Protein Alignment Klp68D and Kif21b

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001034561.1
• Gene: Kif21b / 16565
• MGIID: 109234
• Length: 1624
• Species: Mus musculus
• Alignment Length: 992
• Identity: 260/992 - (26%)
• Similarity: 401/992 - (40%)
• Gaps: 313/992 - (31%)

  Fly    19 CVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLY 83
            ||:|.||.||..::|:.|......:|.|....|.|      .|:  |.||||..:|....|..:|
Mouse     8 CVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLL------GKD--KAFTYDFVFDLDTWQEQIY 64

  Fly    84 HEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTM----EGVRGNDELMGIIPRTFEQIWLHINRTE 144
            ...|..|:....||:|..:.||||||.|||:||    :.|...:| .|||||....::..|:..:
Mouse    65 STCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEE-QGIIPRAIAHLFRGIDERK 128

  Fly   145 NF---------QFLVDVSYLEIYMEELRDLL----KPNSKH----LEVRE-RGSGVYVPNLHAIN 191
            ..         :|.|...:||:|.||:.||.    .|:::|    :::.| ...|:|...:.:..
Mouse   129 RRAQEKGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTSRL 193

  Fly   192 CKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMI---KIEMC------------------- 234
            ..|.|::|:.::.|..:||...|.||..||||||||.|   ::.:|
Mouse   194 INSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGLPDGAAP 258

  Fly   235 -DTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESSP---HVP 295
             .||..|: ..|.:.:|||||||..:|||:.||.||...||..|.:||||||||.:.|.   |||
Mouse   259 TGTEYETL-TAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVP 322

  Fly   296 YRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLK 360
            ||||||||||||||||||:|||||.:.||:.::.|||.||:||:||::|:|:.:.|:|....::.
Mouse   323 YRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQIS 387

  Fly   361 EYQEEIERL----------KRLIGP---------------------------------------- 375
            ..:.||.||          ||:||.
Mouse   388 ALRAEIARLQMELMEYKAGKRVIGEDGTEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNR 452

  Fly   376 ------------------------------------------------QQQQRSEKQVTAK---- 388
                                                            :..:||..:.:|:
Mouse   453 VTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARNPYS 517

  Fly   389 ----------------------------------------KQRVKKPKKETVTK------EMSDS 407
                                                    :||.|.|:||...|      |.|:.
Mouse   518 LGASPAGPAFGGSPATSMEDASEVIRKAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQAENSEE 582

  Fly   408 LQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEEL-------ERERVENSKLAAKLAELEGQ 465
            ...:..|:. |::.|..|.|.|..:|:|.|.:.|.|.|       |.:.|   ...|.||:|
Mouse   583 TDENEAEEE-EEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEV---NFQADLADL--- 640

  Fly   466 LVRGGKNLLDTYSERQIELEKKLVEIAERKKREIE-IQQQLELQEETTLEIRERNVSLEQEVELK 529
                         ..:||:::||::..|..:|.:: ::.|.| ::...|:.:.|:..||::..|:
Mouse   641 -------------TCEIEIKQKLIDELENSQRRLQTLKHQYE-EKLILLQNKIRDTQLERDRVLQ 691

  Fly   530 KRKLSKCYAKYLALQQELNDCKSDH-------NQDLRELEMAQNELVKELKRQLLIIDNFVPIEV 587
            .....:||.     :::.|..|:|:       |:||::|:.||.|..:.||.|     :....|:
Mouse   692 NLSTMECYT-----EEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQ-----SRYEREL 746

  Fly   588 KQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYALQEAKSNSPSSL 652
            |       |...|..|.|.:.::|           .|:.....||||      |.|.|.|...:.
Mouse   747 K-------KLQAEVAEMKKAKVAL-----------MKQMREEQQRRR------LVETKRNREIAQ 787

  Fly   653 RFKSENIVNYE---LEMPCRTTQ---EYRTPKVSASLQAVLAQAMQTGGDDIDIVDSHTNSLRSR 711
            ..|.:....::   ||...|..:   ..:|.:|||..:  ||:.|             :..:..|
Mouse   788 LKKEQRRQEFQIRALESQKRQQEIVLRRKTQEVSALRR--LAKPM-------------SERVAGR 837

  Fly   712 LENIINANANGGAGPGAGVAVGSSIPNVRNIKS-----SRGL-------PSAASNLDSNRRPPTG 764
            : .:...|.:.||...|......:....|::.|     :|.:       |:|..|   ..||...
Mouse   838 V-GLKPPNMDSGAEVSASTTSSEAESGARSVSSIVRQWNRKIDHFLGDRPTATVN---GGRPARK 898

  Fly   765 RLPAKKPASAYPKARGL 781
            :...|..:.::.||..|
Mouse   899 KFQKKGASQSFSKAARL 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	147/378 (39%)
		Smc	<431..>580	CDD:440809	40/163 (25%)
Kif21b	NP_001034561.1	KISc_KIF4	7..372	CDD:276823	146/373 (39%)
		SMC_N	367..>1095	CDD:481474	116/623 (19%)
		Interaction with TRIM3. /evidence=ECO:0000269|PubMed:24086586	401..1100		106/589 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..629		22/76 (29%)
		EnvC	634..>831	CDD:443969	59/262 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	837..866		5/29 (17%)
		Rcc_KIF21B	930..1011	CDD:410203
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1199..1253
		WD40	1302..1615	CDD:238121
		WD 1	1308..1345
		WD40 repeat	1314..1348	CDD:293791
		WD 2	1348..1386
		WD40 repeat	1353..1389	CDD:293791
		WD40 repeat	1409..1452	CDD:293791
		WD 3	1412..1450
		WD 4	1453..1495
		WD40 repeat	1458..1502	CDD:293791
		WD 5	1504..1541
		WD40 repeat	1511..1543	CDD:293791
		WD 6	1545..1584
		WD40 repeat	1550..1574	CDD:293791