DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp68D and kif3c

DIOPT Version :9

Sequence 1:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_002661420.3	Gene:	kif3c / 100333558	-ID:	-	Length:	754	Species:	Danio rerio

Alignment Length:	739	Identity:	345/739 - (46%)
Similarity:	474/739 - (64%)	Gaps:	62/739 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKSRRPGTGSSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRK 65
            ||.||:   ||      |.|:|||||||::.:|.|.....:|.:....|.|.|:|...|..:..|
Zfish     1 MSMKSK---TG------ESVKVVVRCRPLNRKEESSGYENIVQMDVKLGQVALRNAKAGPGDLLK 56

  Fly    66 VFTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIP 130
            .||:||.||..:.|..||.|.|.||:.|||.||||.||||||||||||:||:|...:.|..||||
Zfish    57 TFTFDAVYDECSKQGDLYDETVRPLIDSVLRGFNGTIFAYGQTGTGKTYTMQGQWLDAERRGIIP 121

  Fly   131 RTFEQIWLHINRTENFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRERG-SGVYVPNLHAINCK 193
            .:||.|:.||:|::|.|:||..||||||.||:|||| |.:||.||::|.. ||||:.:|.:...|
Zfish   122 NSFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLTKDHSKKLELKESADSGVYIKDLSSFVTK 186

  Fly   194 SVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCD----TETNTIKVGKLNLIDLAGS 254
            :|:::..||.|||:.|:|||||||||||||||||:|.:| |.    ...|.|:||||||:|||||
Zfish   187 NVKEIEHVMNVGNQTRSVGFTNMNEHSSRSHAIFIITVE-CSQLGPDGQNHIRVGKLNLVDLAGS 250

  Fly   255 ERQSKTGASAERLKEASKINLALSSLGNVISALAES-SPHVPYRDSKLTRLLQDSLGGNSKTIMI 318
            |||:|||...||||||:||||:||:||||||||.:. |.||||||||||||||||||||:||||:
Zfish   251 ERQTKTGVQGERLKEATKINLSLSALGNVISALVDGRSSHVPYRDSKLTRLLQDSLGGNAKTIMV 315

  Fly   319 ANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEK 383
            |.:||::|||.|||||||||:|||:|:|:|..||||:||.|:|:||||.|||..:..:......|
Zfish   316 ATLGPASYNYEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLDKRGMLTKRK 380

  Fly   384 QVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEEL--- 445
            :   :.:|::|..:|.|.:|  |.|:....|:.||.::.....|.:.:.|.|.|..:.:..|
Zfish   381 R---RSRRLRKIGEEEVEEE--DDLEDYDDEEIVEKEAQEYMKEQQEELEREKEAIRDDHSLVAE 440

  Fly   446 ERERVENSK----------------LAAKLAELEGQLVRGGKNLLDTYSERQIELEKKLVEIAER 494
            |::|:...|                |.||...:|.:|:.||||::|..:|:|..||:|..||||:
Zfish   441 EKQRLLEEKERMMRHLKKEQEATEMLTAKFKAMESKLLVGGKNIIDHTNEQQKMLEQKRHEIAEQ 505

  Fly   495 KKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLR 559
            .:||.||||||..|:|.|||:||...||:||||.|.:||.|.|||..:|:.::.|...:|.:..:
Zfish   506 TRREREIQQQLLDQDEETLELRETFSSLQQEVEAKTKKLKKLYAKLQSLKADIQDVNDEHVRSRQ 570

  Fly   560 ELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFS-- 622
            :||..||||.:|||.:.|||:||:|.|.|.::..:.::|.|:::|||.    |..| .:.||:
Zfish   571 DLEQTQNELTRELKFKYLIIENFIPPEEKNKIMNRLEFDAEEDQWKFQ----PLVP-AENKFTQM 630

  Fly   623 SKRPVSHPQRRRPTSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVL 687
            .:||.|....:||.|:||.......:.|  |:::|||:..||:|         ||.|...|:...
Zfish   631 KRRPASAVGYKRPISQYARVAMAMGAHS--RYRAENIMLLELDM---------TPPVVFQLELQK 684

  Fly   688 AQAMQTGGDDIDIVDSHTNSLRSR 711
            :.:.:....|: ::|:  ||.|.:
Zfish   685 SGSEEEPSRDV-LLDN--NSYREK 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	201/332 (61%)
		KISc	20..351	CDD:214526	203/337 (60%)
		GBP_C	<479..576	CDD:303769	49/96 (51%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
kif3c	XP_002661420.3	KISc_KIF3	9..341	CDD:276822	201/332 (61%)
kif3c	XP_002661420.3	SMC_N	<411..>584	CDD:330553	65/172 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580427
Domainoid	1	1.000	213	1.000	Domainoid score	I2697
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	587	1.000	Inparanoid score	I956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0002745
OrthoInspector	1	1.000	-	-		otm26374
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2170
SonicParanoid	1	1.000	-	-		X1829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790