Protein Alignment Klp68D and Kif6

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001418110.1
• Gene: Kif6 / 171291
• RGDID: 621070
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 784
• Identity: 213/784 - (27%)
• Similarity: 354/784 - (45%)
• Gaps: 152/784 - (19%)

  Fly    18 ECVQVVVRCRP-----------MSNRERSERSPEVVNVYPNRGVVELQNVVDG---NKEQRKVFT 68
            :.:|:..|.:|           :...|:...|.|:  |.|       :::.||   ||.:...|.
  Rat     4 QTIQIFARVKPSVRKQQQGIYSIDEDEKLASSLEI--VLP-------RDLADGFVNNKRESYKFK 59

  Fly    69 YDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTF 133
            :...:|..|.|..::..:..|:..|.|.|:||.||||||||:|||||:.|........||||||.
  Rat    60 FQRIFDQEAKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTL 124

  Fly   134 EQIWLHINRTENFQFLVDVSYLEIYMEELRDLLKP--NSKHLE-------VRERGSGVYVPNLHA 189
            ..|:..:.:..:..:...:||||||.|...|||.|  .:..||       :.:....:::.||..
  Rat   125 SYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLKNLSL 189

  Fly   190 INCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGS 254
            ....:.|:.:.::.:|:.||.:..|.||:.|:|||.||.:.:...:..:.|::..||:|:|||||
  Rat   190 HQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSATVRHAKLHLVDLAGS 254

  Fly   255 ERQSKTGASAERLKEASKINLALSSLGNVISALAES-SPHVPYRDSKLTRLLQDSLGGNSKTIMI 318
            ||.||||.....|.||..|||:|..|..||.||:|. ..|:|||:|.:|.:|:||||||..|.||
  Rat   255 ERVSKTGVGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIPYRNSMMTSVLRDSLGGNCMTTMI 319

  Fly   319 ANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNE--DP---------QDAKLKE----------- 361
            |.:.....|.:|:::|.|:|.|...|:|:.|.||  ||         :.|.||.
  Rat   320 ATLSLEKRNIDESISTCRFAQRVALIKNEAILNEEIDPRLMIVRLQKEIADLKAELAMVTGEQRT 384

  Fly   362 ---YQEEIERLKRLIG---PQQQQRSEKQVTAKKQRV-------KKPKKETVTKEMSDSLQVST- 412
               .:.|:.:|::||.   ..|...|..:|.|..:::       ||...:..|.|.:||.:.:|
  Rat   385 EALTEAELLQLEKLIASFVEDQDPESRLEVGADLRKIHYCFHHFKKLLNDKKTLENTDSSESTTQ 449

  Fly   413 --IEQPVEDDSDPEGAESESDKENE---------AEVAKSNEELERERVENSK---------LAA 457
              .::||:|:...:.......::||         .|..|:.:.|:....|.|:         :|.
  Rat   450 QACQEPVKDEEYTKLRSLLKQRDNEINILVNMLKKEKKKTQDALQYSSTEKSEARPPPNSPFIAG 514

  Fly   458 KLAELEGQLVRGGKNL-----LDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRE 517
            ..|   ||......:|     |..|..|...|.||           ..:::::.|..:...||.:
  Rat   515 SPA---GQRTSFSSSLSQTQDLSVYRHRSSLLHKK-----------TGMREEMSLGRQEAFEIFK 565

  Fly   518 RNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNF 582
            |:.:....:|..|:.|.:.:::..||.:.:|:.:|...| |:| .::|..|.:.   .|.|.::.
  Rat   566 RDHADSVTIEDNKQVLKQRFSEAKALGESINEARSKIGQ-LKE-AISQRHLQQV---ALGIAESM 625

  Fly   583 VPIEV----KQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQ- 642
            .|...    :|:|  :|:.:||:..:|.:.|.|.         :.|..:.|.|.....::..||
  Rat   626 APPSTPDPQEQKL--RAQLEEEKSRYKTTFMRLK---------ALKVEIEHLQLLMDKAKLKLQK 679

  Fly   643 --------EAKS---NSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGD 696
                    ||.|   |||::      |:.:.....|.:...:..:.|.|..|:      ::.|..
  Rat   680 EFEAWWAEEASSLQVNSPAT------NLQDAAKPFPQQDQTQLLSKKSSQGLE------VENGAG 732

  Fly   697 DIDI 700
            .:|:
  Rat   733 KLDV 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	125/354 (35%)
		Smc	<431..>580	CDD:440809	36/171 (21%)
Kif6	NP_001418110.1	KISc_KIF9_like	5..343	CDD:276826	122/346 (35%)
		GumC	<558..>690	CDD:442439	32/147 (22%)