Protein Alignment Klp68D and klp-11

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001369897.1
• Gene: klp-11 / 177685
• WormBaseID: WBGene00002222
• Length: 782
• Species: Caenorhabditis elegans
• Alignment Length: 767
• Identity: 313/767 - (40%)
• Similarity: 457/767 - (59%)
• Gaps: 108/767 - (14%)

  Fly    18 ECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTL 82
            |.|:|:|||||:|::|.:....::|::.|.||.:||:|..: ..|..|.||:||.||.::||:.|
 Worm    12 ETVKVIVRCRPLSSQEIANNYSKIVHMRPQRGQIELKNPKE-QDEPSKDFTFDAIYDENSTQSDL 75

  Fly    83 YHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTENFQ 147
            |.|....||.|||.|:|..||||||||||||.||||...:.|..|:|.:..:.|:.|:..:.|.:
 Worm    76 YEETFRDLVDSVLNGYNATIFAYGQTGTGKTHTMEGKSSDPEQRGVIYKCIDHIFEHMAASHNQE 140

  Fly   148 FLVDVSYLEIYMEELRDLLKPNS-KHLEVRER-GSGVYVPNLHAINCKSVEDMIKVMQVGNKNRT 210
            :||..||||||.|||||||:..| |.||::|| ..||||.:|.:...::|.::.:||..||.:|:
 Worm   141 YLVRASYLEIYQEELRDLLEAESNKKLEIKERPDGGVYVKDLTSKLTRTVGEIHEVMIRGNGHRS 205

  Fly   211 VGFTNMNEHSSRSHAIFMIKIEMC-----DTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEA 270
            ||.||||||||||||||:|.:| |     |.|:: |.||:|||:|||||||||||||:.||.|||
 Worm   206 VGRTNMNEHSSRSHAIFIITVE-CSRIGEDGESH-ITVGRLNLVDLAGSERQSKTGATGERFKEA 268

  Fly   271 SKINLALSSLGNVISALAES-SPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTT 334
            :||||:||:||||||||.:: |.|:|||||||||||||||||||||:|:|.|||::||:.|||.|
 Worm   269 TKINLSLSALGNVISALVDAKSAHIPYRDSKLTRLLQDSLGGNSKTVMVACIGPASYNFEETLGT 333

  Fly   335 LRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPKKET 399
            ||||:|||:|:|||..||||:||.|:|:|||||.|:..: .|::.||....|......::.|.|
 Worm   334 LRYANRAKNIKNQPKINEDPKDALLREFQEEIEMLREQL-KQRKTRSRDGATQSFYDAERAKLE- 396

  Fly   400 VTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERERVENSKLAAKLAELEG 464
                       ..||...:|||   ..:.|.|:... |:.:.::.||:||:|.:::|.::|.::.
 Worm   397 -----------DDIEAIQKDDS---LIKHEKDRLIR-EIQEKHDLLEKERIEQARVAERIANIQS 446

  Fly   465 QLVRGGK---NLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEV 526
            :|:.|.:   .|.....|:..:||||..|:||:|:||.|:.:.||.|||.|:::::....|..||
 Worm   447 RLIVGSEEDGRLESRTKEQHAQLEKKRRELAEQKRREREMVEALERQEEDTVDLKQTFSDLRTEV 511

  Fly   527 ELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRL 591
            |.|.:||.|...|....:.|:.|....::.:.::|:....|:.||||.:|||::||:|.:|.:|:
 Worm   512 EAKTKKLKKMLIKLRQARNEIRDVSGAYSDERQDLDQTIAEVSKELKLKLLIVENFIPRDVSERI 576

  Fly   592 YTQAKYDEEQEEW-----KFSSMSLPTP-------------------------PGGDG-----KF 621
            ..:|:::|:..||     :.:|.:..||                         .||:|     :|
 Worm   577 KERAEWNEDSFEWNVNAFQSTSSNSSTPLNNTIEVNEDGVFTRSSGADSGVSVSGGNGTPATSQF 641

  Fly   622 SSKRPVSHPQRRRPTS-------EYALQE--AKSNSPSS--------------LRFKSENIVNYE 663
            ..||.|:.|..|||.|       |.|.::  |:...|.|              :||..||:|.:
 Worm   642 LDKRLVATPGCRRPMSMCERMLVETAREQFGAQRRPPISGSGSFVEATIPEETIRFCGENVVVF- 705

  Fly   664 LEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIVDSHTNSLRSRLENI 715
                  :..|...|:|:.|..:..:.:|.            .::.|..:||:
 Worm   706 ------SALERFVPEVTDSDPSTFSNSMM------------MSARRPSIENL 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	194/338 (57%)
		Smc	<431..>580	CDD:440809	50/151 (33%)
klp-11	NP_001369897.1	Motor_domain	12..343	CDD:473979	191/333 (57%)
		Smc	<358..>558	CDD:440809	65/216 (30%)