Protein Alignment CG10907 and CWC27

DIOPT Version :10

• Sequence 1: NP_648508.1
• Gene: CG10907 / 39331
• FlyBaseID: FBgn0036207
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_005860.2
• Gene: CWC27 / 10283
• HGNCID: 10664
• Length: 472
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 234/498 - (46%)
• Similarity: 310/498 - (62%)
• Gaps: 50/498 - (10%)

  Fly     1 MSNIYIQEPPTSGKVLLKTTVGDIDIELWARECPKACRNFVQLCLEGYYKNTEFHRLVKGFIVQG 65
            |||||||||||:||||||||.||||||||::|.|||||||:|||||.||.||.|||:|.||||||
Human     1 MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQG 65

  Fly    66 GDPNGDGTGGESIYGQPFKDEFHSRLRYTRRGLVGMANSGKDDNGSQFFFTFAPTPELQNKNTLF 130
            |||.|.|:|||||||.|||||||||||:.|||||.|||:|..|||||||||.....||.||:|:|
Human    66 GDPTGTGSGGESIYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLGRADELNNKHTIF 130

  Fly   131 GKITGDTIYNMLKLEDGIVDHQERPMHAHRIVSTEVLSNPFDDIVPRIL-----SQPSTKSKKTK 190
            ||:||||:||||:|.:..:|..|||.:.|:|.|.|||.||||||:||.:     .:|..:.||.|
Human   131 GKVTGDTVYNMLRLSEVDIDDDERPHNPHKIKSCEVLFNPFDDIIPREIKRLKKEKPEEEVKKLK 195

  Fly   191 KERQGVKNFGLLSFGEEAEGDEEETNVYVKQNAGKAKSLHD-VTDDPKLSKEPIRVPKVEKADIE 254
            .  :|.|||.|||||||||.:|||.|...:...||:||.|| :.|||.||..|  |.:.||.|..
Human   196 P--KGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVP--VVESEKGDAP 256

  Fly   255 EHLSDDCPEDSVKDKPSTA-SSDLIKMKLSKRSKSGADKKVQ-----PVEEKSDSEDDEDVLLTR 313
            :.:.|...|.:..|:.... ..:|::.:::|:.|......|:     .||:||.|..:|
Human   257 DLVDDGEDESAEHDEYIDGDEKNLMRERIAKKLKKDTSANVKSAGEGEVEKKSVSRSEE------ 315

  Fly   314 EEEQSRKVSEEKSKIREEIASLKKQYQMDKQSKDKLVNGQEKAAKSNEIKGSSENHYINDFIESK 378
                          :|:|...||::....||.  |:.|..::|.|.:|.:.:..:..:.::...|
Human   316 --------------LRKEARQLKRELLAAKQK--KVENAAKQAEKRSEEEEAPPDGAVAEYRREK 364

  Fly   379 EKYTAKVKLQ-PKGQSREAFTLSLLSKFRTKLDNLKQKSSSDDGESEPKDIDDRVVEQEIIGDDW 442
            :||.|..|.| .||.|||..||:||::|::||       :....|:...||.:..||.:   :.|
Human   365 QKYEALRKQQSKKGTSREDQTLALLNQFKSKL-------TQAIAETPENDIPETEVEDD---EGW 419

  Fly   443 LSHTLNFNSTTPVLAKDANKKGDDWYDAYDPRNPLNKRKRGET 485
            :||.|.|...:..: |||:.:..|.::.||||||:|||:|.|:
Human   420 MSHVLQFEDKSRKV-KDASMQDSDTFEIYDPRNPVNKRRREES 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10907	NP_648508.1	cyclophilin_CeCYP16-like	8..178	CDD:238906	122/169 (72%)
		PTZ00121	<279..>426	CDD:173412	39/152 (26%)
		CWC27_CTD	390..451	CDD:412084	22/60 (37%)
CWC27	NP_005860.2	cyclophilin_CeCYP16-like	8..178	CDD:238906	122/169 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..386		62/203 (31%)
		DUF5401	<302..>472	CDD:375164	60/193 (31%)
		CWC27_CTD	376..428	CDD:412084	22/61 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..472		25/68 (37%)