DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and Kif12

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001304281.1	Gene:	Kif12 / 16552	MGIID:	1098232	Length:	643	Species:	Mus musculus

Alignment Length:	780	Identity:	208/780 - (26%)
Similarity:	297/780 - (38%)	Gaps:	253/780 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKSRRPGTGSSQTPNECVQVVVRCRPMSNRE--RSERS------PEVVNVYPNRGVVELQNVVDG 59
            |::...|...|:||   :|||:|.||||..|  |.|:|      ...:.|.|:
Mouse    12 ARNLEQGPEGSETP---IQVVLRVRPMSTVELRRGEQSALHCSGTRTLQVSPD------------ 61

  Fly    60 NKEQRKVFTYDAAYDASATQTTLYHEV-VFPLVSSVLEGFNGCIFAYGQTGTGKTFTM------- 116
                 ..|.:.|..|.:.||..::... |..|....|.||:..:|.:||||:|||:|:
Mouse    62 -----VAFRFGAVLDGARTQEDVFRACGVKRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQG 121

  Fly   117 EGVRGNDELMGIIPRTFEQIWLHINRTENFQFLVDV--SYLEIYMEELRDLLKPNS-KHLEVR-E 177
            |||.....|.||:.|||  .|| ::|.::....|.:  ||||||.|::.|||...| :.|.|| .
Mouse   122 EGVPVPPSLAGIMQRTF--TWL-LDRVQHLDSPVTLRASYLEIYNEQVWDLLSLGSPRPLPVRWT 183

  Fly   178 RGSGVYVPNLHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIK 242
            :..|.||..|..:...|:|.:::::|:|...|......:|:.||||||:..:.|.. .|......
Mouse   184 KARGFYVEQLRVVEFGSLEALMELLQMGLSRRRSSSHTLNQASSRSHALLTLHISR-PTSQQVPP 247

  Fly   243 V--------GKLNLIDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAE---SSPHVPY 296
            |        |||..:||||||:.:.||:..:.:.||:.||.:|.:||:.||.|.:   ...|:|:
Mouse   248 VDLGEPPVGGKLCFVDLAGSEKVAATGSQGQLMLEANSINRSLLALGHCISLLLDPQRKQNHIPF 312

  Fly   297 RDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKE 361
            ||||||:||.|||||...|:|:|.:.||.....|||:||||||||:.|..:|
Mouse   313 RDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRITTRP------------- 364

  Fly   362 YQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGA 426
                       .||            |...||.|                   |.||:
Mouse   365 -----------QGP------------KSPGVKPP-------------------QQVEN------- 380

  Fly   427 ESESDKENEAEVAKSNEELERERVENSKLAAKLAELE--------GQLVRGGKNLLDTYSERQIE 483
                             ||.|.:.||..|..:|.::.        .::....:||.....|..:|
Mouse   381 -----------------ELLRLQEENRHLRFQLDQMHTTAPGAHGARMAWAQRNLYGMLQEFMLE 428

  Fly   484 LEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELN 548
                    .||.::|:.     :|:....|...|:.|..:|..:|::|.||.|     .|.|:.:
Mouse   429 --------NERLRKEMR-----QLRSSRDLARAEQRVLAQQVHDLERRLLSAC-----PLPQQGS 475

  Fly   549 D-------------------CKSDHNQDL------------RELEMAQNELVKELKRQLLIIDNF 582
            .                   |...|...|            ||..|.|..|..|
Mouse   476 TPVCPCRMVPAASCHALPPLCYCHHFCPLCRVPLAHWTCPRRECHMPQQVLEPE----------- 529

  Fly   583 VPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYA------- 640
            .|..:.|.::        ...|      .|.|..|..|         |.|.|..|::.
Mouse   530 APGHISQSVW--------PPPW------APPPSPGSAK---------PPRERSQSDWTQTRVLAE 571

  Fly   641 -------------LQEAKSNSPSSLRFKSENIVNYELEMPCRTTQ-------EYRTPKVSASLQA 685
                         |....||.|..||..| .|.|....:...|.|       ..|.|:.|...|:
Mouse   572 MLMGEEVVPSAPPLSAGPSNMPYGLRGGS-GIPNLTPRLETLTQQINSSLHLSQRQPQPSEDTQS 635

Fly 686 685
Mouse 636 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	131/356 (37%)
		KISc	20..351	CDD:214526	133/361 (37%)
		GBP_C	<479..576	CDD:303769	26/127 (20%)
		coiled coil	547..558	CDD:293879	2/29 (7%)
Kif12	NP_001304281.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		3/12 (25%)
		KISc	25..358	CDD:276812	131/356 (37%)
		Kinesin	31..360	CDD:278646	128/349 (37%)
		Kinesin-relat_1	<379..464	CDD:289481	21/121 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..562		9/52 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..643		15/57 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810