Protein Alignment Klp68D and Khc

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_061508342.1
• Gene: Khc / 1271664
• VectorBaseID: AGAMI1_007845
• Length: 1027
• Species: Anopheles gambiae
• Alignment Length: 780
• Identity: 238/780 - (30%)
• Similarity: 386/780 - (49%)
• Gaps: 110/780 - (14%)

  Fly    10 TGSSQTPNE-CVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAY 73
            :|..:.|.| .::||.|.||:::.|....|..||. :|: |..|....:.|     ||:.:|..:
Mosquito     2 SGVREIPAEDSIKVVCRFRPLNDSEELAGSKFVVK-FPS-GPEENCLSIGG-----KVYLFDKVF 59

  Fly    74 DASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWL 138
            ..:|||..:|:|....:||.||.|:||.|||||||.:|||.|||||.|:....|||||....|:.
Mosquito    60 KPNATQEKVYNEAAKSIVSDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDPAKQGIIPRIVNDIFN 124

  Fly   139 HINRTE-NFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGV-YVPNLHAINCKSVEDMIKV 201
            ||...| |.:|.:.|||.||||:::||||..:..:|.|.|..:.| ||.........|.|::.:|
Mosquito   125 HIYTMEMNIEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGASERFVSSPEEVFEV 189

  Fly   202 MQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAER 266
            ::.|..||.:..|||||||||||::|:|.::..:.|......|||.|:||||||:.|||||....
Mosquito   190 IEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENMENEKKLSGKLYLVDLAGSEKVSKTGAEGTV 254

  Fly   267 LKEASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNE 330
            |.||..||.:||:|||||||||: :..|:|||||||||:||:|||||::|.::....|:::|.:|
Mosquito   255 LDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESE 319

  Fly   331 TLTTLRYASRAKSIQNQPIKNEDPQDAKLK-EYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKK 394
            |.:||.:..|||:::|....||:....:.| .|:.|.|:..:|.|..::..:|        ..:.
Mosquito   320 TKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEREKEKNTKLKGKIEKLEAE--------LARW 376

  Fly   395 PKKETVTKE-----MSDSLQVST------IEQPVE--------DDSDPEGAESESDKENEAEVAK 440
            ...|||..|     ..|:::.||      :.||.:        ....|..||.::.:.....:.:
Mosquito   377 RAGETVNVEEQLDLQQDAMEASTPNVEVLLAQPADLPVPATPGGGGLPLSAERDTLEVERERLYQ 441

  Fly   441 SNEELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEI-AERKKREIEIQQQ 504
            ..:|.:.|..:.|:...||.|   |::...:.:.:|..:.: .|:.::..| .|.:..:.|:::.
Mosquito   442 QLDEKDEEINQQSQYVEKLKE---QIIDQEELIANTRRDYE-NLQSEMTRIQQENENAKEEVKEV 502

  Fly   505 LELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQ---- 565
            |:..||..:...:::    ||:|||.:::.....:.|..|..||..:|: .|.|:::...|
Mosquito   503 LQALEELAVNYDQKS----QEIELKNKEIDMVNDELLQKQTTLNSVQSE-LQQLKDMSSHQKKRI 562

  Fly   566 NELVKELKRQLLIIDNFVPIEVKQ-RLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSK----- 624
            ||::..|.|.|..:...:..:..: ::..:|...:.:||:..:.:.:..........|::
Mosquito   563 NEMLTNLLRDLSEVGQALAADQNEMKMNVEASAGKVEEEFTVARLYISKMKSEAKNLSARCANLE 627

  Fly   625 -------RPV---------------SHPQRRRPTSEYALQEAKSNSPSSLRFKSENIVNYELEMP 667
                   |.|               .|..|.:     :|||:...:.:..|...|||
Mosquito   628 TLQQDTCRKVGDYEKDLSECRLLISQHEARMK-----SLQESMREAENKKRTLEENI-------- 679

  Fly   668 CRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIV---------DSHT---NSLR---SRLENIIN 717
            ....:|....|.:..:.||.|:..|. .|.:.:.         |.||   ::||   |..:.:||
Mosquito   680 DALREECAKLKAAEQVSAVNAEEKQR-ADQLKVAFESQMDQLRDVHTKQVSALRDEISEKQELIN 743

  Fly   718  717
            Mosquito   744  743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	151/333 (45%)
		Smc	<431..>580	CDD:440809	33/153 (22%)
Khc	XP_061508342.1	None