Protein Alignment Klp68D and Kif9

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001398108.1
• Gene: Kif9 / 16578
• MGIID: 1098237
• Length: 824
• Species: Mus musculus
• Alignment Length: 764
• Identity: 205/764 - (26%)
• Similarity: 315/764 - (41%)
• Gaps: 195/764 - (25%)

  Fly     6 RRPGTGSSQ-----TPNECVQVVVRCRP-------MSNRERSERSPEV-VNVYPNRGVVELQNVV 57
            :|...||.|     ...:.||..||.||       |.......:|.:: :.....||||
Mouse     2 KRHKNGSKQYLTKMGTRKKVQAFVRVRPTDDFAHEMIKYGEDNKSIDIHLKKDTRRGVV------ 60

  Fly    58 DGNKEQRKVFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGN 122
             .|::....|..|.... :|:|..:|..|....||..|:|:||.|..|||||.|||:||.|...|
Mouse    61 -NNQQTDWSFKLDGVLH-NASQDLVYETVAKDAVSQALDGYNGTIMCYGQTGAGKTYTMTGATEN 123

  Fly   123 DELMGIIPRTFEQIWLHINRTENFQFLVDVSYLEIYMEELRDLLK------PNSKHLEVRERGSG 181
            .:..||:||..:|::..|.........|.|||||||.|.|.|||.      |:...:.:.|...|
Mouse   124 YKHRGILPRALQQVFRMIEERPTHAITVRVSYLEIYNENLFDLLSTLPYVGPSVTPMTIVENPQG 188

  Fly   182 VYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIK---- 242
            :::..|........||...::..|..||.:....||::|||||.||.|.:|   ..:.|:.
Mouse   189 IFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYME---AHSRTLSDEKY 250

  Fly   243 -VGKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESS-PHVPYRDSKLTRLL 305
             ..|:||:|||||||.||||:....||||:.||.:||.|...|.||.:.: .|||:|.||||..|
Mouse   251 ITSKINLVDLAGSERLSKTGSEGRVLKEATYINKSLSFLEQAIIALGDQNRDHVPFRQSKLTHAL 315

  Fly   306 QDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAK---------------------------- 342
            :||||||...:::.||.......:|||::||:|||.|
Mouse   316 KDSLGGNCNMVLVTNIYGEAAQLDETLSSLRFASRMKLVTTEPAINEKYDAERMVKNLEKELALL 380

  Fly   343 --------SIQNQPIKNEDPQD--------AKLKEYQE----EIERLK-----------RLIGPQ 376
                    |:.|:.:.|.||.|        ::::.|.|    ||:.:.           |::..|
Mouse   381 KQELAIHDSLSNRTLVNYDPMDEIQIAEINSQVRRYLEGTLDEIDIINLRQIQEVFNQFRVVLSQ 445

  Fly   377 QQQRSEKQVTAK--------------KQRV------------------------------KKPK- 396
            |:|..|..:..|              .|:|                              ||||
Mouse   446 QEQEVESALRRKYTLIDKNDFAAISAVQKVGLMDIEGNLVGEPDGQSFGLGVAPFSVKPGKKPKT 510

  Fly   397 KETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEE------LERERVENSKL 455
            |:|...:.|.|.:......||      .|.:.:....::.::..|:::      |.||| |.|.:
Mouse   511 KKTPKDQFSSSARKEGASSPV------SGKDFDVASISKTQLIPSSKDGDLKDMLARER-ETSSI 568

  Fly   456 AAKLAELEGQLVRGGK---------NLLDTYSERQIELEKKLVE----IAERKKREIEIQQQLEL 507
            ...:::...:.:|..:         ...:..:||..|:.:...|    :.|||||..|..|::..
Mouse   569 EPLISDSPKEELRAPRPSTPPSRTVAFEEFKNERGSEINRIFKENKSILNERKKRASETTQRINA 633

  Fly   508 QEETTLEIRERNVSL-------EQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQ 565
            .::   ||.|...:|       |::.|.:.:.|.....:...|..:|.|.|..:..:.:||
Mouse   634 IKQ---EIDETKDALNFQKSLREKQGEYENKGLMIIDEEEFLLILKLKDLKKQYRNEYQEL---- 691

  Fly   566 NELVKELKRQLLIIDNFVPIEVKQRLYTQAKYD--EEQEEWKFSSMSLP 612
                ::|:.:         |:..|||..|.::.  .|.:.|...|..:|
Mouse   692 ----RDLRAE---------IQYCQRLVDQCRHRLLMEFDIWYNESFMIP 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	132/386 (34%)
		Smc	<431..>580	CDD:440809	33/174 (19%)
Kif9	NP_001398108.1	KISc_KIF9_like	20..352	CDD:276826	129/342 (38%)