Protein Alignment Klp68D and KIF20A

DIOPT Version :10

• Sequence 1: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_005724.1
• Gene: KIF20A / 10112
• HGNCID: 9787
• Length: 890
• Species: Homo sapiens
• Alignment Length: 927
• Identity: 221/927 - (23%)
• Similarity: 365/927 - (39%)
• Gaps: 304/927 - (32%)

  Fly    13 SQTPNECVQVVVRCRPM--SNRERSERSPEVVNVYPNRGVVELQN----VVDGNKE-------QR 64
            |:...|.|:|.:|.||:  |..||.|          ::|.|.::|    |:...|:       :|
Human    58 SEDSMEKVKVYLRVRPLLPSELERQE----------DQGCVRIENVETLVLQAPKDSFALKSNER 112

  Fly    65 KV------FTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGND 123
            .:      ||:...:.....|.:.::..|..:|..||:|.|..|:.||.|.:|||.|::|...:.
Human   113 GIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIKDG 177

  Fly   124 ELMGIIPRTF-----------------------EQIWL---HINRTE------------------ 144
               ||:||:.                       |.|||   .|.:.|
Human   178 ---GILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGGLQEEELST 239

  Fly   145 --------------------------------------------------------NFQFLVDVS 153
                                                                    |.:|.:.:|
Human   240 SLKRSVYIESRIGTSTSFDSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLPVPANIRFSIWIS 304

  Fly   154 YLEIYMEELRDLLKPNSKHLE------VRERGSGVYVPNLHAINCKSVEDMIKVMQVGNKNRTVG 212
            :.|||.|.|.|||:|.|:..:      ..::....||.:|:.|:.:..|:..|:::||.||::..
Human   305 FFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFA 369

  Fly   213 FTNMNEHSSRSHAIFMIKIEMCDTETNTI-KVGKLNLIDLAGSERQSKTGASAERLKEASKINLA 276
            .|::|::|||||:||.|:|.....|.:.: |:.:|:|.||||||| .|...|.||||||..||.:
Human   370 STHLNQNSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSER-CKDQKSGERLKEAGNINTS 433

  Fly   277 LSSLGNVISALAESSPH------VPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTTL 335
            |.:||..|:||.::..:      ||:|||||||:.|....|..::.||.|:.|....|:|||...
Human   434 LHTLGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVA 498

  Fly   336 RYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVKKPKKETV 400
            ::::.|..:.:.|                          |.|              :..|...:.
Human   499 KFSAIASQLVHAP--------------------------PMQ--------------LGFPSLHSF 523

  Fly   401 TKEMSDSLQVS-TIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERERVENSKLAAKLAELEG 464
            .||  .||||| ::|:..:.|:.     .:.|.||||:::...:|                ||.
Human   524 IKE--HSLQVSPSLEKGAKADTG-----LDDDIENEADISMYGKE----------------ELL- 564

  Fly   465 QLVRGGKNLLDTYSERQIELEKKLVE------IAERKKREIEIQQQLELQEETTLEIRERNVSL- 522
            |:|...|.||....:.:::||..|.:      :.:.::||....:.|:.|:|...|:.|..:::
Human   565 QVVEAMKTLLLKERQEKLQLEMHLRDEICNEMVEQMQQREQWCSEHLDTQKELLEEMYEEKLNIL 629

  Fly   523 --------EQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNE-LVKELKRQLLI 578
                    ::|::.:..|:.:..    ||.||.......|.|...||.:.::: |......|.|
Human   630 KESLTSFYQEEIQERDEKIEELE----ALLQEARQQSVAHQQSGSELALRRSQRLAASASTQQL- 689

  Fly   579 IDNFVPIEVKQRL-YTQAKYDEEQEE-WKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSEYAL 641
                  .|||.:| ..:|:.:...|| .|:..|..|.|        |.:|.:....::      |
Human   690 ------QEVKAKLQQCKAELNSTTEELHKYQKMLEPPP--------SAKPFTIDVDKK------L 734

  Fly   642 QEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAV------------LAQAMQTG 694
            :|.:.|.         .::..||:            |:..|||:.            |.||:.|
Human   735 EEGQKNI---------RLLRTELQ------------KLGESLQSAERACCHSTGAGKLRQALTT- 777

  Fly   695 GDDIDIVDSHTNSLRSRLEN---IINANANGGAGPGAGVAVGSSIPNVRNIKSSRGLPSAASNLD 756
            .|||.|....|   .:.|:|   ::..:....|   |.:|     .....:...:|..||...|.
Human   778 CDDILIKQDQT---LAELQNNMVLVKLDLRKKA---ACIA-----EQYHTVLKLQGQVSAKKRLG 831

  Fly   757 SNR--RPPTGRLPAKKP 771
            :|:  :.|..:.|.|||
Human   832 TNQENQQPNQQPPGKKP 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	125/462 (27%)
		Smc	<431..>580	CDD:440809	36/164 (22%)
KIF20A	NP_005724.1	KISc_KIF23_like	63..505	CDD:276819	124/455 (27%)
		SMC_prok_B	<547..>795	CDD:274008	68/314 (22%)
		RBD_KIF20A	602..657	CDD:409645	11/58 (19%)
		Globular. /evidence=ECO:0000255	763..890		24/98 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	832..865		6/17 (35%)