DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif3b

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_032470.3	Gene:	Kif3b / 16569	MGIID:	107688	Length:	747	Species:	Mus musculus

Alignment Length:	798	Identity:	362/798 - (45%)
Similarity:	504/798 - (63%)	Gaps:	87/798 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTT 81
            :|.|:||||||||:.:|::....:||:|....|.|.::|....:.|..|.||:||.||.:|.|..
Mouse     7 SESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTSHEMPKTFTFDAVYDWNAKQFE 71

  Fly    82 LYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTENF 146
            ||.|...|||.|||:||||.||||||||||||:|||||||:.|..|:||.:|:.|:.||:|::|.
Mouse    72 LYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPEKRGVIPNSFDHIFTHISRSQNQ 136

  Fly   147 QFLVDVSYLEIYMEELRDLL-KPNSKHLEVRER-GSGVYVPNLHAINCKSVEDMIKVMQVGNKNR 209
            |:||..||||||.||:|||| |..:|.||::|| .:||||.:|.:...|||:::..||.|||:||
Mouse   137 QYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNR 201

  Fly   210 TVGFTNMNEHSSRSHAIFMIKIEMCDT---ETNTIKVGKLNLIDLAGSERQSKTGASAERLKEAS 271
            :||.||||||||||||||:|.||..:.   ..|.|:||||||:||||||||:||||..||||||:
Mouse   202 SVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEAT 266

  Fly   272 KINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTL 335
            ||||:||:||||||||.: .|.|:||||||||||||||||||:||:|:||:||::||..||||||
Mouse   267 KINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTL 331

  Fly   336 RYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPK---- 396
            |||:|||:|:|:|..||||:||.|:|:||||.|||       .|..::.:..:|:|.|:.:
Mouse   332 RYANRAKNIKNKPRVNEDPKDALLREFQEEIARLK-------AQLEKRSIGRRKRREKRREGGGS 389

  Fly   397 --------------------KETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKS 441
                                |:...:|..:.|::.. ...|||.|.....:....||.|    |.
Mouse   390 GGGGEEEEEEGEEGEEDGDDKDDYWREQQEKLEIEK-RAIVEDHSLVAEEKMRLLKEKE----KK 449

  Fly   442 NEELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAERKKREIEIQQQLE 506
            .|:|.||:.....|.||:..:|.:|:.||||::|..:|:|..||:|..||||:|:||.|||||:|
Mouse   450 MEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQME 514

  Fly   507 LQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKE 571
            .::|.|||::|...||:|||::|.:||.|.::|..|::.|::|.:.:|.::.:|||..||||.:|
Mouse   515 SRDEETLELKETYTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRE 579

  Fly   572 LKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPT 636
            ||.:.|||:||:|:|.|.::..::.:|:|::.||...::..     :.:...|||||....:||.
Mouse   580 LKLKHLIIENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRL-----ENQQMMKRPVSAVGYKRPL 639

  Fly   637 SEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIV 701
            |::|..........  |:::|||:..||:||.|||::|..|.:|..:||.|..|:| ..|:|.:.
Mouse   640 SQHARMSMMIRPEP--RYRAENIMLLELDMPSRTTRDYEGPAISPKVQAALDAALQ-DEDEIQVD 701

  Fly   702 DSHTNSLRSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRGLPSAASNLDSNRRPPTGRL 766
            .|...|..||...         |.|.:|...|||       .||.|.|:
Mouse   702 ASSFESTASRKPK---------ARPKSGRKSGSS-------SSSSGNPA---------------- 734

  Fly   767 PAKKPASAYPKARGLVNK 784
                 :..||::||||.|
Mouse   735 -----SQFYPQSRGLVPK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	205/331 (62%)
		KISc	20..351	CDD:214526	207/336 (62%)
		GBP_C	<479..576	CDD:303769	47/96 (49%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
Kif3b	NP_032470.3	KISc_KIF3	8..340	CDD:276822	205/331 (62%)
		Kinesin	15..340	CDD:278646	200/324 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..412		4/37 (11%)
		Globular	580..747		64/211 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..747		21/85 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836906
Domainoid	1	1.000	223	1.000	Domainoid score	I2562
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55849
Inparanoid	1	1.050	608	1.000	Inparanoid score	I925
Isobase	1	0.950	-	0	Normalized mean entropy	S1573
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002745
OrthoInspector	1	1.000	-	-		oto93194
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2170
SonicParanoid	1	1.000	-	-		X1829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.730