKVGKLNLIDLAGSERQSKTGASAERLKEAS 271
            :||.||||||||||||||:|.:|..:.   ..|.|:||||||:||||||||:||||..||||||:
  Rat   202 SVGATNMNEHSSRSHAIFVITVECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEAT 266

  Fly   272 KINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTL 335
            ||||:||:||||||||.: .|.|:||||||||||||||||||:||:|:||:||::||..||||||
  Rat   267 KINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTL 331

  Fly   336 RYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERL-----KRLIGPQQQQR------------SEK 383
            |||:|||:|:|:|..||||:||.|:|:||||.||     ||.||.::::.            .|:
  Rat   332 RYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEE 396

  Fly   384 QVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERE 448
            :...::...:...|:...:|..:.|::.. ...|||.|.....:....||.|    |..|:|.||
  Rat   397 EEEGEEGEEEGDDKDDYWREQQEKLEIEK-RAIVEDHSLVAEEKMRLLKEKE----KKMEDLRRE 456

  Fly   449 RVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTL 513
            :.....|.||:..:|.:|:.||||::|..:|:|..||:|..||||:|:||.|||||:|.::|.||
  Rat   457 KDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETL 521

  Fly   514 EIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLI 578
            |::|...||:|||::|.:||.|.::|..|::.|::|.:.:|.::.:|||..||||.:|||.:.||
  Rat   522 ELKETYTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLI 586

  Fly   579 IDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQE 643
            |:||:|:|.|.::..::.:|:|::.||...::..     :.:...|||||....:||.|::|...
  Rat   587 IENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRL-----ENQQMMKRPVSAVGYKRPLSQHARMS 646

  Fly   644 AKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIVDSHTNSL 708
            .......  |:::|||:..||:||.|||::|..|.:|..:||.|..|:|    |.|.:....:|.
  Rat   647 MMIRPEP--RYRAENIMLLELDMPSRTTRDYEGPAISPKVQAALDAALQ----DEDEIQVDASSF 705

  Fly   709 RSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRGLPSAASNLDSNRRPPTGRLPAKKPAS 773
            .|      .||....|.|.:|...|:|       .||.|.|:                     :.
  Rat   706 ES------TANRKAKARPKSGRKSGAS-------SSSSGNPA---------------------SQ 736

  Fly   774 AYPKARGLVNK 784
            .||::||||.|
  Rat   737 FYPQSRGLVPK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	204/331 (62%)
		KISc	20..351	CDD:214526	206/336 (61%)
		GBP_C	<479..576	CDD:303769	47/96 (49%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
Kif3b	NP_001099999.1	KISc_KIF3	8..340	CDD:276822	204/331 (62%)
Kif3b	NP_001099999.1	Smc	<352..>614	CDD:224117	98/266 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340626
Domainoid	1	1.000	225	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55849
Inparanoid	1	1.050	610	1.000	Inparanoid score	I884
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0002745
OrthoInspector	1	1.000	-	-		oto96739
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1829
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760