DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10907 and NKTR

DIOPT Version :9

Sequence 1:	NP_648508.1	Gene:	CG10907 / 39331	FlyBaseID:	FBgn0036207	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001336053.1	Gene:	NKTR / 4820	HGNCID:	7833	Length:	1463	Species:	Homo sapiens

Alignment Length:	603	Identity:	159/603 - (26%)
Similarity:	231/603 - (38%)	Gaps:	189/603 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VGDIDIELWARECPKACRNFVQLCL--EGY---------YKNTEFHRLVKGFIVQGGD-PNGDGT 73
            ||.|..:|::..|||.|:||:.||.  :|.         ||.:.|||:||.|::|||| ..|:|.
Human    20 VGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGK 84

  Fly    74 GGESIYGQPFKDEFHSRLRYTRRGLVGMANSGKDDNGSQFFFTFAPTPELQNKNTLFG-KITGDT 137
            |||||||..|||| :..|::.|..|:.|||.||..||||||.|..|.|.|...:.:|| .|:|..
Human    85 GGESIYGGYFKDE-NFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDGVHVVFGLVISGFE 148

  Fly   138 IYNMLKLEDGIVDHQERPMHAHRIVSTEVL-SNPFDDIVPRILSQPS------------------ 183
            :..  ::|:...|...||....|::...|| :....|:..:...:|:
Human   149 VIE--QIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESS 211

  Fly   184 ------------------TKSKKTKKERQGVKNFGLLSFGEEAEGDEEETNVYVKQNAGKAK--- 227
                              .|.|::||.|            :||...||..|.:.....|.::
Human   212 SESELEHERSRRRKHKRRPKVKRSKKRR------------KEASSSEEPRNKHAMNPKGHSERSD 264

  Fly   228 --SLHDVTDDPKLSKEPIR------VPK----------VEKADIEEHLSDDCPEDSVKD-KPSTA 273
              ....|....|..|..:|      ||:          |..|:.|..:.|..|  .|.| |||.:
Human   265 TNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAP--IVSDQKPSVS 327

  Fly   274 SSDLIKMKLSKRSKSGADKKVQPVEEKSDSE-DDEDVLLT----REEEQS----RKVSEEK---- 325
            .|.   .|:..|   |..:...|...:|.|| ||:|...|    :||.|.    |..|.||
Human   328 KSG---RKIKGR---GTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKG 386

  Fly   326 SKIREEIASLKKQYQMDKQSKDKLVNG------------------QEKAAKSNEIKGSSENH--- 369
            .|:.:..:|...:..:.::|:....||                  :||..|..: ||..:.|
Human   387 DKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKK-KGKKQKHCRR 450

  Fly   370 ---------YINDFIESKEKYTAKVKLQPKGQSREAFTLSLLSKFRTKLDNLKQKSSSDDGESEP 425
                     .|...|||.:..|.::| ....:.|.:.:.||.|...:|.|    .|.||
Human   451 HKQTKKRRILIPSDIESSKSSTRRMK-SSCDRERSSRSSSLSSHHSSKRD----WSKSD------ 504

  Fly   426 KDIDDRVVEQEIIGDDWLSHTLNFNSTTPVLAKDANKKGDDWYDAYDPRNPLNKRKRGETGS--- 487
            ||:...           |:|:..                    |:|..::......||.:.|
Human   505 KDVQSS-----------LTHSSR--------------------DSYRSKSHSQSYSRGSSRSRTA 538

  Fly   488 SKSSS-----GKSKSSKR 500
            |||||     .||:||.:
Human   539 SKSSSHSRSRSKSRSSSK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10907	NP_648508.1	cyclophilin_CeCYP16-like	8..178	CDD:238906	68/170 (40%)
NKTR	NP_001336053.1	cyclophilin	7..174	CDD:320812	65/156 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..591		91/433 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..627
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..1072
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1169..1215
		Arg/Ser tandem repeat-rich	1311..1348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810