Protein Alignment Klp68D and Kif11

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_034745.1
• Gene: Kif11 / 16551
• MGIID: 1098231
• Length: 1052
• Species: Mus musculus
• Alignment Length: 849
• Identity: 258/849 - (30%)
• Similarity: 388/849 - (45%)
• Gaps: 209/849 - (24%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLYH 84
            :||||||||.:..||...:..||.....|..|.::.....:|..:|.:|:|..:.||..|..:|.
Mouse    18 IQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSKKTYTFDMVFGASTKQIDVYR 82

  Fly    85 EVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRG--------NDELMGIIPRTFEQIW--LH 139
            .||.|::..|:.|:|..|||||||||||||||||.|.        .|.|.||||||..||:  |.
Mouse    83 SVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGIIPRTLHQIFEKLT 147

  Fly   140 INRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRER---------GSGVYVPNLHAINCKSV 195
            .|.||   |.|.||.||||.|||.|||.|:|   :|.||         ..||.:..|..|...:.
Mouse   148 DNGTE---FSVKVSLLEIYNEELFDLLSPSS---DVSERLQMFDDPRNKRGVIIKGLEEITVHNK 206

  Fly   196 EDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETN---TIKVGKLNLIDLAGSERQ 257
            :::.::::.|...||...|.||.:|||||::|.:.|.|.:|..:   .:|:|||||:||||||..
Mouse   207 DEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENI 271

  Fly   258 SKTGASAERLKEASKINLALSSLGNVISALAESSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIG 322
            .::||..:|.:||..||.:|.:||.||:||.|.:||:|||:|||||:|||||||.::|.:||.|.
Mouse   272 GRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRTRTSIIATIS 336

  Fly   323 PSNYNYNETLTTLRYASRAKSIQNQPIKNED-PQDAKLKEYQEEIERLKRLIGPQQQQR----SE 382
            |:::|..|||:||.||.|||:|.|:|..|:. .:.|.:|||.||||||||.:...:::.    ||
Mouse   337 PASFNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISE 401

  Fly   383 KQVTAKKQRVKKPKKETVTKEMSDSL--QVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEEL 445
            :...|...:|      ||.:|....|  :::.:|:.:.     :..|...|.:||.:..||:.:.
Mouse   402 ESFRAMNGKV------TVQEEQIVELVEKIAVLEEELS-----KATELFMDSKNELDQCKSDLQT 455

  Fly   446 ERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIE-LEKKLVEIAERKKREIEIQQQLELQE 509
            :.:.:|.::  ..|.|.:.|||:      :.|....:| .||.|.:.|.:         .|...:
Mouse   456 KTQELETTQ--KHLQETKLQLVK------EEYVSSALERTEKTLHDTASK---------LLNTVK 503

  Fly   510 ETTLEIRERNVS-LEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKE-- 571
            |||     |.|| |..:::.|:           |:.:...:.:....::|..|.....||:|:
Mouse   504 ETT-----RAVSGLHSKLDRKR-----------AIDEHNAEAQESFGKNLNSLFNNMEELIKDGS 552

  Fly   572 LKRQLLI-----------------IDNF----------VPIEV-------------KQRLYTQAK 596
            .|::.::                 :|..          :|..|             :|.|..|:|
Mouse   553 AKQKAMLDVHKTLFGNLMSSSVSALDTITTTALESLVSIPENVSARVSQISDMILEEQSLAAQSK 617

  Fly   597 ------YDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSH-------------PQRRRPTSEYA-- 640
                  .||...: .|:|:.....|......:..:.:.|             .|:|...|..:
Mouse   618 SVLQGLIDELVTD-LFTSLKTIVAPSVVSILNINKQLQHIFRASSTVAEKVEDQKREIDSFLSIL 681

  Fly   641 ---LQEAKSNSPSSL----------------------------------RF-----KSENIVNYE 663
               |.|.:.|:.|||                                  ||     |.|||
Mouse   682 CNNLHELRENTVSSLVESQKLCGDLTEDLKTIKETHSQELCQLSSSWAERFCALEKKYENI---- 742

  Fly   664 LEMPCRTTQE--------------YRTPKVSASLQAVLAQAMQTGGDDIDIVD---SHTNSLRSR 711
             :.|..:.||              ..:.|:.|....:|.:......:...:|:   .|.:||.|.
Mouse   743 -QKPLNSIQENTELRSTDIINKTTVHSKKILAESDGLLQELRHFNQEGTQLVEESVGHCSSLNSN 806

  Fly   712 LENI 715
            ||.:
Mouse   807 LETV 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	161/352 (46%)
		Smc	<431..>580	CDD:440809	33/169 (20%)
Kif11	NP_034745.1	KISc_BimC_Eg5	15..367	CDD:276815	162/354 (46%)
		PRK12704	349..>508	CDD:237177	53/191 (28%)
		CCDC158	415..>863	CDD:464943	78/440 (18%)
		Microtub_bind	915..1047	CDD:464048
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1026
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1052