DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10907 and Cwc27

DIOPT Version :9

Sequence 1:	NP_648508.1	Gene:	CG10907 / 39331	FlyBaseID:	FBgn0036207	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001347023.1	Gene:	Cwc27 / 67285	MGIID:	1914535	Length:	472	Species:	Mus musculus

Alignment Length:	502	Identity:	239/502 - (47%)
Similarity:	314/502 - (62%)	Gaps:	58/502 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSNIYIQEPPTSGKVLLKTTVGDIDIELWARECPKACRNFVQLCLEGYYKNTEFHRLVKGFIVQG 65
            |||||||||||:||||||||.||||||||::|.|||||||:|||||.||.||.|||:|.||||||
Mouse     1 MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQG 65

  Fly    66 GDPNGDGTGGESIYGQPFKDEFHSRLRYTRRGLVGMANSGKDDNGSQFFFTFAPTPELQNKNTLF 130
            |||.|.|||||||||.|||||||||||:.|||||.|||:|..|||||||||.....||.||:|:|
Mouse    66 GDPTGTGTGGESIYGAPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIF 130

  Fly   131 GKITGDTIYNMLKLEDGIVDHQERPMHAHRIVSTEVLSNPFDDIVPRILSQPSTKSKKTKKE--- 192
            ||:||||:||||:|.:..:|.:|||.:.|||.|.|||.||||||.||.:.:|  |::|.::|
Mouse   131 GKVTGDTVYNMLRLTEVDIDDEERPRNPHRIKSCEVLFNPFDDITPREIKKP--KNEKPEEEVKK 193

  Fly   193 --RQGVKNFGLLSFGEEAEGDEEETNVYVKQNAGKAKSLHD-VTDDPKLSKEPIRVPKVEK---- 250
              .:|.|||.|||||||||.:|||.|...:...|::||.|| :.|||.||.    ||.||.
Mouse   194 LKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGRSKSSHDLLKDDPHLSS----VPAVESEKDD 254

  Fly   251 --ADIEEHLSDDCPEDSVKDKPSTASSD---LIKMKLSKRSKSGADKKVQPVEEKSDSEDDEDVL 310
              .|:|:.|.|.  ||...::......|   |::.:::||.|..|...|:      .:.|.|...
Mouse   255 ATGDLEDLLQDG--EDDSAERDEYMEDDEKNLMRERIAKRLKKDASASVK------SAGDGEKKP 311

  Fly   311 LTREEEQSRKVSEEKSKIREEIASLKKQYQMDKQSKDKLVNGQEKAAKSNEIKGSSENHYINDFI 375
            .:|.||           :|:|...||::....||.|:..:    |..:..|.:.::.:..:.::.
Mouse   312 ASRSEE-----------LRKEARQLKRELLAAKQKKETAI----KVEEGREEEEAAPDGAVAEYR 361

  Fly   376 ESKEKYTAKVKLQP-KGQSREAFTLSLLSKFRTKLDNLKQKSSSDDGESEPKDIDDRVVEQEIIG 439
            ..|:||.|..|.|| ||.|||..||:|||:|::||.           ::..:..::.|.|.|:..
Mouse   362 REKQKYEALRKQQPKKGTSREDQTLALLSQFKSKLT-----------QAITETPENSVPEAEVED 415

  Fly   440 DD-WLSHTLNFNSTTPVLAKDANKKGDDWYDAYDPRNPLNKRKRGET 485
            |: |:||.|.|...|..: |||:.:..|.::.||||||:|||:|.|:
Mouse   416 DEGWMSHVLQFEDKTRKV-KDASMQDSDTFEIYDPRNPVNKRRREES 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10907	NP_648508.1	cyclophilin_CeCYP16-like	8..178	CDD:238906	124/169 (73%)
Cwc27	NP_001347023.1	cyclophilin_CeCYP16-like	8..178	CDD:238906	124/169 (73%)
Cwc27	NP_001347023.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..472		15/32 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849371
Domainoid	1	1.000	236	1.000	Domainoid score	I2335
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21192
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1830
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48670
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	1	1.000	-	-		FOG0005686
OrthoInspector	1	1.000	-	-		oto92909
orthoMCL	1	0.900	-	-		OOG6_102804
Panther	1	1.100	-	-	LDO	PTHR45625
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3553
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770