Protein Alignment Klp68D and KIF6

DIOPT Version :9

• Sequence 1: NP_001261726.1
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_005248961.1
• Gene: KIF6 / 221458
• HGNCID: 21202
• Length: 842
• Species: Homo sapiens
• Alignment Length: 857
• Identity: 215/857 - (25%)
• Similarity: 386/857 - (45%)
• Gaps: 174/857 - (20%)

  Fly    18 ECVQVVVRCRP--MSNRERSERSPEVVNVYPNRGVVELQNVVDG---NKEQRKVFTYDAAYDASA 77
            :.:|:..|.:|  ..:::......|...:.|:..::..:::.||   ||.:...|.:...:|..|
Human     4 QTIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQDA 68

  Fly    78 TQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINR 142
            .|.|::..:..|:..|||.|:||.||||||||:|||||:.|........||||||...|:..:.:
Human    69 NQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQK 133

  Fly   143 TENFQFLVDVSYLEIYMEELRDLLKP--NSKHLE-------VRERGSGVYVPNLHAINCKSVEDM 198
            ..:..:...:||||||.|...|||.|  .:..||       :.:....:::.||......:.|:.
Human   134 DSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLKNLTLHQATTEEEA 198

  Fly   199 IKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGAS 263
            :.::.:|:.||.:..|.||:.|:|||.||.|.:...:..:.|::..||:|:|||||||.:|||..
Human   199 LNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVG 263

  Fly   264 AERLKEASKINLALSSLGNVISALAES-SPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYN 327
            ...|.||..|||:|..|..||.||:|. ..|:|||:|.:|.:|:||||||..|.|||.:.....|
Human   264 GHLLTEAKYINLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRN 328

  Fly   328 YNETLTTLRYASRAKSIQNQPIKNED--PQDAKLKEYQEEIERLK-RLIGPQQQQRSEKQVTAKK 389
            .:|:::|.|:|.|...|:|:.:.||:  |: ..:|..|:||:.|| .|.....:||:|....|:.
Human   329 LDESISTCRFAQRVALIKNEAVLNEEINPR-LVIKRLQKEIQELKDELAMVTGEQRTEALTEAEL 392

  Fly   390 QRVKKPKKETVTKEMSDS---------------------------LQVSTIEQPVEDDSDPEGAE 427
            .:::|.....:..:.|||                           |:.:|:....:|....|..:
Human   393 LQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENNTVSSESKDQDCQEPLK 457

  Fly   428 SE---------SDKENEAEVAKSNEELERERVENSKLAAKLAEL-------------------EG 464
            .|         ..::||..:..:..:.|:::.:.   |..||.:                   ||
Human   458 EEEYRKLRDILKQRDNEINILVNMLKKEKKKAQE---ALHLAGMDRREFRQSQSPPFRLGNPEEG 519

  Fly   465 QLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTL------EIRER----N 519
            |.:|    |....|:.|        :.:...||...:.:::.::||.:|      ||.:|    :
Human   520 QRMR----LSSAPSQAQ--------DFSILGKRSSLLHKKIGMREEMSLGCQEAFEIFKRDHADS 572

  Fly   520 VSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLIIDN--- 581
            |:::...::.|::.|:  ||  ||.:.:|:.:|.... |:| |:.|..:.:.   .|.|.:|
Human   573 VTIDDNKQILKQRFSE--AK--ALGESINEARSKIGH-LKE-EITQRHIQQV---ALGISENMAV 628

  Fly   582 -FVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQEAK 645
             .:|.:.:::|.:|.:.::.:.:..|:.:.           :.|..:.|.|.....::..||:
Human   629 PLMPDQQEEKLRSQLEEEKRRYKTMFTRLK-----------ALKVEIEHLQLLMDKAKVKLQK-- 680

  Fly   646 SNSPSSLRFK---SENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIVDSHTNS 707
                   .|:   :|...|.::..|...:.::..|.:..|                   ||
Human   681 -------EFEVWWAEEATNLQVNSPAVNSLDHTKPFLQTS-------------------DS---- 715

  Fly   708 LRSRLENIINANANGG---AGPGAGVAVGSSIPNVRNIKSSRGLPSAASNLDSNRRPPTG----- 764
             :.....:::..::||   ...|.|..      :|.::.:.:.|||...:..|.::..|.
Human   716 -QHEWSQLLSNKSSGGWEVQDQGTGRF------DVCDVNARKILPSPCPSPHSQKQSSTSTPLED 773

  Fly   765 RLPAKKPASAYP 776
            .:| |:|.|:.|
Human   774 SIP-KRPVSSIP 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	121/340 (36%)
		KISc	20..351	CDD:214526	123/345 (36%)
		GBP_C	<479..576	CDD:303769	22/106 (21%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:277568	121/337 (36%)
		Kinesin	11..345	CDD:278646	120/333 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810