DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp68D and KIF1C

DIOPT Version :10

Sequence 1:NP_524029.2 Gene:Klp68D / 39332 FlyBaseID:FBgn0004381 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_006603.2 Gene:KIF1C / 10749 HGNCID:6317 Length:1103 Species:Homo sapiens


Alignment Length:953 Identity:273/953 - (28%)
Similarity:421/953 - (44%) Gaps:239/953 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVD--GNKEQRKVFTYDAAY--------D 74
            |:|.||.||.:.||.|:.:..||::..|     ..::::  .:|:..|.||:|.:|        .
Human     6 VKVAVRVRPFNARETSQDAKCVVSMQGN-----TTSIINPKQSKDAPKSFTFDYSYWSHTSTEDP 65

  Fly    75 ASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLH 139
            ..|:|..:|.::...::....||:|.|||||||||.||::||.| |......||:|:..|.::..
Human    66 QFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMG-RQEPGQQGIVPQLCEDLFSR 129

  Fly   140 I--NRTENFQFLVDVSYLEIYMEELRDLLKPNSK-HLEVRERG-SGVYVPNLHAINCKSVEDMIK 200
            :  |::....:.|:|||:|||.|.:||||.|.|: .|.|||.. .|.||.:|..:...|..|:..
Human   130 VSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIAD 194

  Fly   201 VMQVGNKNRTVGFTNMNEHSSRSHAIFMIKI-EMCD---TETNTIKVGKLNLIDLAGSERQSKTG 261
            :|..|||.|||..|||||.||||||:|.|.. :.|.   |..::.||.|::|:|||||||...:|
Human   195 LMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSG 259

  Fly   262 ASAERLKEASKINLALSSLGNVISALAE------SSPHVPYRDSKLTRLLQDSLGGNSKTIMIAN 320
            |...||||.:.||.:|::||.||||||:      .|..:|||||.||.||:::|||||:|.|||.
Human   260 ARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAA 324

  Fly   321 IGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRS---- 381
            :.|::.||.|||:|||||.|.|.|:...|.||||....::|.|||:.||:.|:..|....|    
Human   325 LSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASALEG 389

  Fly   382 ----EKQVTAKKQRVKKP-------KKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENE 435
                |..|......|..|       ...|...|:..|...:|     |....||.| .|..:|.|
Human   390 LKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNT-----ESQIGPEEA-MERLQETE 448

  Fly   436 AEVAKSNEELERE-------RVENSKLAAKLAELEGQLVRGGKNLLDTYS-----------ERQI 482
            ..:|:.||..|.:       |:|...|.|::    |..||.....:..:|           |..:
Human   449 KIIAELNETWEEKLRKTEALRMEREALLAEM----GVAVREDGGTVGVFSPKKTPHLVNLNEDPL 509

  Fly   483 ELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERN--------------VSLE---------- 523
            ..|..|..|.:...|..::...::|   |...|||::              |:||          
Human   510 MSECLLYHIKDGVTRVGQVDMDIKL---TGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVN 571

  Fly   524 -----------------------------QEVELKKRK------------LSKCYAKYLALQQEL 547
                                         ::..|::.:            :...:|:...|:|:.
Human   572 GKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQG 636

  Fly   548 NDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEE------QEEWK- 605
            .|.|.:..:.|::||   |:..||.:...|:::       :||||..:...::      :|.|: 
Human   637 IDIKLEMEKRLQDLE---NQYRKEKEEADLLLE-------QQRLYADSDSGDDSDKRSCEESWRL 691

  Fly   606 FSSMSLPTPP------------GGDGKFSSKRPVSH-PQRRRPTSEYALQ--EAKSNSPSSLRFK 655
            .||:....||            ...||..:.|.|.. |||||      ||  :.:..:.:.|:.:
Human   692 ISSLREQLPPTTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRR------LQGKDPRWATMADLKMQ 750

  Fly   656 SENIVNYELEMPCRTTQEYRTPKVSASLQAVLAQAM----QTGGDDIDIVDSHTNSLRSRLENI- 715
            :...:.||:.:     .::|..:  |.::|:.|..|    :|.|..    |...::.|:...:: 
Human   751 AVKEICYEVAL-----ADFRHGR--AEIEALAALKMRELCRTYGKP----DGPGDAWRAVARDVW 804

  Fly   716 --INANANGGAGPGAGV---AVGSSIPNV------------------------------RNIKSS 745
              :.....||||.|.|.   |.|:.:.::                              |.::..
Human   805 DTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRME 869

  Fly   746 RGLPSAASNLDSNRR-------PPTGRLPAKK--PASAYPKAR 779
            |.:|.|..:.|.|..       ||.|...|::  |:...|.||
Human   870 RVIPLAQDHEDENEEGGEVPWAPPEGSEAAEEAAPSDRMPSAR 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp68DNP_524029.2 KISc 20..351 CDD:214526 152/354 (43%)
Smc <431..>580 CDD:440809 40/231 (17%)
KIF1CNP_006603.2 KISc_KIF1A_KIF1B 4..355 CDD:276816 152/354 (43%)
Kinesin_assoc 352..522 CDD:465047 45/179 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 400..438 7/42 (17%)
FHA_KIF1C 498..599 CDD:438780 13/103 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 808..828 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 874..924 11/39 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 950..1103
Blue background indicates that the domain is not in the aligned region.

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