DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and klp3

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_594686.1	Gene:	klp3 / 2542195	PomBaseID:	SPAC1834.07	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	580	Identity:	188/580 - (32%)
Similarity:	285/580 - (49%)	Gaps:	75/580 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYP-NRGVVELQ-NVVDGNKEQRKVFTYDAAYDASATQTTL 82
            ::||.|.||.:..|:......|  :|| |...|.:: :...||      |.:|..:..|:||..:
pombe     4 IKVVCRIRPTNQLEQDLGGNNV--IYPLNDSTVHIETSDYSGN------FVFDRVFHPSSTQNDI 60

  Fly    83 YHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI-NRTENF 146
            :...:...|..:..|:||.:.||||||:|||:||.|:..|.|..|:.||...:|:..| :.....
pombe    61 FSYSIESTVDDLFLGYNGTVLAYGQTGSGKTYTMMGIENNFEKEGMTPRMLRRIFDKIRDSPSTT 125

  Fly   147 QFLVDVSYLEIYMEELRDLLKPNSKHLEVRE-RGSGVYVPNLHAINCKSVEDMIKVMQVGNKNRT 210
            ::.|.|||:|||||::.|||...:..|.|.| :..||||..|..|...|..:.:.::..|..:|.
pombe   126 EYEVKVSYMEIYMEKIHDLLSEKNDRLTVHEDKLQGVYVQGLKTIYVSSETEALDILNKGMGSRA 190

  Fly   211 VGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEASKINL 275
            |..|:||..|||||:||::::...|||:...:.|:|.|:||||||...|:||..:.|:||.|||.
pombe   191 VASTSMNAQSSRSHSIFVLEVVQTDTESGETRRGRLFLVDLAGSESVGKSGAVGQTLEEAKKINR 255

  Fly   276 ALSSLGNVISALAESS-PHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYAS 339
            :||:||.||::|.:|. .|||||||||||:|::||||||:|.:|.|..|.:||..|||:|||:..
pombe   256 SLSTLGMVINSLTDSKLSHVPYRDSKLTRILKESLGGNSRTTLIINCSPDSYNATETLSTLRFGH 320

  Fly   340 RAKSIQNQPIKNE----DPQDAKLKEYQEEIERLKRLIGPQQQQR------------SEKQVTAK 388
            |||||:|:.:.|.    |....:|..|::.:.|.  :.|.:....            .|..:|..
pombe   321 RAKSIKNKAVVNSELSVDEMKRQLYIYKDALSRC--VCGARINNNLDYNNCHSNVWSGEHSLTLS 383

  Fly   389 KQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAES------ESDKENEAEVAKSNEELER 447
            ....|...||      ::.:|.:...|...:|.|.....|      :||..|.. .|::..||::
pombe   384 NLAEKSNLKE------AEIIQGNRTIQESNNDRDESTVASIHRHNFDSDSINRL-YAEAQLELKQ 441

  Fly   448 ERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETT 512
            .....|....:|::|        ...|....||.:||.|.     .|....:.....|..:...|
pombe   442 RDGVLSSTKQQLSDL--------MTALGDAQERYVELVKN-----HRVNSNLTANNSLNDKPGFT 493

  Fly   513 LEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKEL 572
            :|.:::|.|:..|.....:|||..                  :..|..|...|.:|:|.|
pombe   494 IEQKDKNFSINNERNNFLQKLSTL------------------DSSLAALVNVQRKLIKAL 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	138/328 (42%)
		KISc	20..351	CDD:214526	141/335 (42%)
		GBP_C	<479..576	CDD:303769	21/94 (22%)
		coiled coil	547..558	CDD:293879	0/10 (0%)
klp3	NP_594686.1	KIP1	1..546	CDD:227392	188/580 (32%)
klp3	NP_594686.1	KISc_KHC_KIF5	1..325	CDD:276820	138/328 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I786
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960