Protein Alignment Klp68D and Kif5b

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_032474.2
• Gene: Kif5b / 16573
• MGIID: 1098268
• Length: 963
• Species: Mus musculus
• Alignment Length: 762
• Identity: 237/762 - (31%)
• Similarity: 374/762 - (49%)
• Gaps: 105/762 - (13%)

  Fly    16 PNEC-VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQ 79
            |.|| ::|:.|.||: |.....|..:.|..:.....|.:.:         |.:.:|..:.:|.:|
Mouse     4 PAECNIKVMCRFRPL-NESEVNRGDKYVAKFQGEDTVMIAS---------KPYAFDRVFQSSTSQ 58

  Fly    80 TTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI-NRT 143
            ..:|::....:|..||||:||.|||||||.:|||.||||...:.|.||||||..:.|:.:| :..
Mouse    59 EQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMD 123

  Fly   144 ENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGV-YVPNLHAINCKSVEDMIKVMQVGNK 207
            ||.:|.:.|||.|||::::||||..:..:|.|.|..:.| ||.........|.::::..:..|..
Mouse   124 ENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKS 188

  Fly   208 NRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEASK 272
            ||.|..|||||||||||:||:|.::..:|:|.....|||.|:||||||:.|||||....|.||..
Mouse   189 NRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKN 253

  Fly   273 INLALSSLGNVISALAESSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRY 337
            ||.:||:||||||||||.|.:|||||||:||:||||||||.:|.::....||:||.:||.:||.:
Mouse   254 INKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLF 318

  Fly   338 ASRAKSIQNQPIKN-EDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPKKETVT 401
            ..|||:|:|....| |...:...|:|::|.|:.|.|....|...:|.......:.|  |..|...
Mouse   319 GQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETV--PIDEQFD 381

  Fly   402 KEMSDSLQVSTIEQPVEDDSDPEGAE-----SESDKEN---EAEVAKSNEELERERVENSKLAAK 458
            ||.: :|:..|.::.:...||...|.     |.:|.|.   |.|:||..::|:.:..|.::.:..
Mouse   382 KEKA-NLEAFTADKDIAITSDKPAAAVGMAGSFTDAERRKCEEELAKLYKQLDDKDEEINQQSQL 445

  Fly   459 LAELEGQLVRGGKNLLDTYSER---QIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNV 520
            :.:|:.|::...:.|..|..::   |.||.:..   ||....:.|:::.|:..||..:...:::.
Mouse   446 VEKLKTQMLDQEELLASTRRDQDNMQAELNRLQ---AENDASKEEVKEVLQALEELAVNYDQKSQ 507

  Fly   521 SLE---QEVELKKRKLSKCYAKYLALQQELNDCKS-DHNQDLRELEMAQNELVKELKRQLLIIDN 581
            .:|   :|.||...:|::..|...::..||...|. .::|..|..||..: |:|:|....:.:.|
Mouse   508 EVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMAS-LLKDLAEIGIAVGN 571

  Fly   582 FVPIEVKQ--------------RLY----------------------TQAKYDEEQEEWKFSSMS 610
               .:|||              |||                      |::....|:.|.:.::..
Mouse   572 ---NDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQ 633

  Fly   611 LPTPPGGDGKFSSKRPVSHPQRRRPTSEYA--LQEAKSNSPSSLRFKSENIVNYELEMPCRTTQE 673
            |             |...|..:.:..:||.  :::.|.....|:....|.:|....:......::
Mouse   634 L-------------RISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRAQEKVHEMEK 685

  Fly   674 YRTPKVSASLQAVLAQAMQTGGDDIDIVDSH-------TNSLRSRLE 713
            ....||..:.:...|...|        :.||       .:|||..:|
Mouse   686 EHLNKVQTANEVKQAVEQQ--------IQSHRETHQKQISSLRDEVE 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	147/332 (44%)
		Smc	<431..>580	CDD:440809	37/158 (23%)
Kif5b	NP_032474.2	KISc_KHC_KIF5	6..325	CDD:276820	147/328 (45%)
		SMC_prok_B	<417..803	CDD:274008	65/336 (19%)
		Khc_CBD_cc	834..903	CDD:467880
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963
		Globular	915..963