Protein Alignment Klp68D and klp-4

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001359864.1
• Gene: klp-4 / 180608
• WormBaseID: WBGene00002217
• Length: 1576
• Species: Caenorhabditis elegans
• Alignment Length: 978
• Identity: 275/978 - (28%)
• Similarity: 418/978 - (42%)
• Gaps: 302/978 - (30%)

  Fly    16 PNE--CVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYD-------- 70
            |:|  .|:|.:|.||.:.||...::..||.:...:.|  |.:.::  ::..|.||:|
 Worm     4 PDEESAVKVAIRVRPFNKRELDLKTKSVVRIQKEQCV--LHHPIE--EKNSKTFTFDHSFCSTDP 64

  Fly    71 AAYDASATQTTLYHEVVFPLVSSVLE----GFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPR 131
            .:||.::.:|..||     |.|.|:|    |:|.|||||||||:||::||   .|..:..|||||
 Worm    65 HSYDFASQETVSYH-----LGSGVVENAFSGYNACIFAYGQTGSGKSYTM---MGTPDQPGIIPR 121

  Fly   132 TFEQIWLHINRTEN--FQFLVDVSYLEIYMEELRDLLKP--NSKHLEVRE-RGSGVYVPNLHAIN 191
            ....|:..|..|.|  ..|.|:|||:|||.|.:||||.|  :||.|:||| :..|..|..|..:.
 Worm   122 VCNDIFTRIQETSNSSLSFKVEVSYMEIYNERVRDLLDPKKSSKALKVREHKILGPMVDGLSILA 186

  Fly   192 CKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTI----------KVGKL 246
            ..|.|.:..:::.|||:|||..||||..||||||:|.:.:      |.|:          ||.|:
 Worm   187 VNSFEQISNLLEEGNKSRTVAATNMNAESSRSHAVFSLIV------TQTLHDLENGFSGEKVAKI 245

  Fly   247 NLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAE----SSPHVPYRDSKLTRLLQD 307
            :|:|||||||..||||..:||:|...||.:|::||.|||||||    ....:|||||.||.||:|
 Worm   246 SLVDLAGSERAGKTGAVGKRLEEGGNINKSLTTLGMVISALAERNSKKDKFIPYRDSVLTWLLKD 310

  Fly   308 SLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRL 372
            ||||||:|:|||.:.|:..||.|||:|||||.|||.|.|..|.||||....::|.:||:|.|:..
 Worm   311 SLGGNSRTVMIATLSPAADNYEETLSTLRYADRAKKIVNHAIINEDPNARVIRELREEVETLRMQ 375

  Fly   373 IGPQQQQRSE----KQVTAKKQRV--------KKPKKETVT------KEMSD---SLQVSTIEQP 416
            |...:::.:|    ::..|:.:|:        ::..|||.|      |::::   |::.|.|:
 Worm   376 ITQTKKEHAETEELRERLAESERLVAQMNKSWEERLKETDTLNKERQKDLTEIGISIESSGIK-- 438

  Fly   417 VEDD--------SDPEGAESESDKENEAEVAKSNEELERERVENSKLAAKLAELE---------- 463
            ||.|        :||...|......|.:.:..::||||..|  :|.|:...::..
 Worm   439 VEKDRFYLVNMNADPSLNELLVYYINGSAIIGNSEELETSR--DSGLSMTCSDSSRRDDDKERTS 501

  Fly   464 ------GQLVRGGKNLLDTY------------SERQIELEKKLVEIAERK--------------- 495
                  |.:.|..|..::.|            ||.:|.:..|  :|.||.
 Worm   502 IVLRGLGIMRRHAKMTVEEYGGRLRLFVAPMSSECRICVNGK--QITERTLLRNGNRLLVGMNHF 564

  Fly   496 -----KREIEIQQQL---------------------------ELQEETTLEIRE-RNVSLEQEVE 527
                 .:.::::|.:                           :..|..||:.:| :..:|||:.|
 Worm   565 FKVNCPKVMDMEQSIMEDSTMFDYNDAWHEVNDANPISSAVDQYMESVTLKHQEDKKAALEQQYE 629

  Fly   528 L--------------------------------------------KKRKLSKCYAKYLALQQE-- 546
            .                                            |:...||.:  |.|.::|
 Worm   630 AFEKYIQSLTAGGFTPSTPMTPGFCLPTPITTPTGLPPFPFPANPKQSVKSKFF--YWAQRKEEM 692

  Fly   547 ----LNDCKSD--H-NQDLRELEMAQNELVKELKRQL-------LIIDNFVPIEVK--------- 588
                |...|:|  | |..:||..|...||.|:.|||.       :...|..||::|
 Worm   693 FAESLKRLKADVIHANALVREANMISKELNKKPKRQTTYDVTLQIPASNLRPIKIKAGQFVCEPV 757

  Fly   589 ----------QRLYTQAK-----------YDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQR 632
                      .:.:|.::           |::....:..:|.||...|             |
 Worm   758 IVVRREGMSGSQFWTVSQLESRLVDMRDTYNDMLNGFTRTSESLNGTP-------------H--- 806

  Fly   633 RRPTSEYALQEAKSNSPSSL----RFKSE------NIVNYELEMPCRTTQ-EYRTPKVSASLQAV 686
               .|...:.....|..|||    .|:|:      .:.|..||:.....: :|:.|        :
 Worm   807 ---ASPMKIAGIPMNECSSLVIDPFFESQEHHNLVGVANVFLEVLFHDLRLDYQVP--------I 860

  Fly   687 LAQAMQTGGDDIDIVDSHTNSLRSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRGLPSA 751
            ::|..:..|      ..|....|...:..::..:|.    |....:|.:|.....||.:.|||..
 Worm   861 ISQQGEVAG------RLHVQIFRVVTQEEMDETSNN----GPETLLGKTITCRVRIKRASGLPEK 915

  Fly   752 ASN 754
            .||
 Worm   916 LSN 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	160/361 (44%)
		Smc	<431..>580	CDD:440809	48/284 (17%)
klp-4	NP_001359864.1	KISc_KIF1A_KIF1B	10..354	CDD:276816	160/361 (44%)
		Kinesin_assoc	351..463	CDD:465047	28/113 (25%)
		FHA_KIF13	443..570	CDD:438758	22/130 (17%)
		KIF1B	776..840	CDD:463574	13/82 (16%)
		DUF3694	<1239..1293	CDD:463599