DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif26b

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001155137.1	Gene:	Kif26b / 269152	MGIID:	2447076	Length:	2112	Species:	Mus musculus

Alignment Length:	803	Identity:	190/803 - (23%)
Similarity:	301/803 - (37%)	Gaps:	216/803 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PGTGSSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVEL--------QNVVDGNKEQ- 63
            ||.|.       |:|::|....|.|:.|| |...:.|.|.:..:.|        ||.......|
Mouse   446 PGMGK-------VKVMLRICSTSARDTSE-SSSFLKVDPRKKQITLYDPLTCGGQNAFQKRSSQV 502

  Fly    64 -RKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMG 127
             .|:|.:||.:...|:|..:....|..::.||:.|.:||:|.:|....||::||.|...:.:.:|
Mouse   503 PPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGRDDSMQNLG 567

  Fly   128 IIPRTFEQIWLHINRTE---NFQFLVDVSYLEIY--MEELRDLLKPNSKHLEVRERGSGVY---- 183
            |||.....::..||..:   ..:|.|.:|.:|::  .|.|||||...:.......:..|||
Mouse   568 IIPCAISWLFKLINERKEKTGARFSVRISAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCED 632

  Fly   184 ------VPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSR-SHAIFMIKIEMCDTETNTI 241
                  :.|...:...:.|.....:.....:|.....:.:|...| ||.:|.:.|.....|
Mouse   633 PICGTQLQNQSELRAPTAEKAAFFLDAAIASRRSNQQDCDEDDHRNSHMLFTLHIYQYRME---- 693

  Fly   242 KVGK---------LNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESSPHVPYR 297
            |.||         |:||||.     |...|.::..:..|.:.|:||:|||||.||...|.|:||:
Mouse   694 KSGKGGMSGGRSRLHLIDLG-----SCVKALSKNREGGSGLCLSLSALGNVILALVNGSKHIPYK 753

  Fly   298 DSKLTRLLQDSLGG-NSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKE 361
            :||||.||::|||. |.:|.|||:|..:..:|.|||:|::.|||
Mouse   754 ESKLTMLLRESLGNVNCRTTMIAHISAAASSYAETLSTIQIASR--------------------- 797

  Fly   362 YQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDD------ 420
                :.|:|:.........|..:.:.::.|:::|.:          |:......||:.:
Mouse   798 ----VLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQ----------LRPFHARAPVDPEFPLAPL 848

  Fly   421 -SDPE-GAESESDKENEAEVAKSNEEL-ERERVENSKLAAKLAELEG-----------QLVRGGK 471
             |||: .:.||...:....:..:...| ::|..:|          ||           |..||
Mouse   849 SSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDN----------EGPPDFVPIVPALQKTRG-- 901

  Fly   472 NLLDTYSERQIELEKKLVEIAERK----KREIEIQQQLEL----QEETTLEIRERNVSLEQEVEL 528
                  ..|..|..:.....:||.    ....|:|::|:.    :|.:.....|..:....|...
Mouse   902 ------DSRPGEAAEAAASKSERDCLKCNTFAELQERLDCIDGSEEPSKFPFEELPIQFGPEQAG 960

  Fly   529 KKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYT 593
            :...||:........:.|..|..||:.| |.|.|..:                 :|....||..:
Mouse   961 RCAPLSQAVGPDTPSESEKEDNGSDNGQ-LTEREGTE-----------------LPASKAQRNRS 1007

  Fly   594 QAKYDEEQEEWKFSSMSLPTP------PGGDGKFSSKRPVSHPQ----------------RRRP- 635
            .|.        ..:..|.|:|      ||...:.|:.:....|.                :.||
Mouse  1008 PAP--------TVTRSSSPSPASPRSIPGSSSQHSTSQLTQSPSLQSSRESLNSCGFVEGKPRPM 1064

  Fly   636 ------------TSEY-----ALQEAK----------SNSPSSLRFKSENIVNYELEMPCRTTQE 673
                        ||||     ..|..|          |..|.||...|..:.:..|..|     :
Mouse  1065 GSPRLGIASLSKTSEYKPPSSPSQRCKVYTQKGVLPSSAPPPSLSKDSGMVSSESLLQP-----D 1124

  Fly   674 YRTPKVSASLQAVLAQAMQTGGD 696
            .|||.|..|.| ||.::|..|.:
Mouse  1125 VRTPPVGMSPQ-VLKKSMSAGSE 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	110/361 (30%)
		KISc	20..351	CDD:214526	110/366 (30%)
		GBP_C	<479..576	CDD:303769	20/104 (19%)
		coiled coil	547..558	CDD:293879	4/10 (40%)
Kif26b	NP_001155137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..286
		KISc	450..798	CDD:276812	110/389 (28%)
		KISc	451..798	CDD:214526	110/381 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..859		9/63 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..917		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	955..1165		47/224 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1405..1501
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1569..1649
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1687..1734
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1748..1801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1816..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1899..1971
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900