DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10907 and nktr

DIOPT Version :9

Sequence 1:	NP_648508.1	Gene:	CG10907 / 39331	FlyBaseID:	FBgn0036207	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_001338072.4	Gene:	nktr / 323005	ZFINID:	ZDB-GENE-030131-1725	Length:	1396	Species:	Danio rerio

Alignment Length:	608	Identity:	150/608 - (24%)
Similarity:	245/608 - (40%)	Gaps:	155/608 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VGDIDIELWARECPKACRNFVQLCL--EG---------YYKNTEFHRLVKGFIVQGGD-PNGDGT 73
            ||.|..:|::..|||..:||:.||.  :|         .||.:.|||:||.|::|||| ..|:|.
Zfish    20 VGRIVFQLFSDICPKTSKNFLCLCTGEKGSGKATGKKLCYKGSTFHRVVKNFMIQGGDFTEGNGR 84

  Fly    74 GGESIYGQPFKDEFHSRLRYTRRGLVGMANSGKDDNGSQFFFTFAPTPELQNKNTLFGKITGDTI 138
            |||||:|..|:|| :..|::.|..|:.|||.|||.||||||.|....|.|...:.:||.:...
Zfish    85 GGESIFGGFFEDE-NFTLKHDRAFLLSMANRGKDTNGSQFFITTKTAPHLDGVHVVFGLVISG-- 146

  Fly   139 YNMLKLEDGI-VDHQERPMHAHRIVST-EVLSNPFDDIVPRIL---------SQPSTKS------ 186
            :.::|..:|: .|...||....|::.. ::::...:|::...|         ||.|::|
Zfish   147 FEVIKNIEGLKTDSASRPYADVRVIDCGQLITKSANDVLQGKLRKAFYSEDDSQSSSESLSEHSS 211

  Fly   187 -----------------------KKTKKERQGVKNFGLLSFGEEAEGD-EEETNVYVKQNAGKAK 227
                                   ::.||:|:.||..|..|   .|||: .||.:...:||..:.|
Zfish   212 LEEEPTSRKRKKSSKSKHAKRSRREAKKDRETVKTAGPAS---HAEGEMAEENDGEAEQNVKREK 273

  Fly   228 SLHDVTDDPKLSKEPI----RVPKVEKA---DIEEHLSDDCPEDSVKDKPSTASS-------DLI 278
            .:....:.|.:.:...    .:|..|:|   |:::  :|..|.|:   ||:...|       ..:
Zfish   274 PVVRPEEIPPVPENRFLLRRDMPTQEEAIKIDVQD--TDIVPNDT---KPAVTKSGRKIKGRGTM 333

  Fly   279 KMKLSKRSKSGAD---------------------KKVQP--VEEKSDSE---DDEDVLLTREEEQ 317
            :.....||||.::                     |..||  ||..|..|   |..|...:|.|.:
Zfish   334 RYHTPPRSKSRSESECERGSSETPPHWKEEMQRTKAYQPPSVERWSKEERWDDRSDTPRSRSESR 398

  Fly   318 SRKVSE------------EKSKIREEIASLK----KQYQMDKQSKDKLVNGQEKAAKSNEIKGSS 366
            ...:.|            ||.|.:::..|.|    |:::..|..:..|.:|:...:.....|.||
Zfish   399 EHSLGEASVYSSQHRSKKEKKKAKQKKKSKKRKHAKKHKKTKTKETSLTDGEVSVSSGKRTKHSS 463

  Fly   367 --ENHYINDFIESKEKYTAKVKLQPKGQSREAFTLSLLSKFRTKLDNLKQKS-SSDDGESEPKDI 428
              |......:..|..:::.:   ..|.:|.....||..|:........:.:| |..|..||.:..
Zfish   464 RAERRRSRSYSRSSSRHSHR---SYKSESERRHYLSSSSRDSRSYSRSRSRSYSRSDSRSERRAR 525

  Fly   429 DDRVVEQEIIGDDWLSHTLN-----------------FNSTTPVLAKDANKKGDDWYDAYDPRNP 476
            ..:...:...|.. ::|:.:                 ::|.||..:|..|          :.|:|
Zfish   526 SSKRSSRSRSGRS-VTHSRSRSRSRYRTRSRTRSNSRYSSETPTRSKKRN----------ELRSP 579

  Fly   477 LNKRKRGETGSSKSSSGKSKSSK 499
             .|.|..|.|.|:......||.|
Zfish   580 -RKSKPTEGGISRLDKSVPKSIK 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10907	NP_648508.1	cyclophilin_CeCYP16-like	8..178	CDD:238906	62/170 (36%)
nktr	XP_001338072.4	cyclophilin	7..174	CDD:294131	61/156 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810