Protein Alignment Klp68D and Kif4

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_032472.2
• Gene: Kif4 / 16571
• MGIID: 108389
• Length: 1231
• Species: Mus musculus
• Alignment Length: 837
• Identity: 241/837 - (28%)
• Similarity: 403/837 - (48%)
• Gaps: 160/837 - (19%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLYH 84
            |:|.:||||:.::|..|.....::..|..     ..||.||.   |.||||..:|.|..|..:::
Mouse    10 VRVALRCRPLVSKEIKEGCQTCLSFVPGE-----PQVVVGND---KSFTYDFVFDPSTEQEEVFN 66

  Fly    85 EVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGV----RGNDELMGIIPRTFEQIWLHINRTEN 145
            ..|.||:..|.:|:|..:.||||||:|||::|.|.    :.:|..:|:|||..:.::..||:..:
Mouse    67 TAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKSD 131

  Fly   146 FQFLVDVSYLEIYMEELRDLL---KPNSKHLEVRE-RGSGVYVPNLHAINCKSVEDMIKVMQVGN 206
            |:|.:.|||||||.||:.|||   :..:..:.:|| ...|:.:..|.........|.:..::.||
Mouse   132 FEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGN 196

  Fly   207 KNRTVGFTNMNEHSSRSHAIFMIKIEM-CDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEA 270
            .:|||..|.||..||||||||.|.||. ...:.|:....||:|:||||||||.||.|..:||:|.
Mouse   197 NSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREG 261

  Fly   271 SKINLALSSLGNVISALAESSP--HVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLT 333
            ..||..|..||||||||.:...  .||||||||||||||||||||.|:|||.:.|::.|..|||.
Mouse   262 ININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLN 326

  Fly   334 TLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRL--------------IGPQQ------- 377
            |||||.||:.|:|:||.|.|||.|:|...::::::|:.|              :.|.:
Mouse   327 TLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLPGDINVEPSENLQSLME 391

  Fly   378 ---------------------------------QQRSEKQVTAKKQRVKKPKK---------ETV 400
                                             :|.:|| :.||.:.:::...         ||:
Mouse   392 KNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEK-MNAKLEELRRHAACKVDLQKLVETL 455

  Fly   401 -TKEMSDSLQ-VSTIEQPVEDDSDPEGA----------ESESDKENEAEVAKSNE---------- 443
             .:|:.:::: :..::|.:...||...|          |:::..::..:.::|::
Mouse   456 EDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQSSPDTSRSSDVFSTQHALRQ 520

  Fly   444 -ELERERVENSK-------LAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIE 500
             ::.:|.:|.:|       ||.|:.:.:.||    :.:...|.:....||.:::.: :|:|.|:.
Mouse   521 AQMSKELIELNKALALKEALAKKMTQNDNQL----QPIQFQYQDNIKNLESEVLSL-QREKEELV 580

  Fly   501 IQQQLELQEETTLEIRERNVSLEQEVELK----KRKLSKCYAKYLALQQELNDCKSDHNQDLREL 561
            ::.|...::....::.||.....||:|.:    |:||.: .:|.|.|::......|..||::|.:
Mouse   581 LELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQE-QSKLLKLKESTEHTVSKLNQEIRMM 644

  Fly   562 EMAQNELVKELK------RQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMS-LPTPPGGDG 619
            :..:.:|::::|      ||.....:...|::|:| ..:.:|:..:.|..|...| :......:.
Mouse   645 KNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKER-DRKRQYELLKLERNFQKQSNVLRRKTEEA 708

  Fly   620 KFSSKRPVSHPQRRRPTSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYR-------TP 677
            ..::||.....|:::..:| ..:|.:|....|...:.:|.:..|:|:...|.:..|       ..
Mouse   709 AAANKRLKDALQKQKEVAE-KRKETQSRGMESTAARMKNWLGNEIEVMVSTEEAKRHLNGLLEER 772

  Fly   678 KVSASLQAVLAQAMQTG------------------GDDIDIVDS---HTNSLRSRLE 713
            |:.|...|.|.:..::|                  |.|....||   ...||.:.||
Mouse   773 KILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELE 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	152/341 (45%)
		Smc	<431..>580	CDD:440809	35/176 (20%)
Kif4	NP_032472.2	KISc_KIF4	8..338	CDD:276823	148/335 (44%)
		Smc	<518..>1005	CDD:440809	66/320 (21%)
		Globular	1001..1231
		Pre-SET	<1082..1120	CDD:461530
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1189..1212