Protein Alignment Klp68D and CENPE

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001804.2
• Gene: CENPE / 1062
• HGNCID: 1856
• Length: 2701
• Species: Homo sapiens
• Alignment Length: 761
• Identity: 230/761 - (30%)
• Similarity: 366/761 - (48%)
• Gaps: 152/761 - (19%)

  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVY---PNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTT 81
            |.|.||.||:::||  |...|...||   .|..:.:    |||:|.    |.:|..:..:.|...
Human     7 VAVCVRVRPLNSRE--ESLGETAQVYWKTDNNVIYQ----VDGSKS----FNFDRVFHGNETTKN 61

  Fly    82 LYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINRTENF 146
            :|.|:..|::.|.::|:||.|||||||.:|||:||   .|:::.:|:|||....|:..|.:..:.
Human    62 VYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTM---MGSEDHLGVIPRAIHDIFQKIKKFPDR 123

  Fly   147 QFLVDVSYLEIYMEELRDLL--KPNSKHLEVRER-GSGVYVPNLHAINCKSVEDMIKVMQVGNKN 208
            :||:.|||:|||.|.:.|||  ....|.|.:||. ...|||.:|......:.|..:|.:..|.|:
Human   124 EFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKS 188

  Fly   209 RTVGFTNMNEHSSRSHAIFMIKIEM--------CDTETNTIKVGKLNLIDLAGSERQSKTGASAE 265
            |..|.|.||:.|||||.||.:.:|.        |:   .::||..|||:|||||||.::|||:..
Human   189 RHYGETKMNQRSSRSHTIFRMILESREKGEPSNCE---GSVKVSHLNLVDLAGSERAAQTGAAGV 250

  Fly   266 RLKEASKINLALSSLGNVISALAES--SPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNY 328
            ||||...||.:|..||.||..|::.  ...:.||||||||:||:|||||:||.:|..|.|  .::
Human   251 RLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITP--VSF 313

  Fly   329 NETLTTLRYASRAKSIQNQPIKNE-DPQDAKLKEYQEEIERLKRLIG----PQQQQRSEK----Q 384
            :||||.|::||.||.::|.|..|| ...:|.||.|::||..||:.:.    ..:.|..||    |
Human   314 DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQ 378

  Fly   385 VTAKK---QRVKKPKKETVTKEM--SDSLQVSTIEQPVEDDSDPEGAESESDKENEAE--VAKSN 442
            :..:|   |:|:..|.|.:|:.:  |.||   |::|           |.::.::....  :.|.|
Human   379 LLEEKDLLQKVQNEKIENLTRMLVTSSSL---TLQQ-----------ELKAKRKRRVTWCLGKIN 429

  Fly   443 EELERERVENSKLA----------AKLAELEGQLVRG-----------GKNLLDTYSE------- 479
                  :::||..|          .|..:|...|:|.           ..|.|||.||
Human   430 ------KMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPAT 488

  Fly   480 ---RQIELEKKLVEI-AERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKY 540
               .|..:|.:|..: |:.....::.:|....:||..|:::|:| .|: |.|..:||..|  .:.
Human   489 KLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKN-DLD-EFEALERKTKK--DQE 549

  Fly   541 LALQQELNDCKS------DHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDE 599
            :.|..|:::.|:      .:||||.....::.||::|.:.|:..:..::..:..:.:.....|..
Human   550 MQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL 614

  Fly   600 EQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPT---SEYALQEAKSNSPSSLRFKSENIVN 661
            |.                         :..|::.:.|   :|....:||..|..   .:|||:..
Human   615 ES-------------------------IEDPKQMKQTLFDAETVALDAKRESAF---LRSENLEL 651

  Fly   662 YELEMPCRTT--------QEYRTP-KVSASLQAVLAQAMQTGGDDI 698
            .|......||        |.|::. :....:|..|.:.:|:..::|
Human   652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEI 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	142/346 (41%)
		Smc	<431..>580	CDD:440809	42/188 (22%)
CENPE	NP_001804.2	KISc_CENP_E	6..329	CDD:276825	140/339 (41%)
		SMC_prok_B	345..1131	CDD:274008	85/405 (21%)
		SMC_prok_B	828..1715	CDD:274008
		SMC_prok_B	1332..2129	CDD:274008
		SMC_N	1730..>2573	CDD:481474
		Kinetochore-binding domain	2126..2476
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2355..2376
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2508..2533
		Globular autoinhibitory domain. /evidence=ECO:0000250	2510..2698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2588..2701