DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif3a

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_006532388.1	Gene:	Kif3a / 16568	MGIID:	107689	Length:	725	Species:	Mus musculus

Alignment Length:	736	Identity:	291/736 - (39%)
Similarity:	444/736 - (60%)	Gaps:	72/736 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SQTPNEC--VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDA 75
            |:.|..|  |:|||||||::.||:|....:.|:|...||.:.:.. .|.:.|..|.||:|..:..
Mouse     6 SEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHK-TDSSNEPPKTFTFDTVFGP 69

  Fly    76 SATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI 140
            .:.|..:|:....|::.|||||:||.|||||||||||||||||||....|.|:||.:|..|:.||
Mouse    70 ESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHI 134

  Fly   141 NRTE-NFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRERGS-GVYVPNLHAINCKSVEDMIKVM 202
            .:.| :.:|||.|||||||.||:|||| |..::.|||:||.. |||:.:|.|....:.:||.::|
Mouse   135 AKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIM 199

  Fly   203 QVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETN---TIKVGKLNLIDLAGSERQSKTGASA 264
            .:|:|||:||.||||||||||||||.|.||..:...:   .:::|||:|:||||||||:||||:.
Mouse   200 TLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATG 264

  Fly   265 ERLKEASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNY 328
            :|||||:||||:||:||||||||.: .|.|||||:|||||||||||||||||:|.|||||::|||
Mouse   265 QRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNY 329

  Fly   329 NETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQ---------QRSEKQ 384
            :||::|||||:|||:|:|:...||||:||.|:::|:|||.||:.:...::         :..:::
Mouse   330 DETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEE 394

  Fly   385 VTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVED-----------------------DSDPEGA 426
            ....:...||.|:...:...|.....|.||:|:::                       |.:.:..
Mouse   395 GELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVSPDKMVEMQAKIDEERKAL 459

  Fly   427 ESESDKENE------AEVAKSNEELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELE 485
            |::.|.|.|      ||:.:..::|.:.:.|:..|..||:.||.:::.||.:||....|::..||
Mouse   460 ETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLE 524

  Fly   486 KKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDC 550
            :..:|:.||::|..:::::||.:|:..|:|.|:..||::|.:.|.:||.|.:...:|.:.|:.|.
Mouse   525 ESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL 589

  Fly   551 KSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPP 615
            :.:|.:::..|.....:|.:||:.|:||||||:|.:.::.:.....::|:..||:...::..
Mouse   590 QQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYT--- 651

  Fly   616 GGDGKFSSKRPVSHPQRRRP----TSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRT 676
              ......:.||...:.|.|    .|...|...:.:...||         .:||.| ||::....
Mouse   652 --GNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSL---------MKLERP-RTSKGKAR 704

  Fly   677 PKV-----SASLQAVLAQAMQ 692
            ||:     ||..:.|:...:|
Mouse   705 PKMGRRKRSAKPETVIDSLLQ 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	190/334 (57%)
		KISc	20..351	CDD:214526	191/337 (57%)
		GBP_C	<479..576	CDD:303769	28/96 (29%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	189/332 (57%)
		SMC_N	<340..717	CDD:308206	100/391 (26%)
		SMC_prok_B	<449..>615	CDD:274008	46/165 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720