Protein Alignment Klp68D and klp-12

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001023349.1
• Gene: klp-12 / 178057
• WormBaseID: WBGene00002223
• Length: 1605
• Species: Caenorhabditis elegans
• Alignment Length: 846
• Identity: 245/846 - (28%)
• Similarity: 384/846 - (45%)
• Gaps: 174/846 - (20%)

  Fly    19 CVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLY 83
            ||||.:|.||..|||:.|.|....:|.||    :.|..:.|::.    ||||..:|....|..:|
 Worm     5 CVQVALRIRPQGNREKLEGSRVCTSVLPN----DPQVTIGGDRS----FTYDHVFDMPTLQYVVY 61

  Fly    84 HEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTM-----EGVRGNDELMGIIPRTFEQIWLHINRT 143
            ...|..||..:.:|:|..:.||||||:|||.||     ..|...:|.:|:|||..:..:..|...
 Worm    62 ESCVEKLVDGLFDGYNATVLAYGQTGSGKTHTMGTAFDAAVTQKEEDLGVIPRAIQHTFRKIAEC 126

  Fly   144 E---------NFQFLVDVSYLEIYMEELRDLLKPN---SKHLEVRERGSGVYVPNLHAINCKSVE 196
            :         ...|.|.|.::|:|.:::.|||..:   |..:.:.|...|..|  ||.:..:||.
 Worm   127 KAQAIEQGLLEPAFEVSVQFVELYNDDVLDLLSDDRSMSSSIRIHEDSRGEIV--LHGVEQRSVF 189

  Fly   197 DM---IKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTI------KVGKLNL---- 248
            ||   :.:::.|..||||..|||||.||||||||.:.::......|.:      |.|:|.:
 Worm   190 DMHGTMDILKNGALNRTVAATNMNEQSSRSHAIFTLHLKQQRVAANPLDESGEQKTGELEMEMLC 254

  Fly   249 -----IDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESS---PHVPYRDSKLTRLL 305
                 :|||||||..:|||:.:|.||...||:.|.:|||||:||..::   .|||||||||||||
 Worm   255 AKFHFVDLAGSERMKRTGATGDRAKEGISINVGLLALGNVIAALGGANGKVSHVPYRDSKLTRLL 319

  Fly   306 QDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLK 370
            ||||||||:|:|||...||:.::.|||.|::||:|||.|:|:.:.|:|.....:.|.:..|..|:
 Worm   320 QDSLGGNSRTLMIACCSPSDSDFVETLNTMKYANRAKEIKNKVVANQDKSSKMIGELRSRIAALE 384

  Fly   371 -RLIGPQQQQRS-------------------EKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQ 415
             .|:..:|.:|:                   ..:|...:.|||      ...|..|.|:...|:.
 Worm   385 AELLEFKQGRRTVDVDGHEVVNDQYHENVYLTSEVNHLRFRVK------ALNETLDILRTENIDL 443

  Fly   416 PVEDD---------SDPEGAESESDKENEAEVAKSNEELERE--------------RVENSKLAA 457
            ..:.:         :...|||.|.| ..::...|..|||||.              |.:|::..|
 Worm   444 KAKQEFNSIASLPTAGSGGAEGEVD-AIQSTFRKYLEELERTKSLLYESQSTCDQLRKDNARWKA 507

  Fly   458 -----------------KLAELEGQLVR-----------GGKNLLDTYSER-------------- 480
                             ||.|:..|.|.           ||:|:...||..
 Worm   508 LGASRGSGGGNAEFNSQKLIEMAKQEVEKQRKLMESVNIGGENVSSEYSSMAQDEDGTSNEAEEL 572

  Fly   481 --QIELEKKLVEIAERKKREIEIQQ-QLELQE-ETTLEIRERNVSLEQEVELKKRKLSKCYAKYL 541
              :.:|::...|.||.|:.:.|.:. |::|.| ...|:|:|:.:...:..|.:.:::.:.|.|.|
 Worm   573 LDEEDLDEDEDETAEEKQEQEESEALQIDLSEVMIELDIKEKLIDQLERAERQNQQIRETYEKKL 637

  Fly   542 -ALQQELNDCKSDHNQDLRE--LEMAQNELVKELKR--QLLIID---NFVPIEV--KQRLYTQAK 596
             .|.:.:.|.:::.::.|.|  .....||.:|.:|:  :|.|.|   ....||.  |:.|...||
 Worm   638 RELMERIKDTETERDRVLNEGGKRGGNNEQMKAIKQEYELKITDLRKELKKIEALDKEHLKVIAK 702

  Fly   597 YDEE-QEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQEAKSNSPSSLRFKSENIV 660
            ...| ||:.:..|..:...   ..|....:.::..::::.|.:.|...|.:......|.::..|.
 Worm   703 SQRELQEKTRLKSEVVDLK---KAKVELIKKMNEDKKKQKTQQLANARAFATKEKQTRLQANKIR 764

  Fly   661 NYELEMPCR------TTQEYRTPKVSASLQAVLA----QAMQTGGDDIDIVDSHTNSLRSRLENI 715
            ..|::...|      ||||....:...::.|..|    :....||..:      |||...|:..:
 Worm   765 TLEMKDKQREQFLKKTTQEVNALRKEKAVAAATARQANRGTPRGGAAV------TNSPARRVRGV 823

  Fly   716 I 716
            :
 Worm   824 V 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	147/368 (40%)
		Smc	<431..>580	CDD:440809	46/213 (22%)
klp-12	NP_001023349.1	KISc_KIF4	4..359	CDD:276823	146/363 (40%)
		CCDC158	<367..>791	CDD:464943	88/433 (20%)
		PRK03918	<602..>791	CDD:235175	42/191 (22%)
		Rcc_KIF21	857..931	CDD:410202
		WD40	1277..1601	CDD:238121
		WD40 repeat	1288..1322	CDD:293791
		WD40 repeat	1327..1364	CDD:293791
		WD40 repeat	1373..1429	CDD:293791
		WD40 repeat	1439..1482	CDD:293791
		WD40 repeat	1489..1524	CDD:293791
		WD40 repeat	1531..1556	CDD:293791