DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp68D and kif3b

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_004918676.1	Gene:	kif3b / 100494561	XenbaseID:	XB-GENE-979232	Length:	744	Species:	Xenopus tropicalis

Alignment Length:	817	Identity:	370/817 - (45%)
Similarity:	507/817 - (62%)	Gaps:	118/817 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDAS 76
            |....:|.|:||||||||:::|.:.....||:|....|.|.::.......|..|.||:||.||::
Frog     2 SKSKSSESVRVVVRCRPMNSKELAAGYERVVDVDVKLGQVAVKVHKGAANELPKTFTFDAVYDSN 66

  Fly    77 ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHIN 141
            :.|..||.|...|||.|||.||||.||||||||||||:||||||.:.|..|:||.:||.|:.||:
Frog    67 SKQVELYDETFRPLVDSVLLGFNGTIFAYGQTGTGKTYTMEGVRIDPEKRGVIPNSFEHIFTHIS 131

  Fly   142 RTENFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRER-GSGVYVPNLHAINCKSVEDMIKVMQV 204
            |::|.|:||..||||||.||:|||| |..||.||::|| .:||||.:|.:...|||:::..||.|
Frog   132 RSQNQQYLVRASYLEIYQEEIRDLLSKDQSKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNV 196

  Fly   205 GNKNRTVGFTNMNEHSSRSHAIFMIKIEMC-----DTETNTIKVGKLNLIDLAGSERQSKTGASA 264
            ||:||:||.||||||||||||||||.|| |     |.| |.|:||||||:||||||||:||||..
Frog   197 GNQNRSVGATNMNEHSSRSHAIFMITIE-CSQIGLDGE-NHIRVGKLNLVDLAGSERQTKTGAQG 259

  Fly   265 ERLKEASKINLALSSLGNVISALAES-SPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNY 328
            ||||||:||||:||:||||||||.:. |.|:||||||||||||||||||:||:|:|||||::||.
Frog   260 ERLKEATKINLSLSALGNVISALVDGRSTHIPYRDSKLTRLLQDSLGGNAKTVMVANIGPASYNV 324

  Fly   329 NETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVTAKKQRVK 393
            .||||||||::|||:|:|:|..||||:||.|:|:||||.|||..:        ||:|..|::|
Frog   325 EETLTTLRYSNRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQL--------EKRVGVKRRR-- 379

  Fly   394 KPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDK------------------ENEA---- 436
            :.::.|...|             ||.|.|.||...|.|.                  |.:|
Frog   380 RGRRRTPGGE-------------VEGDEDEEGDLYEGDDVLEDKEDYWREQQERLEIEKKAILED 431

  Fly   437 -------------EVAKSNEELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKKL 488
                         |..|..::|:|||.....|:||:..:|.:|:.||||::|..:|:|..||:|.
Frog   432 HSLVAEEKLKLLKEQEKKMDDLKREREAMEMLSAKVKAMESKLLVGGKNIVDHTNEQQKVLEQKR 496

  Fly   489 VEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSD 553
            .||||:|.||.|||||:|.::|.|||::|...||:|||::|.:||.|.::|..|::.|::|.:.:
Frog   497 HEIAEQKCREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEE 561

  Fly   554 HNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGD 618
            |.::.:|||..||||.:|||.:.|||:||:|:|.|.::..:..:|||:::||..::|..     |
Frog   562 HIKERQELEQTQNELTRELKLKHLIIENFIPLEEKNKMMNRCYFDEEEDQWKLHAISRL-----D 621

  Fly   619 GKFSSKRPVSHPQRRRPTSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASL 683
            .:...:||||....:||..::|.........|  |:::||||..||:||.|||::|..|.::..:
Frog   622 NQQMMRRPVSAIGYKRPLCQHAKMSMMVRPDS--RYRAENIVLLELDMPSRTTRDYEGPAIAPKV 684

  Fly   684 QAVLAQAMQTGGDDIDI-VDSHTNSLRSRLENIINANANGGAGPGAGVAVGSSIPNVRNIKSSRG 747
            ||.|..|:|   |:.|| ||:.|          .::.|                     ||.::.
Frog   685 QAALEAALQ---DEDDIQVDAST----------FDSTA---------------------IKRTKA 715

  Fly   748 LPSAASNLDSNRRPPTGRLPAKKPASAYPKARGLVNK 784
            .|.      |:|||  |...:...:..:|::||||.|
Frog   716 RPK------SSRRP--GANGSSSGSPLFPQSRGLVPK 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	208/333 (62%)
		KISc	20..351	CDD:214526	210/338 (62%)
		GBP_C	<479..576	CDD:303769	47/96 (49%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
kif3b	XP_004918676.1	KISc_KIF3	8..340	CDD:276822	208/333 (62%)
kif3b	XP_004918676.1	Smc	<352..630	CDD:224117	107/305 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55849
Inparanoid	1	1.050	600	1.000	Inparanoid score	I947
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0002745
OrthoInspector	1	1.000	-	-		oto103447
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160