Protein Alignment Klp68D and KIF3A

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 298/739 - (40%)
• Similarity: 447/739 - (60%)
• Gaps: 77/739 - (10%)

  Fly    13 SQTPNEC--VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDA 75
            |:.|..|  |:|||||||::.||:|....:.|:|...||.:.:.. .|.:.|..|.||:|..:..
Human     6 SEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHK-TDSSNEPPKTFTFDTVFGP 69

  Fly    76 SATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI 140
            .:.|..:|:....|::.|||||:||.|||||||||||||||||||...||.||||.:|..|:.||
Human    70 ESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHI 134

  Fly   141 NRTE-NFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRERGS-GVYVPNLHAINCKSVEDMIKVM 202
            .:.| :.:|||.|||||||.||:|||| |..::.|||:||.. |||:.:|.|....:.:||.::|
Human   135 AKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIM 199

  Fly   203 QVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETN---TIKVGKLNLIDLAGSERQSKTGASA 264
            .:|:|||:||.||||||||||||||.|.||..:...:   .:::|||:|:||||||||:||||:.
Human   200 TLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATG 264

  Fly   265 ERLKEASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNY 328
            :|||||:||||:||:||||||||.: .|.|||||:|||||||||||||||||:|.|||||::|||
Human   265 QRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNY 329

  Fly   329 NETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKR------------LIGPQQQQRS 381
            :||::|||||:|||:|:|:...||||:||.|:::|:|||.||:            :.|.::....
Human   330 DETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDE 394

  Fly   382 EKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVED-----------------------DSDP 423
            |.:|....::.|| ::.:.:...||| ..|.||:|::.                       |.:.
Human   395 EGEVGEDGEKRKK-RRGSSSSSSSDS-TCSVIEKPLDKFLPNQAGKKKVSPDKMIEMQAKIDEER 457

  Fly   424 EGAESESDKENE------AEVAKSNEELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQI 482
            :..|::.|.|.|      ||:.|..::|.:.:.|:..|..||:.||.:::.||.:||....|::.
Human   458 KALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEK 522

  Fly   483 ELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQEL 547
            .||:..:|:.||:||..:::::||.:|:..|:|.|:..||::|.:.|.:||.|.:...:|.:.|:
Human   523 LLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEM 587

  Fly   548 NDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLP 612
            .|.:.:|.:::..|.....:|.:||:.|:||||||:|.:.::.:.....::|:..||:...::..
Human   588 ADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDYQEMIENYVHWNEDIGEWQLKCVAYT 652

  Fly   613 TPPGGDGKFSSKRPVSHPQRRRP----TSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQE 673
                 ......:.||...:.:.|    .|...|...:.:...||         .:||.| ||::.
Human   653 -----GNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESLRQSL---------MKLERP-RTSKG 702

  Fly   674 YRTPKV-----SASLQAVLAQAMQ 692
            ...||.     ||..:.|:...:|
Human   703 KARPKTGRRKRSAKPETVIDSLLQ 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	193/337 (57%)
		Smc	<431..>580	CDD:440809	49/154 (32%)
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	191/332 (58%)
		Smc	<451..>615	CDD:440809	48/163 (29%)