DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Klp68D and Kif5a

DIOPT Version :10

Sequence 1:NP_524029.2 Gene:Klp68D / 39332 FlyBaseID:FBgn0004381 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_032473.2 Gene:Kif5a / 16572 MGIID:109564 Length:1027 Species:Mus musculus


Alignment Length:621 Identity:215/621 - (34%)
Similarity:332/621 - (53%) Gaps:73/621 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 SQTPNEC-VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDAS 76
            ::|.||| ::|:.|.||: |:....|..:.:.::.....|    ::.|     |.:.:|..:..:
Mouse     2 AETNNECSIKVLCRFRPL-NQAEILRGDKFIPIFQGDDSV----IIGG-----KPYVFDRVFPPN 56

  Fly    77 ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI- 140
            .||..:||.....:|..||.|:||.|||||||.:|||.||||...:.:|||||||....|:.|| 
Mouse    57 TTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIY 121

  Fly   141 NRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGV-YVPNLHAINCKSVEDMIKVMQV 204
            :..||.:|.:.|||.|||::::||||.....:|.|.|..:.| :|.........|.|:::.|:..
Mouse   122 SMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDE 186

  Fly   205 GNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKE 269
            |..||.|..|||||||||||:||:|.|:..:.||.....|||.|:||||||:.|||||....|.|
Mouse   187 GKSNRHVAVTNMNEHSSRSHSIFLINIKQENVETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDE 251

  Fly   270 ASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLT 333
            |..||.:||:|||||||||| :..:|||||||:||:||||||||.:|.|.....||:||..||.:
Mouse   252 AKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKS 316

  Fly   334 TLRYASRAKSIQNQPIKN-EDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAK--------K 389
            ||.:..|||:|:|....| |...:...|:|::|.|:.|          ::|:..||        :
Mouse   317 TLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTK----------AQKETIAKLEAELSRWR 371

  Fly   390 QRVKKPKKETVTKEMSDSLQVSTI--EQPVEDDSD------PEGAESESDKENEAEVAKSNEELE 446
            .....|:.|.:..|  ||...:.:  |.||.|:|.      ||  |.:..:|....:.|..::.:
Mouse   372 NGENVPETERLAGE--DSALGAELCEETPVNDNSSIVVRIAPE--ERQKYEEEIRRLYKQLDDKD 432

  Fly   447 RERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEI-AERKKREIEIQQQLELQEE 510
            .|..:.|:|..||.:   |::...:.|:.|..:.: :::::|..: :|....:.|:::.|:..||
Mouse   433 DEINQQSQLIEKLKQ---QMLDQEELLVSTRGDNE-KVQRELSHLQSENDAAKDEVKEVLQALEE 493

  Fly   511 TTLEIRERNVSLEQEVELKKR-------KLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNEL 568
            ..:...:::    ||||.|.:       :||:..|..|:|:.||...:.......:.:....|.|
Mouse   494 LAVNYDQKS----QEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGL 554

  Fly   569 VKELKRQLLIIDN---FVPIEVK---------QRLY 592
            :::|....:|:.|   .:|:|:.         .|||
Mouse   555 MRDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLY 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp68DNP_524029.2 KISc 20..351 CDD:214526 150/333 (45%)
Smc <431..>580 CDD:440809 32/156 (21%)
Kif5aNP_032473.2 KISc_KHC_KIF5 7..327 CDD:276820 150/329 (46%)
Microtubule-binding 174..315 80/140 (57%)
Necessary for interaction with ZFYVE27. /evidence=ECO:0000269|PubMed:21976701 271..361 41/99 (41%)
Interaction with BICD2. /evidence=ECO:0000250|UniProtKB:Q12840 353..1027 55/260 (21%)
PRK03918 <409..920 CDD:235175 41/192 (21%)
Khc_CBD_cc 832..901 CDD:467880
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 906..937
Globular 907..1027
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.